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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 145 (1995), S. 233-244 
    ISSN: 1432-1424
    Keywords: Ca2+ current ; Arachidonic acid ; Myristic acid ; Tetradecyltrimethylammonium ; Sphingosine ; Neuroblastoma x glioma hybrid cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Low-voltage-activated (1-v-a) and high-voltage-activated (h-v-a) Ca2+ currents I Ca were recorded in whole-cell voltage clamped NG108-15 neuroblastoma x glioma hybrid cells. We studied the effects of arachidonic acid (AA), oleic acid, myristic acid and of the positively charged compounds tetradecyltrimethyl-ammonium (C14TMA) and sphingosine. At pulse potentials 〉−20 mV, AA (25-100 μm) decreased 1-v-a and h-v-a I Ca equally. The decrease developed slowly and became continually stronger with increasing time of application. It was accompanied by a small negative shift and a slight flattening of the activation and inactivation curves of the 1-v-a I Ca. The shift of the activation curve manifested itself in a small increase of 1-v-a I Ca at pulse potentials 〈−30 mV. The effects were only partly reversible. The AA effect was not prevented by 50 μm 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of the AA metabolism, and not mimicked by 0.1–1 μm phorbol 12, 13-dibutyrate, an activator of protein kinase C. Probably, AA directly affects the channel protein or its lipid environment. Oleic and myristic acid acted similarly to AA but were much less effective. The positively charged compounds C14TMA and sphingosine had a different effect: They shifted the activation curve of 1-v-a I Ca in the positive direction and suppressed 1-v-a more than h-v-a I Ca; their effect reached a steady-state within 5–10 min and was readily reversible. C14TMA blocked 1-v-a I Ca with an IC50 of 4.2 μm while sphingosine was less potent.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 245 (1995), S. 299-305 
    ISSN: 1433-8491
    Keywords: Frontal lobe degeneration ; Dementia ; Non-Alzheimer type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report six cases of presenile (five) and senile (one) progressive dementia with a mild-to-marked frontal or frontotemporal atrophy and ventricular dilation (Frontal Lobe Degeneration [FLD]). The most prominent microscopic features were layer-dependet neuronal depletion of the cortex, spongiosis, and cortical and subcortical gliosis. Five cases showed additional degeneration of the S. nigra, and two also had motor neuron disease. Despite the absence of Pick cells and bodies, such cases have many features in common with Pick atrophy. Because Pick cells and bodies are inconstantly occurring features in other-wise typical cases of Pick atrophy, they cannot be regarded as inevitable markers of the latter. In our opinion, cases with mild frontal or frontotemporal atrophy as described herein and by others match the grades 1 and 2 in terms of Schneider's classification of Pick atrophy [37]. As long as the etiology of both Pick atrophy and the socalled FLD is unknown, and we finally have to follow morphological criteria for classification, there is apparently no convincing reason to introduce a separate category, such as FLD or FTA, for the cases with moderate or mild frontal atrophy and dementia of frontal lobe type, which can be sufficiently classified with the Pick spectrum of lobar atrophy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 97 (1995), S. 83-93 
    ISSN: 1434-6036
    Keywords: 79.60 ; 71.20 ; 71.28
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have investigated hole doped (by lithium) and electron-doped (by nickel metal) NiO with photoemission (PES), inverse photoemission (IPES) and low and high energy electron energy loss spectroscopy (EELS). Both types of doping create empty states approximately in the middle of the charge transfer gap of undoped NiO.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Während viele Berichte belegen, daß Pertussis eine häufige Krankheit auch im Erwachsenenalter ist, gibt es nur wenige Studien zum klinischen Verlauf der Krankheit jenseits der Kindheit. Im Rahmen einer Haushalt-kontaktstudie zum Nachweis der Wirksamkeit einer azellulären Pertussis-Vakzine wurden in einem Studienzentrum mit bekannt niedriger Pertussis-Durchimpfungsrate Erwachsene mit Keuchhusten identifiziert und Symptome erfragt. Innerhalb von 2 Jahren wurden 257 Patienten mit Pertussis in 121 Familien gefunden. Davon waren 79 Erwachsene (30,7%) im Alter zwischen 19 und 83 Jahren (Durchschnittsalter: 36 Jahre). Das Verhältnis männlich zu weiblich betrug 1:1,8. Husten wurde von 91% der Erwachsenen angegeben (durch-schnittliche Dauer: 54 Tage). Er dauerte in 80% der Fälle ≥ 21 Tage an. Inspiratorischer Stridor war selten (8%), dagegen war der Husten häufig von Erbrechen und/oder Würgreiz gefolgt (53%) oder störte den Schlaf der Patienten (52%). Dies ist die erste Studic, in der anfallsweise auftretender Schweißausbruch als Symptom bei Pertussis beschrieben wird (14%). Über pharyngeale Symtome, (37%), Influenza-ähnliche Symptome (30%), Niesanfälle (22%), Heiserkeit (18%), schmerzhafte Sinus (16%) und Kopfschmerzen (14%) wurde ebenfalls berichtet. Komplikationen wurden bei 23% der erwachsenen Patienten beobachtet. Unabhängig vom Alter sollte die mikrobiologische Diagnostik bei allen symptomatischen Kontaktpersonen eines Patienten mit Pertussis und ebenso bei jedem Patienten mit lang anhaltendem Husten konsequent durchgeführt werden, damit die weitere Ausbreitung des Erregers zu einem möglichst frühen Zeitpunkt verhindert werden kann.
    Notes: Summary There is increasing evidence that pertussis occurs frequently in adults, but there is limited information on the clinical course of this disease beyond childhood. A household contact study on the efficacy of an acellular pertussis vaccine was used to study the symptoms of pertussis in adults. Among 257 patients with pertussis identified in 121 families during a two-year period in one study center with a low whole-cell pertussis-vaccine uptake, 79 (30.7%) were adults, aged 19–83 years (mean age: 36 years) with a 1:1.8 male to female ratio. Ninety-one percent of the adults suffered from coughing (mean duration: 54 days), and in 80% this cough lasted ≥ 21 days. Whoops were rare (8%), whereas cough followed by vomiting and/or choking (53%) and cough disturbing sleep (52%) were common. This is the first report to describe sweating attacks as symptom of pertussis (14%). Pharyngeal symptoms (37%), influenza-like symptoms (30%), sneezing attacks (22%), hoarseness (18%), sinus pain (16%) and headaches (14%) were also observed. Various complications were seen in 23% of the patients. In order to minimize the spread of the organism, micro-biological diagnostics should be vigorously applied to all symptomatic contacts of a patient with pertussis but also to all patients with long lasting cough — irrespective of age.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 99 (1995), S. 421-423 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Experimental results on the optical absorption in Li doped NiO are presented. Upon Li doping, considerable oscillator strength is found to appear throughout the fundamental absorption gap until at 2% doping the d-d excitations usually observed within the gap are completely overwhelmed by these new excitations. Low energy REELS measurements on the same set of samples do not show the same behaviour. We briefly discuss the compatibility of our findings with results of previous electron spectroscopic results and with theoretical scenarios.
    Type of Medium: Electronic Resource
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