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  • 1985-1989  (16)
  • 1989  (7)
  • 1986  (9)
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  • 1985-1989  (16)
Year
  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 2 (1986), S. 0 
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Soil samples have been taken periodically from unlimed plots of the 130-year-old Park Grass Experiment and from the 100-year-old Geescroft Wilderness at Rothamsted. Changes in the pH of the samples show how acidification has progressed. The soils are now at, or are approaching, equilibrium pH values which depend on the acidifying inputs and on the buffering capacities of the soils. We have calculated the contributions to soil acidification of natural sources of acidity in the soil, atmospheric deposition, crop growth and nutrient removal, and, where applicable, additions of fertilizers. The relative importance of each source of acidification has changed as the soils have become more acid. Acid rain (wet deposited acidity) is a negligible source, but total atmospheric deposition may comprise up to 30% of acidifying inputs at near neutral soil pH values and more as soil pH decreases. Excepting fertilizers, the greatest causes of soil acidification at or near neutral pH values are the natural inputs of H+ from the dissolution of CO2 and subsequent dissociation of carbonic acid, and the mineralization of organic matter.Under grassland, single superphosphate and small amounts of sodium and magnesium sulphates have had no effect on soil pH, whilst potassium sulphate increased soil acidity slightly. All of these effects are greatly outweighed under grassland, however, by those of nitrogen fertilizers. Against a background of acidification from atmospheric, crop and natural inputs, nitrogen applied as ammonium sulphate decreased soil pH up to a maximum of 1.2 units at a rate in direct proportion to the amount added, and nitrogen applied as sodium nitrate increased soil pH by between 0.5 and 1 unit.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 9 (1986), S. 0 
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Growth of barley (Hordeum vulgare L., cv. Georgie) was insensitive to soil K content above about 150 mg kg−1, but at lower levels it declined. The reduction in yield was greater in soils containing approximately 10 mg Na kg−1 than in soils with about 90 mg kg−1 of Na. Growth was unaffected by changes in shoot K concentration above 75 mol m−3, but declined at lower concentrations, and the decrease was less in plants grown in soils with high Na. Growth responses were not simply related to tissue K concentrations because plants grown in soils with extra Na had higher yields but lower K concentrations.When soil Na was low, plants accumulated Ca as tissue K declined, but when Na was provided this ion was accumulated. Plant Mg concentrations were generally low but increased as K decreased. The Ca and Mg were osmotically active. There were highly significant inverse linear relationships between yield and either the Ca or Mg concentrations in the shoots.X-ray microanalysis was used to examine the compartmentation of cations in leaves from barley plants (cv. Clipper) grown in nutrient solutions with high and low K concentrations. In plants grown with 2.5 mol m−3 K, this was the major cation in both the cytoplasm and vacuole of mesophyll cells. However, in plants grown with 0.02 mol m−3 K it declined to undetectable levels in the vacuole, although it was still detectable in the cytoplasm. In all plants, Ca was mainly located in epidermal cells. The implication of the results for explaining responses to K. in terms of compartmentation of solutes is discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 9 (1986), S. 0 
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract A comparison of some of the methods used to determine whether aquatic plants have the ability to utilize bicarbonate ions as a source of inorganic carbon for photosynthesis has been applied to the intertidal macroalga Ascophyllum nodosum. These include: observing photosynthesis at a high pH (below the alga's CO2 compensation point), pH compensation point determinations, comparing the photosynthetic characteristics at low pH (5.20) and at high pH (7.95), estimating the maximal rates at which CO2 can diffuse through the unstirred layer and the rate at which CO2 can be produced from bicarbonate dehydration in the unstirred layer. All indicated that Ascophyllum nodosum can use bicarbonate ions for photosynthesis, though some were not always consistent. Calculating the total inorganic carbon concentration from pH measurements and acidification CO2 determinations revealed that the assumption that the alkalinity remains constant during pH drift experiments is not always valid.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Strains of Rhizobium leguminosarum biovar viciae specifically make an abundant protein (Rhi) in free-living culture but not in bacteroids. Genes needed for Rhi synthesis are on a Sym plasmid and here we show that one of these genes, rhiA, is the structural gene that specifies this polypeptide. Transcription of rhiA requires a regulatory gene, rhiR, located close to rhiA and to nod genes involved in nodulation. Mutations in rhiA or rhiR do not appear to affect symbiotic nitrogen fixation. Transcription of rhiA is repressed in cells grown in the presence of the flavanone hesperetin or the flavone apigenin, both of which are potent inducers of transcription of nod genes. This was deduced from the use of rhiA-lacZ fusions; however, when the Rhi polypeptide was detected in SDS gels, there was no apparent difference in the intensity of its staining in extracts obtained from cells grown with or without these flavanoid nod gene inducer molecules. However, a mutation in a nodulation gene, nolR, also closely linked to the nod and rhi genes, caused a severe depression in the amount of Rhi (as seen on gels) that was made in cells grown in the presence of inducer flavanoids.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 3 (1989), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: nodD of Rhizobium leguminosarum has two regulatory properties: it autoregulates and, in cells grown with specific flavonoids, activates other nod genes. We isolated mutations in nodD affecting one or both properties. Those abolishing autoregulation and nod gene induction were at the 5′ end of nodD, as were those which only affected autoregulation. Mutations affecting nod gene activation are at the 3’end of nodD. Eleven mutations in this region of nodD were isolated: some had little effect on the regulatory properties; others reduced activation of other nod genes. 265 bps were removed from the 3’end of nodD: this abolished nodD function. Doubly mutant derivatives of nodD were constructed by making nodD genes with a mutation that conferred the ability to activate transcription of nod genes in the absence of inducers (class IV) plus another that abolished autoregulation and/or flavonoid-dependent nod gene activation. The behaviour of such double mutants was complex; e.g. in one case, a doubly mutant nodD gene containing the class IV mutation, coupled to one of those that (alone) abolished autoregulation and nod gene induction, was similar in behaviour to the wild type. In other cases, double mutants were similar to one of the parentals.
    Type of Medium: Electronic Resource
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