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  • Electronic Resource  (20)
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  • Electronic Resource  (20)
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  • 1
    Electronic Resource
    Electronic Resource
    Histones and the Control of Gene Action (1969)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 3 (1969), S. 155-180 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ge.03.120169.001103
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of Inhibitory Action of Histones on DNA Template Activity in vitro (1970)
    [s.l.] : Nature Publishing Group
    Nature 228 (1970), S. 245-247 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] If RNA is synthesized on the chromatin deoxyribonucleoprotein (DNP) template, the chains formed are four to five times shorter than in RNA synthesized on a DNA template. This correlates with the decrease of the period of elongation. After the removal of histone F1 from DNP the RNA chains ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/228245a0
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear Ribonucleoprotein Particles Containing Messenger Ribonucleic Acid (1966)
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 1319-1322 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has been shown that the chromosomes of animal cells contain significant quantities of D-RNA-RNA with DNA-like base composition1'2. Chromosomal D-RNA is actively hybridized with homologous DNA, and stimulates the incorporation of amino-acids in a cell-free system4 and the biosynthesis of specific ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2101319a0
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  • 4
    Electronic Resource
    Electronic Resource
    Very long stretches of free DNA in chromatin (1974)
    [s.l.] : Nature Publishing Group
    Nature 250 (1974), S. 602-606 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Long stretches of completely free DNA in DNP?F1. Mice carrying Ehrlich ascites tumour cells were injected intraperitoneally with a mixture of methyl-3H-thymidine and L-14C-lysine to obtain a double-labelled chromatin10?12. Less than 0.1 % of the total 14C counts were in DNA and 0.1?0.2 % of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/250602a0
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  • 5
    Electronic Resource
    Electronic Resource
    Biosynthesis of Messenger and Ribosomal Ribonucleic Acids in the Nucleolochromosomal Apparatus of Animal Cells (1963)
    [s.l.] : Nature Publishing Group
    Nature 200 (1963), S. 1291-1294 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DURING recent years we have been investigating the problem of biosynthesis of RNA in the nucleus of mammalian cells. The main method used was phenol fractionation of cellular RNA which permits the separation of the rapidly labelled RNA of the cell and isolation of its fractions. This article ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2001291a0
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  • 6
    Electronic Resource
    Electronic Resource
    Reiterated genes with varying location in intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes (1978)
    Springer
    Chromosoma 70 (1978), S. 1-17 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The localization of two cloned D. melanogaster DNA fragments in polytene chromosomes was determined by means of in situ hybridization. These different fragments (Dm 225 and Dm 234B) are present in the genome in hundreds copies and contain genes whose transcription yields two different classes in abundant mRNA (Ilyin et al., 1976, 1977; Tchurikov et al., 1978). About 20–30 sites of these genes are demonstrable in the polytene chromosomes of a given stock. There are small but significant variations in the number and localization of these sites among individuals of the same stock. On the other hand, different stocks of D. melanogaster have an utterly different distribution of revealed hybridization sites in the polytene chromosomes. The location of both fragments (Dm 225 and Dm 234) was found to be virtually identical within any given stock of D. melanogaster. 69 sites for localization of Dm 225 or Dm 234 genes were detected in the chromosomes of 11 individuals studied. At least 50 (and up to 62) of them coincide with intercalary heterochromatin regions which are known to be characterized by ectopic pairing, late replication and the presence of “weak spots” in the chromosome. The ability of Dm 225 and Dm 234 to code for the “abundant” classes of messenger RNA (Ilyin et al., 1976) and the fact that their location may coincide with the histone and ribosomal genes suggest that intercalary heterochromatin regions are “nests” containing various types of actively transcribable tandem-repeated genes coding for common “household” cell functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292211
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  • 7
    Electronic Resource
    Electronic Resource
    Studies on structure and function of chromatin (1981)
    Springer
    Molecular and cellular biochemistry 40 (1981), S. 29-48 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary This article covers research work in this laboratory on the structure and function of chromatin. Early studies have led to discovery of skeletal fibrills (nucleonemas) within the nuclei and showed the specific role of histone H1 in chromatin condensation and in restriction of transcription. More recently with the aid of a novel DNP electrophoresis technique the relation of histone HI and non-histone proteins to nucleosomes was studied. Three types of mononucleosomes and a number of subnucleosomes were identified in chromatin digests. The complexes of certain HMG proteins with short DNA segments were isolated and found to originate from transcriptionally active chromatin. Different forms of SV40 minichromosome were characterized. A method for the analysis of nucleosome distribution along the DNA sequence was elaborated and used to show non-random (phased) location of nucleosomes on SV40 DNA. The attachment of DNA to skeletal elements of interphase nuclei and metaphase chromosomes was shown to be a non-random, probably sequence-specific process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230186
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  • 8
    Electronic Resource
    Electronic Resource
    Arrangement of histones along DNA in chromosomal deoxyribonucleoprotein lacking histone F1 (1973)
    Springer
    Molecular biology reports 1 (1973), S. 87-92 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In deoxyribonucleoprotein from which histone F1 and most nonhistone proteins were removed by treatment with tRNA in the presence of Mg2+, one can find very long stretches of completely free DNA (average length of about 4×103 base pairs). They alternate with stretches of DNA (∼16×103 base pairs) which are nearly uniformly covered with the other four histones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00357586
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  • 9
    Electronic Resource
    Electronic Resource
    Hybridization of mRNA and pre-mRNA with the sequences forming double-stranded structures in pre-mRNA (1973)
    Springer
    Molecular biology reports 1 (1973), S. 215-219 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract About 25% of the double-stranded sequences isolated from pre-mRNA are able to hybridize, after melting, with either mRNA or non-melted pre-mRNA. The retention of one branch of pre-mRNA hairpin in mRNA was suggested. It was also found that in addition to the hairpin-like structures comprising about 3% of the total sequences another 15% of the pre-mRNA sequences can form double-stranded structures upon annealing over a broad interval of Cot values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00357644
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  • 10
    Electronic Resource
    Electronic Resource
    Direct demonstration of a complementarity between mRNA and double-stranded sequences of pre-mRNA (1976)
    Springer
    Molecular biology reports 2 (1976), S. 353-361 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The total poly(A)-containing mRNA from mouse liver or Ehrlich ascites carcinoma cells was annealed with denatured ds RNA prepared from heavy nuclear 3H-labeled pre-mRNA of the same tissue. The hybrids formed were detected by binding of complexes to poly(U)-Sepharose columns through the poly(A) of mRNA. With this technique, about 30% of labeled ds RNA was bound to poly(U)-Sepharose after annealing it with an mRNA excess. The proportion of hybrid material detected by RNase treatment was two to three times lower than that obtained by poly(U)-Sepharose binding. The length of the RNase-stable acid precipitable hybrid material consisted of heterogeneous sequences of 10–100 nucleotides long when cytoplasmic, and 10–60 nucleotides long when polysomal mRNA was used in the hybridization reaction. The results obtained show that at least some of the mRNA molecules contain sequences complementary to one of the branches of the pre-mRNA hairpins. These results are compatible with the idea that the hairpin-like sequences in pre-mRNA are localized between mRNA and the non-informative part of the precursor molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366256
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