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  • 1
    Electronic Resource
    Electronic Resource
    Filopodia and growth cones in the vertically migrating granule cells of the postnatal mouse cerebellum (1997)
    Springer
    Experimental brain research 117 (1997), S. 17-29 
    Details
    ISSN: 1432-1106
    Keywords: Key words Filopodia ; Growth cone ; Laser scanning confocal microscopy ; Perpendicular contact guidance ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The details of the morphology of vertically migrating granule cells were examined semiquantitatively in the postnatal mouse cerebellum by a Golgi method, with special reference to the growth cone-related structures such as filopodia and lamellipodia. The first sign of inward migration was extension of short, vertical filopodium-like processes from the sides of the perikarya of tangentially oriented granule cells, followed by a change of orientation of cell bodies to the vertical axis showing a T-shaped morphology. The T-shaped migratory cells formed sprouted filopodia (side spikes) from their vertical leading processes and perikarya at right angles to the vertical axis. More than three-quarters of the migratory cells extended the side spikes. The presence of such side spikes was confirmed with laser scanning confocal microscopy of granule cells labeled with 1,1′, dioctadecyl-3,3,3′,3-tetramethylindocarbocyanine perchlorate and also with transmission electron microscopy (TEM). In addition, about one-fourth of migratory cells extended lamellipodia of web-like forms along the stem or at the tip of the leading process, some of which showed a typical growth cone. Several morphological variations of vertical granule cells were also observed. Furthermore, TEM observation confirmed that side spikes from migratory cells made direct contact with parallel fibers. The present results suggest that, during vertical migration, growth cone-related structures of the leading processes of granule cells adhere to and probably recognize tangentially oriented parallel fibers. Therefore, the mechanisms of the vertical guidance and migration of granule cells in the cerebellar cortex seem to be multiple, involving not only parallel contact guidance by the Bergmann glia fibers but also perpendicular contact guidance by the parallel fibers. These parallel and perpendicular geometric cues surrounding the granule cells seem to have produced the varying morphology of vertically migrating granule cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005787
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of T-cell epitope sequences on an important mite antigen (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background T-cell epitopes on Der 1 and Der 2 groups, the major mite allergens, have been intensively analysed, while those on the other important allergens remain to be elucidated. We have cloned four cDNAs coding for important mite allergens on the basis of frequency and capacity of IgE binding. Stimulatory action of glutathione S-transferase-fused Mag1 on lymphocytes from mite-allergic patients was relatively high among them.Objective To identify T-cell epitopes on Mag1, we studied the stimulating activity of truncated Mag1 proteins and synthetic peptides on proliferative response of lymphocytes from mite antigen-immunized mice and mite-sensitive patients.Methods Truncated Mag1 proteins were expressed as a fusion protein with β-galactosidase in Escherichia coli pop2136 carrying a variety of deleted Mag1 inserts. Murine T-cell epitope regions were estimated by the truncated antigen-induced lymphocyte proliferation assay. Overlapping peptides covering the whole sequence of the presumed T-cell epitope regions were synthesized to identify the epitope core. sequences using murine and human Mag1-specific T-cell lines.Results Amino acid range 56–70 on Mag1 molecule showed remarkable stimulatory action on murine T cells, while amino acid ranges 51–65 and 86–100 had potent stimulatory activity on human T cells.Conclusion These results suggest that Mag1 is a valuable antigen suitable for studies on T-cell responses and T-cell epitopes in mice and humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb01261.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cytomegalovirus-associated myelodysplasia and thrombocytopenia in an immunocompetent adult (1997)
    Springer
    Annals of hematology 74 (1997), S. 99-101 
    Details
    ISSN: 1432-0584
    Keywords: Key words Adult ; Cytomegalovirus ; Myelodysplasia ; Thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Myelodysplasia and severe thrombocytopenia in association with cytomegalovirus (CMV) infection in immunocompetent adults have rarely been reported. We describe a previously healthy man who developed severe thrombocytopenia with myelodysplastic changes of bone marrow and multiple autoimmune abnormalities following CMV infection. We also discuss possible mechanisms leading to myelodysplasia and thrombocytopenia in CMV infection. We believe that CMV infection should be considered in the differential diagnosis of myelodysplasia and acute thrombocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050265
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  • 4
    Electronic Resource
    Electronic Resource
    Twists of elliptic curves (1997)
    Springer
    Compositio mathematica 106 (1997), S. 349-360 
    Details
    ISSN: 1570-5846
    Keywords: elliptic curves ; modular forms.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract If E is an elliptic curve over $$\mathbb{Q}$$ , then let E(D) denote theD-quadratic twist of E. It is conjectured that there are infinitely many primesp for which E(p) has rank 0, and that there are infinitely many primes $$\ell $$ for which $$E(\ell )$$ has positive rank. For some special curvesE we show that there is a set S of primes p with density $$\frac{1}{3}$$ for which if $$D = \prod {p_j } $$ is a squarefree integer where $$p_j \in S$$ , then E(D) has rank 0. In particular E(p) has rank 0 for every $$p \in S$$ . As an example let E1 denote the curve $$E_1 :y^2 = x^3 + 44x^2 - 19360x + 1682384$$ . Then its associated set of primes S1 consists of the prime11 and the primes p for which the order of the reduction ofX0(11) modulo p is odd. To obtain the general result we show for primes $$p \in S$$ that the rational factor of L(E(p),1) is nonzero which implies thatE(p) has rank 0. These special values are related to surjective $$\mathbb{Z}/2\mathbb{Z}$$ Galois representations that are attached to modularforms. Another example of this result is given, and we conclude with someremarks regarding the existence of positive rank prime twists via polynomialidentities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1000191408511
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