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  • 1
    Electronic Resource
    Electronic Resource
    Effect of clonidine on sleep patterns in man (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 319-322 
    Details
    ISSN: 1432-1041
    Keywords: Clonidine ; Yohimbine ; sleep ; REM sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clonidine (300 µg orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an α sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562444
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    CYCLIC 3′5′-ADENOSINE MONOPHOSPHATE AND CENTRAL CIRCULATORY CONTROL IN CATS AND DOGS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Dibutyryl cyclic AMP (Db CAMP, 75–500 μg/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate.2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure.3. A number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new β2-adrenoceptor stimulant, NAB 365.4. Injection into the lateral ventricle of theophylline or Ro 7/ 2956, both inhibitors of phosphodiesterase, similarly increased blood pressure.5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H1- or H2-receptors.6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective.7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02671.x
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  • 3
    Electronic Resource
    Electronic Resource
    Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 255-261 
    Details
    ISSN: 1432-1912
    Keywords: Baroreceptor reflex arc ; Carotid sinus nerve ; Centrally mediated vagal bradycardia ; Fentanyl ; Nucleus of the solitary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In dogs, anaesthetized with chloralose, fentanyl (5 μg/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not change the bradycardic response to stimulation of the nucleus of the solitary tract (NTS) indicating that a central facilitation of baroreceptor impulses occurs within the NTS, probably at the first synapse of baroreceptor reflex fibres. Bilateral destruction of the NTS caused a ful-minating hypertension and tachycardia similar to that after cutting the baroreceptor afferent fibres. After both procedures, fentanyl (20 μg/kg i.v.) produced marked hypotension and bradycardia. The bradycardic effect was abolished by cutting both vagal nerves when the dogs were pretreated with a β-adrenoceptor blocking agent (S 2395, 50 μg/kg i.v.). The results provide evidence that the NTS is not the main site of action either for the hypotensive effect or for the vagally mediated bradycardia of fentanyl. Since the dorsal nucleus of the vagal nerve was destroyed together with the NTS, this nucleus does also not appear to be a major site of the action of fentanyl. Blockade of dopamine receptors by haloperidol or pimozide or of serotonin receptors by methysergide did not change the hypotensive, bradycardic and sympathoinhibitory effects of fentanyl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498691
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Splitting of target fibers: Myopathic signs in denervation phenomena (1977)
    Springer
    Journal of neurology 214 (1977), S. 159-162 
    Details
    ISSN: 1432-1459
    Keywords: Voluntary muscle ; Denervation atrophy ; Myopathy ; Target fibers ; Fiber splitting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Faserspaltungsphänomene an Targetfasern in einem Fall von neurogener Muskelatrophie der Beine mit ausgeprägter Begleitmyopathie werden beschrieben und diskutiert. Erstmals wird das typisch myopathische Phänomen der Faserspaltung an für die neurogene Muskelatrophie als typisch erachteten Targetfasern dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02430353
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple Frakturen des Atlas mit zweizeitiger tödlicher Vertebralisthrombose nach Schleudertrauma der Halswirbelsäule (1977)
    Springer
    Archives of orthopaedic and trauma surgery 87 (1977), S. 235-244 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen 62 Jahre alt gewordenen Mann berichtet, der auf dem Heimweg von der Arbeit in seinem PKW bei etwa 70 km/h einen Frontalzusammenstoß mit anschließendem Überschlagen erlitt. Da der Betroffene angeschnallt war und das Fahrzeug nach dem Überschlag wieder auf den Rädern zu stehen kam, war es nicht zu einem Anschlag des Kopfes gekommen, wie das Fehlen von Kopfverletzungen zeigte. Nach kurzer Bewußtlosigkeit bot der Patient keine neurologische Symptomatik; es bestanden lediglich Nackenschmerzen bei ausgeprägtem linksseitigem Nackenhämatom. Eine Berstungsfraktur des Atlasringes (Jefferson-Fraktur) mit Trümmerfraktur der linken Massa lateralis wurde in Standardröntgenaufnahmen nicht erkannt. Nach achttägigem „Wohlbefinden“ verstarb der Patient plötzlich und unerwartet. Bei der Sektion fand sich eine frische Thrombose der linken Arteria vertebralis, wobei mikroskopisch multiple dissezierende Wandverletzungen mit intramuralen Blutungen zu erkennen waren.
    Notes: Summary Report of the case of a 62 year old male, who died in a car crash on his way home from duty, when he had a frontal collison with annother car at a speed of about 70 km per hour. After the collision, the car had completely turned over to its wheels. As the man had put on the seat belts, he had not been cast against the front window so that there were no head injuries. Following an unconsciousness of about ten minutes the patient recovered quickly and was already fully oriented when arrived at hospital. No neurological symptoms could be substantiated. He only suffered from pain of the neck and had a marked swelling of the left side of the neck. A bursting fracture of the atlas vertebra (Jefferson-fracture) was overlooked in routine X-rays of the craniovertebral region. Eight days after the accident, the hitherto “well improving” patient died suddenly and unexpectedly. The autopsy revealed an obstructing thrombosis of the left vertebral artery, less than 24 hours old. The wall of the artery showed numerous dissecting ruptures with intramural bleedings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415211
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