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  • 1
    Electronic Resource
    Electronic Resource
    Ar+3 photodissociation and its mechanisms (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 4019-4025 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photodissociation spectrum of Ar+3 between 520 and 620 nm is reported. A broadband peaking near 520 nm is observed with a cross section of ∼1.8×10−16 cm2 at the peak, in agreement with the findings of Levinger et al. [J. Chem. Phys. 89, 71 (1988)]. However, in the present work, a shoulder whose prominence is highly temperature dependent is observed between 545 and 555 nm. The new results are discussed in terms of various electronic transitions and pathways to dissociation. The photodissociation mechanisms are studied by translational energy analysis of photofragmentation. Three photodissociation mechanisms that involve two electronic energy surfaces are proposed which account for the experimental findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456832
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  • 2
    Electronic Resource
    Electronic Resource
    The C-Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The metabotropic glutamate receptor (mGluR) subtype 1 exists as at least three variants (−1a, −1b, and −1c) generated by alternative splicing at the C-terminal domain. Fluorometric Ca2+ measurements were used to compare the concentration dependency of agonist-induced rises in intracellular free Ca2+ concentration ([Ca2+]i) in human embryonic HEK 293 cells transiently expressing rat mGluR1a, mGluR1b, or mGluR1c. The rank order of agonist potencies was quisqualate ≫ (2S,1′S,2′S)-2-(carboxycyclopropyl)glycine (L-CCG-I) 〉 (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] and did not differ among the splice variants. However, agonists were consistently more potent at mGluR1a than at mGluR1c and mGluR1b. In the same system, we characterized the agonist pharmacology of two chimeric rat mGluR3/1 receptors where the first and/or the second intracellular loop(s) and the C-terminal domain were exchanged with the corresponding mGluR1a or mGluR1c sequences and that were previously shown to mediate elevations in [Ca2+]i in response to agonists. The potency of agonists was higher at the chimera having the C-terminus of mGluR1a as compared with those having the mGluR1c C-terminus. Both chimeric mGluR3/1 receptors had the same rank order of agonist potencies: L-CCG-I ≫ (1S,3R)-ACPD ∼ quisqualate. These data support the hypothesis that the C-terminal domain of mGluRs plays a role in determining the potency of agonists for inducing mGluR-mediated functional responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67010058.x
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  • 3
    Electronic Resource
    Electronic Resource
    A DOUBLE BLIND TRIAL OF EXTRA-AMNIOTIC OESTRIOL AND PROSTAGLANDIN F2α GELS IN CERVICAL RIPENING (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty nulliparous patients with a Bishop score of 3 or less were given 15 mg oestriol gel, 10 mg PGF2α gel or gel alone via the extra-amniotic route. Both the oestriol and prostaglandin treated patients had a significant increase in Bishop score and a significant reduction in induction-delivery interval compared to con-trols. Oestriol gel had significantly less stimulatory effect on uterine activity than prostaglandin gel, indicating a possible local action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb01223.x
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  • 4
    Electronic Resource
    Electronic Resource
    Galvanic Corrosion on Cast Iron Pipes (1930)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 22 (1930), S. 335-341 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50244a008
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  • 5
    Electronic Resource
    Electronic Resource
    Iroquoian Archaeology (1992)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 21 (1992), S. 435-460 
    Details
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.an.21.100192.002251
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  • 6
    Electronic Resource
    Electronic Resource
    Plant Pigments (1935)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 4 (1935), S. 479-496 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.04.070135.002403
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  • 7
    Electronic Resource
    Electronic Resource
    Photodissociation of rare gas cluster ions: Ar+3 (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 5043-5044 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photodissociation spectrum of the mass selected cluster ion Ar+3, produced by electron impact ionization of a supersonic cluster beam, has been measured for the first time. Measurements over the wavelength range 539 to 620 nm show the cross section to rise and peak near 545 nm and then decrease steadily throughout the longer wavelength range; the magnitude of the cross section is found to be smaller than the corresponding 2Σ+u→2Σ+g transition of Ar+2 in agreement with some theoretical predictions. Interestingly, Ar+ is the only detected photoproduct.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453709
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  • 8
    Electronic Resource
    Electronic Resource
    The role of rotational tunneling in the metastable decay of rare gas cluster ions (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 6335-6340 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The decay of (Ar+3)*→Ar+2+Ar is found to be metastable on a time scale longer than 40 μs. Theoretical considerations are presented for these slow metastable dissociation rates reported in this and other studies. From model calculations it is inferred that tunneling lifetimes from 10−10 to 10 s may be observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.454471
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  • 9
    Electronic Resource
    Electronic Resource
    Enrichment and Characterization of Dendritic Cells from Rat Renal Mesangium (1997)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 46 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dendritic cells (DC) initiate primary immune reactions and are distributed throughout most tissues. The most potent DC population of the kidney has long been suggested to reside within the glomerular mesangium. Using LEW.1A rats, we enriched and characterized such low-density cells. Mesangial DC generally exhibited round to oval cell bodies and cytoplasmic veils. Phenotypically, these cells were 100% OX-6++, 45% OX-42++, 35% ED1low, 10% OX-62low, and negative for ED2 and α-naphtylbutyrate esterase. Introducing a new monoclonal antibody, R3, which stains a subset of splenic DC, we showed strong antigen expression on 60% of mesangial DC. Correlating cell populations were detected immunohistochemically. Functionally, mesangial DC potently stimulated allogeneic mixed leucocyte reactions, but did not phagocytose opsonized Escherichia coli. In addition to their striking phenotypic similarity with autologous splenic DC, mesangial DC exhibited 88% of the allostimulatory activity of splenic DC. Calculation indicated approximately two mesangial DC per glomerulum. We suggest that these cells comprise different maturation-dependent subsets. The OX-62 integrin especially appears to be expressed only on mature mesangial DC, which may correlate to lymphoid veiled cells or interdigitating DC. An employment of mesangial DC in experimental models of acute allograft rejection or glomerulonephritis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-175.x
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  • 10
    Electronic Resource
    Electronic Resource
    The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons (1998)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 10 (1998), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cultured cerebellar granule cells grown in medium containing 10 mm K+ undergo apoptosis after 4–5 days in vitro (DIV), and, at that time, the activity of metabotropic glutamate (mGlu) receptors coupled to polyphosphoinositide (PI) hydrolysis begins to decline. In granule cells at 4 DIV, the mGlu receptor subtype mGlu5 was expressed at high levels. The expression of another PI-coupled mGlu receptor, the mGlu1a, was low at 4 DIV but increased during the following days. In cultures at 4–5 DIV, the few cells that already showed an apoptotic phenotype were devoid of mGlu5 receptors, but they all expressed mGlu1a receptors. The development of apoptosis was accelerated after treating the cultures with: (i) mGlu5 antisense oligonucleotides; (ii) the mixed mGlu receptor antagonist, (+)-α-methyl-4-carboxyphenylglycine; or (iii) the glutamate depleting enzyme, alanine aminotransferase. In contrast, an induced overexpression of mGlu5 receptors protected cultured granule cells against apoptotic death. We suggest that the activity of mGlu5 receptors supports cell survival, and a decline in the expression of mGlu5 receptors gives access to programmed cell death in cerebellar granule cells developing in primary cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1998.00230.x
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