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Digitale Medien

The partial dopamine receptor agonists (−)-3-PPP and transdihydrolisuride enhance prolactin secretion in female but not in male rats (1989)

Carlsson, M. ; Eriksson, E.

Springer

Journal of neural transmission 77 (1989), S. 211-216

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Details

ISSN: 1435-1463

Schlagwort(e): (−)-3-PPP ; TDHL ; prolactin ; sex difference ; rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The effects exerted by the partial dopamine (DA) receptor agonists (−)-3-(3-hydroxyphenyl)-N-n-propylpiperidine [(−)-3-PPP] and transdihydrolisuride (TDHL) on prolactin secretion were compared in male and female rats. Both agents were found to increase prolactin release more than tenfold in female rats. In male rats, in contrast, (−)-3-PPP and TDHL were either without effect or decreased prolactin secretion. It is suggested that this sexually differentiated prolactin response to partial DA agonists reflects a lower responsiveness of lactotroph DA receptors in female than in male rats.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01248933

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