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  • 1995-1999  (1)
  • 1990-1994  (1)
  • 1945-1949
  • 1995  (1)
  • 1991  (1)
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  • 1995-1999  (1)
  • 1990-1994  (1)
  • 1945-1949
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  • 1
    Electronic Resource
    Electronic Resource
    Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607 (1991)
    [s.l.] : Nature Publishing Group
    Nature 352 (1991), S. 168-172 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The three-dimensional structure of MerA from Bacillus sp. strain RC607 can be clearly divided into three parts: the two N-terminal regions (residues 1-166), the core (167-616), the equivalent of the glutathione reductase structure, and the C-terminal extension (residues 617-631). This partition is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/352168a0
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A clinical and pharmacological study of 5-fluorouracil, leucovorin and interferon alfa in advanced colorectal caner (1995)
    Springer
    Cancer chemotherapy and pharmacology 37 (1995), S. 86-90 
    Details
    ISSN: 1432-0843
    Keywords: Key words 5-Fluorouracil ; Interferon ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Modulation of 5-fluorouracil (FUra) using leucovorin (LV) is a standard treatment approach in patients with metastatic colorectal cancer. Modulation of FUra with interferon alfa has also shown some promise. Laboratory data have demonstrated increased cytotoxicity when FUra is combined with both LV and interferon. The current study examined the effects of double modulation of FUra using LV and interferon.Patients with measurable advanced colorectal cancer received bolus FUra 375 mg/m2 plus LV 20 mg/m2 daily for 5 days, repeated every 28 days. Recombinant human interferon alfa-2a, 3 million IU/m2 subcutaneously, was given daily on the days of chemotherapy then three times weekly. There was one complete response and nine partial responses (10/41) seen for an overall response rate of 24% (95% CI 12.0–40.0%). Overall, 70% of patients experienced one or more episodes of nonhematologic toxicity of grade 3 or more. Weight loss was common, with a mean decrease of 2.9 kg over the first two months (P〈0.0001). Improvements in tumor-related symptoms were balanced by increased fatigue and a deterioration in body weight and performance status. There was no evidence of progressive changes in FUra metabolism from interferon usage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050371
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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