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  • Electronic Resource  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of PCB administration on microsomal enzyme activity in pregnant rabbits (1971)
    Springer
    Bulletin of environmental contamination and toxicology 6 (1971), S. 120-128 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540092
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  • 2
    Electronic Resource
    Electronic Resource
    A new model of human secretory diarrhoea using cholera toxin (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 6 (1992), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Secretory diarrhoea is a major cause of morbidity and mortality worldwide. However, there is no biologically relevant test system in man for assessing new anti-diarrhoeal therapies prior to clinical trial. We have used highly purified cholera toxin in combination with the triple lumen jejunal perfusion technique to establish a subclinical model of cholera in man. Cholera toxin was administered either by mouth with sodium bicarbonate or directly into a 30 cm‘open’ or‘closed’(isolated between two inflated balloons) jejunal segment in healthy adult volunteers. Both oral dosing and direct delivery into an‘open’ jejunal segment failed to produce consistent secretion of water and electrolytes. In contrast 15 μg or 25 μg of cholera toxin elicited secretion of water and sodium 3 h after instillation into the balloon occluded‘closed’ jejunal segment (P 〈 0.05 vs. controls). The rate of secretion was constant over the maximal period studied (4.5 h) and was similar to that reported in human cholera. None of the subjects experienced troublesome diarrhoea. We believe this model offers a relevant test system for assessing anti-diarrhoeal therapy in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1992.tb00576.x
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  • 3
    Electronic Resource
    Electronic Resource
    Some Pharmacological Properties of a New Adrenergic β-Receptor Antagonist (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 88-90 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Increases in heart rate were produced in anaesthetized cats by the constant intravenous infusion for 10 min of isoprenaline at 0-2 [xg/kg/min before and after the intravenous infusion for 30 min of 'I. C. I. 45,763' at 1, 5 or 25 [jLg/kg/min. (All drugs were in the racemic form and are here ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212088a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Trifluoromethyl-benzimidazoles—a New Family of Acaricides (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 275-276 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Pure NC 5016 is a colourless crystalline solid, melting at 103 C, with a vapour pressure of 4xlO5 mm of mercury and a solubility in water at 25 C of 13 p.p.m. Its solubilities in organic solvents are: benzene, more than 40 per cent; dioxane, more than 50 per cent; acetone, more than 50 per cent; ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215275a0
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats (1989)
    Springer
    Psychopharmacology 97 (1989), S. 54-58 
    Details
    ISSN: 1432-2072
    Keywords: Feeding ; 5-HT antagonists ; 5-HT1 receptors ; 5-HT1C receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of nine central 5-HT antagonists on food intake in free feeding male rats were examined. The 5-HT2 antagonists ritanserin and ketanserin and the selective 5-HT3 antagonists ICS 205-930 and MDL 72222 had no effect on food intake. In contrast, the non-selective 5-HT antagonists metergoline, methiothepin, mesulergine, mianserin and methysergide (all of which have high affinity for various 5-HT1 receptor subtypes), dose-dependently increased food intake during a 4-h daytime test. Furthermore, metergoline dose dependently increased food intake over a 24-h period. Suprisingly, mesulergine decreased food intake over a 24-h period at the same doses that increased daytime food intake. This may indicate that the increase in daytime feeding produced by mesulergine is a non-specific response. Although the antagonists used have varying degrees of selectivity for 5-HT receptor subtypes, the pattern of results suggests that postsynaptic 5-HT1 receptors (possibly of the 5-HT1C type) play an important role in the control of feeding in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443413
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  • 6
    Electronic Resource
    Electronic Resource
    The role of reciprocity and proximity in junior high school friendships (1988)
    Springer
    Journal of youth and adolescence 17 (1988), S. 403-411 
    Details
    ISSN: 1573-6601
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract The relationship of reciprocity, sex, and race to friendship proximity in adolescent friendships was studied. Intelligence, personality, physical attractiveness, popularity, and proximity were measured for 136 junior high school students. Subjects were classified as either having reciprocated or nonreciprocated friendships. Reciprocated adolescents were perceived as more attractive, had higher social status, and were more committed to their best friend than nonreciprocated adolescents. More black than white students were in the nonreciprocated group. White students had more in-school contact and black students more out-of-school contact with their friends.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537882
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  • 7
    Electronic Resource
    Electronic Resource
    Duodenal perforation without abdominal pain during peroral biopsy with the Baker-Hughes tube (1968)
    Springer
    Digestive diseases and sciences 13 (1968), S. 584-587 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233075
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  • 8
    Electronic Resource
    Electronic Resource
    Correlates of loneliness in midadolescence (1992)
    Springer
    Journal of youth and adolescence 21 (1992), S. 151-167 
    Details
    ISSN: 1573-6601
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract The present study was designed to assess the relationship between adolescent loneliness and the following factors commonly associated with adult loneliness: attributional style, self-esteem, social anxiety, and social skills. Subjects were 186 ninth-grade students (107 males and 79 females) who were asked to complete seven different paper-and-pencil measures. Data were analyzed by calculating separate stepwise multiple regression equations for the total sample, males and females. Three significant predictors were found for the total sample: student social skills rating scale, self-esteem, and the perception of stability in interpersonal situations (attributional style). A different pattern of predictors emerged for males and females. Loneliness could be predicted for males from three variables: low self-esteem, the perception of uncontrollability in noninterpersonal situations, and self-perceptions of poor social skills. The best multiple predictors of loneliness for the females were self-perceptions of poor social skills, high social anxiety, and stable attributions for interpersonal situations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537334
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  • 9
    Electronic Resource
    Electronic Resource
    Chlorpromazine metabolism. IX. Pharmacokinetics of chlorpromazine following oral administration in man (1978)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 6 (1978), S. 187-196 
    Details
    ISSN: 1573-8744
    Keywords: Chlorpromazine ; pharmacokinetics ; oral absorption ; single dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A single oral dose (120 mg/m2) of Chlorpromazine hydrochloride was administered to four healthy subjects and the blood levels of Chlorpromazine were determined with time. Appropriate equations describing the two-compartment open model with zero-order absorption and the two-compartment model with first-order absorption, both with a lag time, were fitted to the observed data using weighted nonlinear least-squares regression analysis. Fitting the two-compartment model with zero-order absorption and a lag time to the observed data resulted in a significant reduction of the weighted sum of squared deviations, i.e., better correlation between the observed and calculated data, and a closer random scatter of the observed concentration data around the calculated curve with no apparent systematic deviations from the curve. These results suggest that Chlorpromazine absorption is zero order. Chlorpromazine began to appear in the systemic circulation after a mean lag time of 0.4 hr and continued to be absorbed for approximately 2.9 hr. The mean half-lives of the distribution and elimination phases were 1.63 and 17.7 hr, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01312261
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