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Combined immunohistochemical study of tissue polypeptide antigen and cancer antigen 125 in human ovarian tumours (1990)

GHAZIZADEH, M. ; SASAKI, Y. ; OGURO, T. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Histopathology 17 (1990), S. 0

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ISSN: 1365-2559

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: An indirect immunoperoxidase method was used to study the expression of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA 125) in 47 benign and malignant ovarian tumours. Tissue polypeptide antigen and CA 125 antigen were expressed respectively in 22 (73%) and 16 (53%) of the 30 adenocarcinomas and in five (29%) and four (23%) of the 17 benign tumours. Co-expression of TPA and CA 125 antigen occurred in 12 (40%) malignant and four (23%) benign tumours. Ultrastructurally, TPA and CA 125 antigens were located at the cell surface and microvillous surfaces.Evaluation of combined TPA and CA 125 antigen results revealed a remarkable improvement in the positivity rate and a significant decrease (P〈0.05) in the negativity rate of ovarian carcinomas as compared with the result of each one separately. These findings provide complementary evidence for the previous results on the plasma levels of TPA and CA 125 antigen and suggest that specific combinations of tumour markers may be more effective for the diagnosis and monitoring of ovarian carcinomas, than the use of any single marker.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2559.1990.tb00682.x

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Ion exchange separation of trace amounts of uranium and thorium in tantalum for neutron activation analysis (1990)

Sasaki, Y. ; Takeishi, H. ; Adachi, T. ; [et al.]

Springer

Journal of radioanalytical and nuclear chemistry 139 (1990), S. 143-151

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ISSN: 1588-2780

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering

Notes: Abstract Separation method of a few ppb of uranium and thorium in tantalum metal by ion exchange for neutron activation analysis was established. After dissolving tantalum metal by hydrofluoric acid, uranium and thorium were separated from tantalum using cation exchange resin column in 0.5M hydrofluoric −0.65M boric acid media. Both of the yields for uranium and thorium during separation were above 95% and the remaining amount of tantalum be lowered below 400 ng.