ISSN:
1573-6903
Keywords:
l-deprenyl
;
rat
;
monoamine oxidase
;
sex differences
;
dosing method
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The monoamine oxidase B (MAO-B) inhibitorl-deprenyl, widely used to treat Parkinson's disease, has frequently been studied in animal models. We have examined the effects of several variables on activity levels of MAO-A and B in rat brain and liver following chronic (3 wks) treatment withl-deprenyl. Significant effects were observed for sex (females showed lower overall MAO-B activity in the liver), dose (MAO-A and B inhibition increased with dose, with females exhibiting greater sensitivity), route of administration (subcutaneous injection was more efficient than oral dosing), and dosing interval (MAO-B was significantly inhibited when dosing interval was increased to as long as 168 hours). Our results thus indicate that the effectiveness ofl-deprenyl in vivo is dependent on several factors and that these must be taken into account in studies involving the benefits or risks of this drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00975051
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