ISSN:
1432-069X
Keywords:
γδ TCR+ cells
;
Human skin
;
Immunohistochemistry
;
Delayed-type hypersensitivity reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In order to investigate the distribution and involvement of human γδ T-cell receptor-positive (TCR+) cells in delayed-type hypersensitivity reactions of the skin, we examined the occurrence and kinetics of γδ TCR+ cells during skin reactions of allergic contact dermatitis. In normal human skin sections, γδ TCR+ cells were scarce. In allergic contact dermatitis from DNCB, increased γδ TCR+ cells were observed both in the epidermis and in the dermis from 48 h after the challenge. Most of the γδ TCR+ cells were TCRδ1+ δTCS1− BB3+ TiγA+ (Vδ1− Vδ2+ Vγ9+). The percentage of γδ TCR+ cells in the peripheral blood remained unchanged and a few γδ TCR+ cells in the skin lesions proliferated in situ. It is suggested that the γδ TCR+ cells in skin lesions of allergic contact dermatitis may not be involved in initiation of delayed-type hypersensitivity but may have some other roles responding to factors induced in the reaction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00372140
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