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  • Articles: DFG German National Licenses  (41)
  • Electronic Resource  (41)
  • 1
    Electronic Resource
    Electronic Resource
    Cytokine profiles in spontaneously regressing basal cell carcinomas (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Basal cell carcinomas (BCCs) can cause considerable morbidity due to their ability to enlarge progressively and to destroy underlying tissues. However, some BCCs may undergo spontaneous regression in the absence of therapy capable of inducing antineoplastic effects. Histological criteria for this process have been described, and previous studies have suggested that it may be mediated by infiltrating activated CD4-positive T cells. Objectives The purpose of this study was to compare the expression of cytokines in actively regressing and non-regressing BCCs, to ascertain if active regression is associated with a particular cytokine profile. Methods Reverse transcriptase–polymerase chain reaction, a sensitive, quantitative technique allowing analysis of multiple cytokines from small tumour samples, was used. Results Interferon (IFN)-γ was significantly elevated in actively regressing BCCs compared with non-regressing BCCs. Furthermore, interleukin (IL)-2, tumour necrosis factor (TNF)-β and CD3δ tended to be elevated in actively regressing tumours, although not to statistically significant levels. IFN-γ, IL-2, IL-10, TNF-β, granulocyte-macrophage colony-stimulating factor and Fas ligand showed strong positive correlations with CD3δ, indicating an association between infiltrating T cells and these cytokines. Conclusions These findings support a role for T-helper 1 type cytokines in mediating spontaneous regression of BCCs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03596.x
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  • 2
    Electronic Resource
    Electronic Resource
    A Field Inoculation Method for Septoria tritici and Septoria nodorum (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 19 (1970), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A method is described, using a Czapek Dox V-8 agar and continuous irradiation with near-ultraviolet light, which enables large numbers of spores of Septoria tritici and Septoria nodorum to be produced rapidly and also allows easy identification of the two pathogens by their colony morphology. Also, a simple field inoculation method is described which has proved successful both in experiments involving different inoculum concentrations and for the screening of spring and winter wheat cultivars for their reactions against both pathogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1970.tb00983.x
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on dispersal of Septoria tritici pycnidiospores in wheat–clover intercrops (1998)
    Oxford, U.K. and Cambridge, USA : Blackwell Publishers
    Plant pathology 47 (1998), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Four experiments studied the effects of a clover understorey on pycnidiospore dispersal of Septoria tritici in a wheat–clover intercrop under simulated rain. Clover significantly reduced the dispersal of spores in a horizontal direction by 33% at a distance of 15 cm from a line inoculum source compared with a wheat monocrop. The clover also reduced the vertical movement of spores from infected leaves at the base of wheat plants by an average of 63% compared to the monocrop, and this suggests that the main movement of spores was from the base upwards. Splash experiments using blue colour marker showed the vertical decline of splash and the number of drops per cm2 with height caught on paper adjacent to trays of clover was described by the exponential decline model. The effect of clover in reducing vertical splash approached an asymptote as the leaf area index of the understorey increased. Simulated rain-splash increased the level of disease on the flag leaf and, in one experiment, there was a significant interaction between rain-splash and clover in reducing the number of lesions on the flag leaf. The level of disease resulting from one splash event was low, indicating that subsequent pathogen multiplication is probably required to bring about high severities of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3059.1998.00200.x
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  • 4
    Electronic Resource
    Electronic Resource
    NEW OR UNUSUAL RECORDS: A seedling blight of barley caused by Septoria nodorum (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 32 (1983), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1983.tb01322.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of temperature on head blight of wheat caused by Fusarium culmorum and F. graminearum (2005)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 54 (2005), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The effect of small temperature differentials (16 vs. 20°C) on the pathogenicity of deoxynivalenol producing single isolates of Fusarium culmorum and F. graminearum and on the fusarium head blight (FHB) response of eight wheat cultivars was examined. Fusarium culmorum inoculation caused greater visual disease symptoms at 20°C than at 16°C, both overall and on an individual cultivar basis (overall AUDPC = 13·5 and 9·6, respectively) (P 〈 0·05). In contrast, F. graminearum inoculation caused greater overall visual disease symptoms at 16°C than at 20°C, both overall and at the individual cultivar level (overall AUDPC = 12·8 and 10·9, respectively) (P 〈 0·05). Results showed both F. culmorum and F. graminearum inoculations caused a greater loss in yield at 20°C (54·3 and 46·9% relative 1000-grain weight, respectively) compared with 16°C (73·3 and 66·9% relative 1000-grain weight, respectively) (P 〈 0·05). Fusarium culmorum-inoculated heads contained similar amounts of fungal DNA at both 16 and 20°C (1·9 and 1·7 ng mg−1 of plant material, respectively) (not significant), while for F. graminearum inoculation, plants contained higher amounts of fungal DNA at 20°C (2·0 and 1·0 ng mg−1 of plant material, respectively) (P 〈 0·05). Overall, there was a significant negative correlation between AUDPC and percentage relative 1000-grain weight at both 16 and 20°C (r =−0·693 and −0·794, respectively, P 〈 0·01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.2005.01157.x
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  • 6
    Electronic Resource
    Electronic Resource
    ORAL EPITHELIAL NAEVI. (1959)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 71 (1959), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1959.tb13398.x
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  • 7
    Electronic Resource
    Electronic Resource
    LEUCOPLAKIA BUCCALIS AND ORAL EPITHELIAL NAEVI. A CLINICAL AND HISTOLOGIOAL STUDY. (1956)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 68 (1956), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1956.tb12803.x
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  • 8
    Electronic Resource
    Electronic Resource
    Revisiting Putative Functional Properties of the Plasmodium falciparum Pf155/RESA Protein Using Genetically Engineered Parasites (2005)
    Oxford, UK : Blackwell Science Inc
    The @journal of eukaryotic microbiology 52 (2005), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Pf155/RESA (Ring Infected Erythrocyte Surface Antigen), is a Plasmodium falciparum protein discharged by the dense granules of merozoites during invasion and exported to the inner face of the erythrocyte membrane, where it interacts with spectrin in the young stages. Chromosome 1 subtelomeric deletion, eliminating amongst others the resa gene, may occur during adaptation of parasite isolates to in vitro culture. This is accompanied by erythrocyte membrane modifications of the red blood cell, such as increased adhesion and effect on membrane rigidity. It has been proposed that RESA was likely to contribute to these functional and rheological modifications. To assess this, we have constructed resa knock-out parasites in the FUP/CB strain. This results in negativating the erythrocyte membrane immunofluorescence of glutaraldehyde-fixed red blood cells (EMIF), indicating that RESA is critical for EMIF reactivity of hyperimmune human sera. Phenotypic and functional analysis of resa k.o. parasites indicated that loss of RESA expression neither affects membrane rigidity nor CD36 binding under flow conditions. Furthermore, infection of Saimiri sciureus monkeys showed that resa gene deletion does not account on its own for the greater adaptation and parasite virulence in this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.2005.05202003_3_9.x
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  • 9
    Electronic Resource
    Electronic Resource
    Inflammation is associated with progression of actinic keratoses to squamous cell carcinomas in humans (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Squamous cell carcinoma (SCC) is a common skin tumour that may metastasize and lead to death. We have observed that before actinic keratoses (AK) progress to SCCs they may become tender and inflamed. In some of these, histological examination shows that they are, in fact, SCCs. Objectives To study the progression of AK to SCCs. Methods We studied skin tumours from 50 patients with either asymptomatic AK, inflamed AK or SCCs, using immunocytochemistry. The diagnosis of each tumour was confirmed by histological examination. Results Studies of differentiation using heat shock protein 27 showed a stepwise loss of differentiation as the tumours progressed from asymptomatic AK, through inflamed AK to SCCs. During the inflamed AK phase, there was a marked increase in T lymphocytes and Langerhans cells: the number of infiltrating cells diminished as progression to SCC occurred. There was an increase in immunoreactive p53 and the apoptosis inhibitor bcl-2 as tumours progressed from AK to SCCs, and a decrease in Fas and Fas ligand. Conclusions These studies have shown that progression from benign to malignant tumours may be associated with an inflammatory response, which appears to drive malignant conversion, but subsides rapidly following this conversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04720.x
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  • 10
    Electronic Resource
    Electronic Resource
    An absorption feature in the spectrum of the pulsed hard X-ray flux from 4U0115 + 63 (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 240-243 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A spectral feature, apparently an absorption line, has been observed at an energy of 20.1 ± 0.5 ke V in the pulsed flux of 3.61 s X-ray pulsar 4U0115 + 63 using the UCSD/MIT instrument on HEAO 1. The line strength, expressed as equivalent width, is 3.1 ± 0.5 ke V. Although ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282240a0
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