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  • 1
    Digitale Medien
    Digitale Medien
    Near-infrared spectra of water and aqueous electrolyte solutions at high pressures (1984)
    Springer
    Journal of solution chemistry 13 (1984), S. 811-823 
    Details
    ISSN: 1572-8927
    Schlagwort(e): High pressure ; near-infrared spectra ; water ; aqueous electrolyte solutions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The near-infrared spectra (9500 to 11000 cm−1) of pure water and aqueous solutions of alkali halides, MgCl2, NaClO4, and R4NBr were measured at temperatures between 10 and 55°C and pressures up to 500 MPa. From the analysis of the absorption spectra the following conclusions are drawn. (1) The ice I-like open structure is destroyed and the packed structure is formed as the pressure is increased. (2) The open structure of water is destroyed by the addition of alkali halides and MgCl2 and water molecules are restricted around the ions by ion-dipole interactions. This results in a loosening of the O−H bond. (3) The perchlorate ion destroys the open structure of water and the ion-dipole interaction with water is insignificant. (4) The Bu4N+ ion forms water structure around the ion similar to that of the clathrate open structure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00647696
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  • 2
    Digitale Medien
    Digitale Medien
    Demyelination in the spinal cord of murine globoid cell leukodystrophy (the twitcher mouse) (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 298-308 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Globoid cell leukodystrophy ; Twitcher mouse ; Demyelination ; Spinal cord
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Chronologic events of demyelination were investigated in the spinal cord of the twicher mouse, an authentic murine model of human globoid cell leukodystrophy (GLD) from 5 to 45 days postnatal. There was very little evidence of myelin degeneration before day 25 although clustered or scattered globoid cells were already noted in the dorsal columns and intramedullary portion of the ventral roots. Globoid cells contained typical cytoplasmic inclusions and in those which were found adjacent to degenerating myelin and naked axons, myelin debris were conspicuous in their cytoplasm. Vesiculation of myelin and a feature of globoid cells stripping myelin lamellae were noted in the area of demyelination. Myelin and oligodendroglial degeneration became pronounced throughout the spinal white matter after day 40 but globoid cells tended to be more concentrated in the dorsal columns. Our observations suggest that the emergence of globoid cells in GLD is in response to the changes in biochemical environment (i.e., excessive presence of galactosylceramide in the tissue?), and these cells appear to have a role as phagocytic cells in removing myelin lamellae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687612
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  • 3
    Digitale Medien
    Digitale Medien
    Wide-range line-tunable oscillation of an optically pumped NH3 laser (1980)
    Springer
    Applied physics 21 (1980), S. 237-240 
    Details
    ISSN: 1432-0630
    Schlagwort(e): 42.55 ; 42.60 ; 34.50
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Selective single-line oscillation has been obtained from an NH3 laser in the range from 11 to 13 μm. Pumping of high pressure NH3−He mixture with theR(30) line of a TEA-CO2 laser made it possible to tune on more than 30 lines with the aid of a grating. However, such line tunable oscillation was not observed when theR(16) line was used for pumping. Reasons for this difference are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00886173
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  • 4
    Digitale Medien
    Digitale Medien
    Effects of protizinic acid on leukokinin generation and its physiological action (1984)
    Springer
    Inflammation research 14 (1984), S. 699-706 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of protizinic acid (PRT), a non-steroidal antiinflammatory drug, on thein vivo leukokinin (LK) generation system using feline acute ischemia model,in vitro LK generation system and the LK-induced contraction of the isolated smooth muscle was investigated. When 3 mg/kg PRT was injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity was inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of LK, was observed. Simultaneously, ST-segment elevation on the electrocardiogram tended to be suppressed and the lowered mean aortic blood pressure was significantly restored. On the LK generation induced by rabbit kininogen and acid protease derived from mouse L-1210 leukemic cells or rabbit polymorphonuclear leukocytes, PRT showed a dosedependent inhibition while indomethacin (IM) and ibuprofen (IB) at a concentration of 3×10−4 M showed no effect. However, potencies of the inhibitory actions of PRT, IM and IB on the LK generation induced by bovine spleen cathepsin D were almost the same at a concentration of 3×10−4 M. Furthermore, PRT as well as IM showed antagonistic action on the isolated rat uterine contraction induced by LK. These results suggest that PRT not only inhibits thein vitro andin vivo generation of LK but also antagonizes to it on the receptor site of LK.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01978911
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  • 5
    Digitale Medien
    Digitale Medien
    Anti-oxidative effect of coenzyme Q10 (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1002-1003 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Coenzyme Q10 is effective as an anti-oxidant like α-tocopherol, especially in the heart.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01953847
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  • 6
    Digitale Medien
    Digitale Medien
    Cerebro-ocular dysplasia —Muscular dystrophy (COD-MD) syndrome (1984)
    Springer
    Acta neuropathologica 65 (1984), S. 110-123 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Congenital muscular dystrophy ; Micropolygyria ; Pachygyria ; Retinal dysplasia ; Hydrocephalus ; Warburg syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The Fukuyama form of congenital muscular dystrophy (FCMD), first described in Japan, is associated with distinct dysplastic cerebral malformations including agyria and micropolygyria of cerebral cortex, micropolygyria of cerebellum, and leptomeningeal gliomesodermal proliferations. We describe seven cases in four families from the United States with a syndrome similar to FCMD but with additional ophthalmic malformations. We believe that these cases represent a form of congenital muscular dystrophy different from FCMD and termed it cerebroocular dysplasia-muscular dystrophy (COD-MD) syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690464
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  • 7
    Digitale Medien
    Digitale Medien
    Vascular changes of methotrexate-related disseminated necrotizing leukoencephalopathy (1984)
    Springer
    Acta neuropathologica 65 (1984), S. 145-149 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Disseminated necrotizing leukoencephalopathy (DNL) ; Methotrexate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We investigated cerebral lesions of methotrexate (MTX)-related disseminated necrotizing leukoencephalopathy (DNL) in two autopsy cases of leukemia by the reconstruction technique of the serial sections and thick sections (700–800 μm) stained with silver impregnation to detect the topographic relation between the vascular changes and parenchymal lesions. We revealed the vascular changes, such as fibrinoid degeneration, hyalinized thickening of the vascular wall, dilatation of lumen and stenosis due to swelling of the endothelial cells and exsudation in the wall, particularly prominent in venules and capillaries of venous side in the territory of the superficial medullary veins. There were no remarkable changes in the arteries, except for the moderate endothelial swelling of arteriolar capillaries. The parenchymal lesions were topographically associated with these vascular changes, and the small necrotic foci confluented each other and formed large irregular necrotic foci. We considered that the DNL may be ascribed to dyshoric damage of the veins and capillaries of the venous side and that the mechanism of vascular injury was probably due to the prolonged direct action of intrathecal MTX on the vessels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690468
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  • 8
    Digitale Medien
    Digitale Medien
    Ultrastructural localization of dipeptidyl peptidase IV in rat salivary glands by immunocytochemistry (1984)
    Springer
    Cell & tissue research 235 (1984), S. 427-432 
    Details
    ISSN: 1432-0878
    Schlagwort(e): DPP IV ; Salivary glands ; Ultrastructural localization ; Immunocytochemistry ; PAP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The ultrastructural localization of dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) in rat submandibular and parotid glands was studied immunocytochemically by the peroxidase-antiperoxidase (PAP) method, using a monospecific antiserum against rat kidney DPP IV. There were no differences in the immunocytochemical localization of DPP IV between submandibular and parotid glands. In these glands, DPP IV was primarily found to be associated with the luminal and intercellular canalicular plasma membranes of acinar cells and with the luminal plasma membranes of intercalated and striated duct cells. Occasionally, immunoreaction of DPP IV was detected in cytoplasmic vesicles (vacuoles), lysosomes, and multivesicular bodies in some acinar cells as well as in ductal epithelial cells. Furthermore, the reaction product was also found within the lumina of peri-acinar and peri-ductal capillaries and in the cytoplasm of some fibroblasts in the interstitial connective tissue. These data suggest that DPP IV in the submandibular and parotid glands may play some role in the secretion or reabsorption processes of secretory proteins and peptides in these glands.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00217869
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  • 9
    Digitale Medien
    Digitale Medien
    Moisture sensor device of plasma-films doped with methylbromide (1984)
    Springer
    Polymer bulletin 11 (1984), S. 541-544 
    Details
    ISSN: 1436-2449
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Summary Films plasma-polymerized from the tetramethylsilane/ammonia gas mixture were sensitive in electrical resistance to moisture. A linear relationship between the logarithm of the electrical resistance and the relative humidity was observed. This susceptibility in the electrical resistance to moisture was improved by doping of methylbromide. This improvements by the doping treatment may be as results of quaternization of amino groups and of hydrolysis of methylbromide. The improved device could detect relative humidity from 20 to 90 % where the electrical resistance varied from 107 to 104 Ω. The response time was less than twenty-five seconds, and the hysteresis in cyclic changing of the relative humidity was negligible.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01045334
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