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  • 1
    Digitale Medien
    Digitale Medien
    Microphase separation in thin films of the symmetric diblock-copolymer melt (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 3367-3377 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: By means of Monte Carlo simulations of a lattice model, microphase separation transition of symmetric diblock-copolymer melts confined in the thin-film geometry between parallel hard walls is studied. We impose a surface field which acts repulsively only on one of the two species, to stabilize lamellar order parallel to the surfaces. However, interplay between two characteristic lengths, that is, the natural thickness of the lamellar l and the thickness of the film D, causes complicated behavior. In case that the two lengths are compatible with each other, clear lamellar order parallel to the surfaces is observed at temperatures lower than the bulk transition temperature, as expected. On the other hand, tilted or deformed lamellar structure, or even coexistence of lamellae in different orientations are found in cases of strong conflict. In both cases, lamellae are fully established. Even at temperature higher than the bulk transition temperature, weak order is induced by the surface field, and a gradual transition between such surface-induced order and bulklike order is observed. Film thickness and temperature dependence of the ordered structure is discussed, as well as a density reduction near the walls and in the interfaces between the segregated regions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.467584
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  • 2
    Digitale Medien
    Digitale Medien
    Heterogeneity of Epstein-Barr virus infection in angioimmunoblastic lymphadenopathy type T-cell lymphoma (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: To investigate the relationship of Epstein-Barr virus (EBV) and angioimmunoblastic lymphadenopathy with dysproteinemia, we performed DNA analysis using the polymerase chain reaction (PCR), Southern blot, in situ hybridization, and immunohistochemical analysis of lymph nodes in five patients who were followed up and biopsied more than once. In the course of the disease, nodal architecture diminished, cellular atypia worsened, and clear cells increased in number. In the DNA analysis of the receptor genes, the clonal population increased in number. EBV nucleic acid sequences were found by either PCR or in situ hybridization in all examined nodes. The number of EBV-positive cells varied widely among the cases and throughout the course of the disease in the same patients. The analysis of EBV terminal repeats or lymphocyte-determined membrane antigen genes showed polyclonal populations of EB-infected cells. EBV-positive cells possessed intermediate- to large-sized nuclei, and the cells with large nuclei, especially, expressed latent membrane protein of EBV. These large cells varied in number among the cases. Double-labelling immunohistochemistry/in situ hybridization studies demonstrated that most of the EBV-positive cells expressed B-cell antigen (CD20). The presence of EBV seems to be associated with the selective defects of the immune system, rather than with the direct pathogenesis of angioimmunoblastic lymphadenopathy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01376.x
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  • 3
    Digitale Medien
    Digitale Medien
    Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 883-886 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Epstein-Barr virus ; Epstein-Barr virus encoded RNA-1 ; Budd-Chiari syndrome ; Plasmacytoma ; Interleukin 2
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00190746
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  • 4
    Digitale Medien
    Digitale Medien
    Genetic changes in atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia in the same patients (1994)
    Springer
    Virchows Archiv 425 (1994), S. 25-32 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Angioimmunoblastic lymphadenopathy with dysproteinaemia ; Polymerase chain reaction ; T-cell receptor gene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The transition between atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia (AILD) was studied in serial lymp node biopsy specimens from five patients using DNA analysis with Southern blot analysis, polymerase chain reaction, chromosomal analysis, and immunophenotyping. The chromosomal analysis showed additional abnormalities as the disease progressed to those present initially, and immunological staining showed a corresponding increase in the numbers of CD4- and Ki67-positive cells. In the first biopsy from each patient a diagnosis of atypical hyperplasia with AILD was made and lymphoma excluding by the finding of only a few atypical lymphoid cells and the preservation of follicles with germinal centres. DNA analysis of lymph nodes at this stage showed either germ lines or oligoclonal rearrangements of the T-cell receptor (TCR) and immunoglobulin heavy chain genes. In the final biopsy, when a diagnosis of lymphoma with AILD was made, either a monoclonal rearrangement of the TCR was observed or one of the rearranged bands had increased in density. These results suggest selective proliferation of a clone of abnormal cells may account for the progression of atypical hyperplasia to lymphoma with AILD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00193945
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  • 5
    Digitale Medien
    Digitale Medien
    Early malignant histiocytosis of the intestine: an autopsy report (1994)
    Springer
    Virchows Archiv 424 (1994), S. 327-330 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Autopsy ; Early malignant histiocytosis of the intestine ; Cell clonality ; Polymerase chain reaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 63-year-old man with malignant histiocytosis of the intestine died 3 days after gastrectomy for early gastric adenocarcinoma. Malignant histiocytosis of the intestine was unexpectedly found at autopsy. The intestine was thickened with mucosal erosions. Histologically, a few atypical large histiocyte-like cells were found in focal aggregates in the mucosa. These large cells expressed the T-cell antigen and monoclonality was demonstrated by the polymerase chain reaction showing variable-joining segment rearrangement in the T-cell receptor delta-chain gene. Malignant histiocytosis of the intestine was thus diagnosed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00194619
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  • 6
    Digitale Medien
    Digitale Medien
    Analysis of herpesvirus genomes in Kikuchi's disease (1994)
    Springer
    Virchows Archiv 424 (1994), S. 437-440 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Kikuchi's disease ; Herpes virus ; Lymph node
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined the cervical lymph nodes of 30 patients with Kikuchi's disease and 15 patients with nonspecific lymphadenitis, using Southern blot analysis and polymerase chain reaction (PCR) to identify human herpesviruses such as Epstein-Barr virus (EBV), cytomegalovirus, herpes simplex virus, and varicella-zoster virus. By Southern blot analysis, no virus DNA was recognized, but 16 of the 30 nodes from patients with Kikuchi's disease and 8 of the 15 nodes from patients with non-specific lymphadenitis showed amplified EBV DNA by PCR.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00190567
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  • 7
    Digitale Medien
    Digitale Medien
    Analysis of adhesion molecules in Ki-1 anaplastic large-cell lymphoma (1994)
    Springer
    Virchows Archiv 425 (1994), S. 33-39 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Ki-1 anaplastic large-cell lymphoma Adult T-cell leukaemia/lymphoma ; ATLL ; Adhesion molecules
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We analysed the expression of adhesion molecules on lymphoma cells in 13 patients with Ki-1 (CD30)-positive anaplastic large-cell lymphoma (Ki-1 ALCL; lymph nodes in 6, extranodal tumours in 6, and both lymph nodes and bone in 1). Very late activation antigen (VLA)-α4 (CD49d) and Hermes lymph node homing receptor (CD44) were constantly expressed in all specimens, and intercellular adhesion molecule-1 (ICAM-1; CD54) was frequently expressed in 10 of the 14 specimens. The expressions of lymphocyte function-associated antigen-1α (LFA-1α; CD11a) and VLA-α5 (CD49e) occurred in 5 of 14 and 4 of 14 specimens, respectively. The expressions of VLA-α2 (CD49b), endothelial leukocyte adhesion molecule-1, neural cell adhesion molecule (CD56) and E cadherin were always lacking. VLA-α6 (CD49f) was absent in all but one specimen. The expression of VLA-α5 on Ki-1 ALCL was high in subcutis-cutis but absent in lymph nodes. Furthermore, in one case, LFA-1α was detected in the primary lymph node, but was absent in a metastatic bone lesion. These results suggest that the expression of ICAM-1 is partially responsible for aleukemic behaviour in Ki-1 ALCL and, moreover, that the Ki-1 ALCL cells modify their expression of adhesion molecules at each of the involved organs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00193946
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  • 8
    Digitale Medien
    Digitale Medien
    Expression of human T-cell leukaemia virus type I and associated antigens, and interleukin-2 and receptor in lymph nodes of adult T-cell leukaemia/lymphoma (1994)
    Springer
    Virchows Archiv 425 (1994), S. 249-258 
    Details
    ISSN: 1432-2307
    Schlagwort(e): HTLV-I ; mRNA ; Gene products ; Lymph node
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To examine the relationship between the expression of human T-cell leukaemia virus type (HTLV-I) mRNA and associated antigens and clinicopathological features, we studied 31 lymph nodes of patients with adult T-cell leukaemia/lymphoma (ATLL) and related diseases, using in situ hybridization and immunohistochemistry. We classified the patients into four types on the basis of their clinicopathological features (HTLV-I associated lymphadenitis, incipient ATLL, ATLL with complete HTLV-I provirus, and ATLL with defective HTLV-I provirus. The expression of HTLV-I mRNA was detected in all 3 patients with incipient ATLL, in 5 of 10 patients with defective-provirus ATLL, in 5 of 11 patients with complete-provirus ATLL, and 3 of 7 with HTLV-I associated lymphadenitis, but the amounts were very small; approximately 1 in 10000–200000 lymph node cells express the viral genomes. This suggests that expression of viral genomes may not be important for immortalization, but it is important that to note the capacity for HTLV-I infection is preserved in each group of non-neoplastic and neoplastic states. HTLV-I mRNA was detected only in lymphocytes and/or lymphoma cells, but the HTLV-I associated antigens (env, gag and pX) were found in histiocytes and endothelial cells, as well as in lymphocytes and/or lymphoma cells. Anti-interleukin 2 receptor (IL-2R) antibody reacted with the giant cells of incipient ATLL and with the transformed lymphocytes and immunoblast-like cells of the HTLV-I-associated lymphadenitis but not with the lymphocytes in the background. Of the typical ATLL, IL-2R was found in both lymphoma cells and giant cells. IL-2 was rarely detected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00196147
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  • 9
    Digitale Medien
    Digitale Medien
    Cervical spinal cord injury associated with ossification of the posterior longitudinal ligament (1994)
    Springer
    Archives of orthopaedic and trauma surgery 113 (1994), S. 218-221 
    Details
    ISSN: 1434-3916
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Among 231 patients with cervical injuries treated over 12 years, 15 had cervical spinal cord injury associated with ossification of the posterior longitudinal ligament. All of them were male and most had injuries due to a relatively weak external force. Four of them underwent surgery. There was little difference in improvement of paralysis between the conservatively and the surgically treated group.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441836
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  • 10
    Digitale Medien
    Digitale Medien
    Monte carlo studies of phase transitions in polymer blends and block copolymer melts (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 653-660 
    Details
    ISSN: 0392-6737
    Schlagwort(e): Macromolecular and polymer solutions (solubility, swelling, etc.) ; polymer melts ; Critical point phenomena ; Liquid-liquid transitions ; Monte Carlo and statistical methods ; Conference proceedings
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Summary The unmixing transition of both symmetrical polymer blends AB (i.e. chain lengthsN A=N B=N) and asymmetrical ones (N B/N A=2,3) is studied by large-scale Monte Carlo simulations of the bond fluctuation model. Combination of semi-grand-canonical simulation techniques, «histogram reweighting» and finitesize scaling allows an accurate location of the coexistence curve in the critical region. The variation of the critical temperature with chain length (N) is studied and compared to theoretical predictions. For the symmetrical case, use of chain lengths up toN=512 allows a rough estimation of crossover scaling functions for the crossover from Ising to mean-field exponents. The order-disorder transitions in melts of both symmetric (compositionf=N A/(N A+N B)=1/2) and asymmetric (f=3/4) block copolymers is studied for very short chains (16≤N≤60). The interplay between structure and chain configuration is emphasized. Qualitative evidence for «dumbell formation» of chains and vacancy enrichment in A-B-interfaces and near hard walls is presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02456709
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