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  • 1990-1994  (4)
  • 1955-1959
  • 1900-1904
  • 1993  (4)
Materialart
Erscheinungszeitraum
  • 1990-1994  (4)
  • 1955-1959
  • 1900-1904
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Environmental science & technology 27 (1993), S. 1918-1923 
    ISSN: 1520-5851
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Energietechnik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 44 (1993), S. 63-67 
    ISSN: 1432-1041
    Schlagwort(e): Mexiletine ; Debrisoquine hydroxylation phenotype ; pharmacokinetic ; variability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine-type may have on mexiletine pharmacokinetics was considered in this study. The pharmacokinetics and urinary excretion of mexiletine (250 mg administered intravenously) were investigated in 5 rapid extensive metabolisers (EM), 5 slow EM and 5 poor metabolisers (PM) of debrisoquine, under conditions of controlled urinary pH. Mexiletine disposition kinetics was found to be altered in PM individuals. These subjects showed higher total area under the curve (AUC), (15.7 versus 8.16 μg · h · ml−1) prolonged elimination half-lives (in serum and urine) (serum: 18.5 versus 11.6 h, urine: 19.2 versus 11.7 h) and lower total clearance values compared with EM (216 versus 450 ml · min−1). In this respect, slow EM individuals generally presented intermediate values of those pharmacokinetic parameters. A higher incidence of adverse-effects was also observed among slow EM and PM subjects. It is concluded that genetic differences in mexiletine oxidation of the debrisoquine-type have an influence on its observed pharmacokinetic variability. The clinical consequences are discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Contributions to mineralogy and petrology 114 (1993), S. 365-378 
    ISSN: 1432-0967
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract We report the result of H2O-undersaturated melting experiments on charges consisting of a layer of powdered sillimanite-bearing metapelite (HQ36) and a layer of powdered tonalitic gneiss (AGC150). Experiments were conducted at 10 kbar at 900°, 925° and 950°C. When run alone, the pelite yielded ∼40 vol% strongly peraluminous granitic melt at 900°C while the tonalite produced only ∼5 vol% weakly peraluminous granitic melt. At 950°C, the pelite and the tonalite yielded ∼50 vol% and ∼7 vol% granitic melt, respectively. When run side by side, the abundance of melt in the tonalite was ∼10 times higher at all temperatures than when it was run alone. In the pelite, the melt abundance increased by ∼25 vol%. When run alone, biotite dehydration-melting in the tonalite yielded orthopyroxene and garnet in addition to granitic melt. When run side by side only garnet was produced in addition to granitic melt. Experiments of relatively short duration, however, also contained Al-rich orthopyroxene. We suggest that the large increase in melt fraction in the tonalite is mainly a result of increased activity of Al2O3 in the melt, which lowers the temperature of the biotite dehydration-melting reaction. In the pelite, the increase in the abundance of melt is caused by transport of plagioclase component in the melt from the tonalite-layer to the pelite-layer. This has the effect of changing the bulk composition of this layer in the direction of “minimum-temperature” granitic liquids. Our results show that rocks which are poor melt-producers on their own can become very fertile if they occur in contact with rocks that contain components that destabilize the hydrous phase(s) and facilitate dehydration-melting. Because of this effect, the continental crust may have an even greater potential for granitoid melt production than previously thought. Our results also suggest that many anatectic granites most likely contain contributions from two or more different source rocks, which will be reflected in their isotopic and geochemical compositions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Experimental brain research 93 (1993), S. 293-298 
    ISSN: 1432-1106
    Schlagwort(e): Medial vestibular nucleus ; 5-Hydroxytryptamine ; Serotonin ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of 5-hydroxytryptamine (5-HT) and related compounds on the discharge rate of tonically active medial vestibular nucleus (MVN) neurones were studied in an in vitro slice preparation of the dorsal brainstem of the rat. The majority (87 of 107, 82%) of MVN neurones were excited by 5-HT. Nine cells (8%) showed a biphasic response to 5-HT, which consisted of a brief inhibition followed by excitation. Eleven cells (10%) were inhibited by 5-HT. The excitatory effects of 5-HT were mimicked by alpha-methyl-5-HT and antagonised by ketanserin and ritanserin, indicating the involvement of the 5-HT2 subtype of 5-HT receptor. In biphasic cells, blockade of 5-HT2 receptors by ketanserin reduced the excitatory component of the response and revealed an enhanced initial inhibition. The inhibitory effects in biphasic cells, and in cells that showed a pure inhibition in response to 5-HT, were blocked by pindobind-5-HT and mimicked by 8-hydroxy-2-(di-n-propylamino)-tetralin indicating the involvement of 5-HT1A receptors. The significance of these findings in relation to the effects of 5-HT on vestibular reflex function is discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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