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  • 1
    Electronic Resource
    Electronic Resource
    Mycophenolic acid trough levels after kidney transplantation in a cyclosporine-free protocol (2000)
    Springer
    Transplant international 13 (2000), S. S333 
    Details
    ISSN: 1432-2277
    Keywords: Key words Mycophenolate mofetil ; Mycophenolic acid ; Therapeutic drug monitoring ; Kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-seven stable kidney transplant recipients treated with cyclosporine and prednisone were converted to mycophenolate mofetil (MMF) and prednisone 1 year after transplantation. After conversion the patients were treated with a standard daily dose of 1 g MMF b. i. d. and 10 mg prednisone for 4 months. Thereafter, two MMF dose reductions were performed with a 4-month interval. Mycophenolic acid (MPA) trough levels were measured at regular intervals. A relation was found between MPA trough levels and MMF dose. The median MPA trough level for patients treated with 1 g MMF b. i. d. was 4.3 μg/ml (0.95–15.5) and 3.0 μg/ml (0.73–7.8) for patients treated with 750 mg b. i. d. (P = 0.0002). The MPA trough levels further decreased from 3.0 to 2.3 μg/ml (0.6–6.63) in patients treated with 500 mg MMF b. i. d. (P = 0.01). Dose reduction of MMF from 1 g to 750 mg b. i. d. could be performed without acute rejections. A further dose reduction to 500 mg b. i. d. elicited 3 rejections. Patients experiencing an acute rejection had a median MPA trough level of 2.3 μg/ml (1.26–3.38) compared to 3.8 μg/ml (1.48–6.52) in patients without an acute rejection (P = 0.25). We conclude that there is a significant relation between MPA trough levels and MMF dose. MPA trough levels were not predictive of rejection in the present study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050355
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Donor-specific CTL frequencies in peripheral blood in relation to graft vascular disease after clinical heart transplantation (1998)
    Springer
    Transplant international 11 (1998), S. S364 
    Details
    ISSN: 1432-2277
    Keywords: Key words Peripheral blood ; Chronic rejection ; CTL frequencies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cellular mechanisms may play a role in the development of graft vascular disease (GVD). We previously demonstrated that GVD correlated with an increase of donor-specific T-helper 1 cytokine production by graft-infiltrating lymphocytes but not by peripheral blood mononuclear cells (PBMC). These T-helper 1 cytokines aid the generation of cytotoxic T-lymphocytes (CTL). In the present report, we investigated whether there is a relationship between the frequency of donor-specific CTL precursors (pCTL) in PBMC and the development of GVD. We tested PBMC samples of five patients with GVD and five patients without GVD in the periods 3–6 months, 1 year, and 3 years after heart transplantation. At all time points, GVD was not related to the number of pCTL. In conclusion, donor-specific cellular tests in peripheral blood could not be related to GVD. Apparently, donor-specific reactions associated with the induction of GVD can only be monitored in the graft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050499
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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