Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Speech intelligibility following maxillectomy with and without a prosthesis: an analysis of 54 cases (1998)
    Oxford, UK : Blackwell Science, Ltd
    Journal of oral rehabilitation 25 (1998), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To statistically evaluate the factors that influenced speech following maxillectomy, the speech intelligibility (SI) in 54 patients was measured with and without a prosthesis. The mean SI score without a prosthesis in all patients was 35.7 ± 22.7% and that with a prosthesis was 84.9 ± 12.7%. The results of the postmaxillectomy SI statistical analysis revealed that an oro–nasal communication was one of the factors that influenced SI without a prosthesis. The resection of the anterior portion of the soft palate was one of the factors that influenced SI with a prosthesis, which suggested that for some of these patients we should consider specific surgical treatment, aimed at the reconstruction in the deep defect extending to the intratemporal fossa. A new classification of maxillary defects has been proposed which will help to predict the grade of postmaxillectomy speech disorder following surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.1998.00238.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Attenuation of weak shock waves along pseudo-perforated walls (1998)
    Springer
    Shock waves 8 (1998), S. 149-159 
    Details
    ISSN: 1432-2153
    Keywords: Key words:Weak shock waves, Sonic boom, Railway tunnel, Wall perforation, Holographic interferometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract. In order to attenuate weak shock waves in ducts, effects of pseudo-perforated walls were investigated. Pseudo-perforated walls are defined as wall perforations having a closed cavity behind it. Shock wave diffraction and reflection created by these perforations were visualized in a shock tube by using holographic interferometer, and also by numerical simulation. Along the pseudo-perforated wall, an incident shock wave attenuates and eventually turns into a sound wave. Due to complex interactions of the incident shock wave with the perforations, the overpressure behind it becomes non-uniform and its peak value can locally exceed that behind the undisturbed incident shock wave. However, its pressure gradient monotonically decreases with the shock wave propagation. Effects of these pseudo-perforated walls on the attenuation of weak shock waves generated in high speed train tunnels were studied in a 1/250-scaled train tunnel simulator. It is concluded that in order to achieve a practically effective suppression of the tunnel sonic boom the length of the pseudo-perforation section should be sufficiently long.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001930050108
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 177-183 
    Details
    ISSN: 1432-1041
    Keywords: Key words Zonisamide ; CYP3A4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The purposes of this study were to identify the P450 enzyme (CYP) responsible for zonisamide metabolism in humans by using expressed human CYPs and to predict drug interaction of zonisamide in vivo from in vitro data. Methods: Ten expressed human CYPs and human liver microsomes were used in the experiments for the identification of enzymes responsible for zonisamide metabolism and for the prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data, respectively. Two-sulfamoylacetyl phenol, a reductive metabolite of zonisamide, was measured by the HPLC method. Results: From the experiments using ten expressed human CYPs, CYP2C19, CYP3A4 and CYP3A5 were shown to be capable of catalyzing zonisamide reduction. However, an intrinsic clearance, Vmax/kM, of CYP3A4 was much higher than those of CYP2C19 and CYP3A5. From the point of view of enzyme amount in human liver CYPs isoform and their intrinsic clearance, it was suggested that CYP3A4 is mainly responsible for zonisamide metabolism in human CYPs. Zonisamide metabolism in human liver microsomes was markedly inhibited by cyclosporin A, dihydroergotamine, ketoconazole, itraconazole, miconazole and triazolam. We estimated the possibility and degree of change of zonisamide clearance in vivo in clinical dose range from in vitro inhibition constant of other drugs against zonisamide metabolism (Ki) and unbound inhibitor concentration in blood (Iu) in clinical usage. Clearance of zonisamide was maximally estimated to decrease by 31%, 23% and 17% of the clearance without inhibitors i.e. ketoconazole, cyclospolin A and miconazole, respectively. Fluconazole and carbamazepine are estimated to decrease by 5–6% of the clearance of zonisamide. On the other hand, there may be lack of interaction of zonisamide metabolism by dihydroergotamine, itraconazole and triazolam in clinical dose range. Conclusion: We demonstrated that: (1) zonisamide is metabolized by recombinant CYP3A4, CYP2C19 and CYP3A5, (2) the metabolism is inhibited to a variable extent by known CYP3A4/5 substrates and/or inhibitors in human liver microsomes, and (3) in vitro-in vivo predictive calculations suggest that several compounds demonstrating CYP3A4-affinity might cause in vivo drug-drug interactions with zonisamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050442
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A phase II study of cisplatin, oral administration of etoposide, OK-432 and radiation therapy for inoperable stage III non-small cell lung cancer (1998)
    Springer
    International journal of clinical oncology 3 (1998), S. 365-369 
    Details
    ISSN: 1437-7772
    Keywords: Stage III non-small cell lung cancer ; CDDP ; VP-16 ; Conventional radiotherapy ; Concurrent chemoand radiotherapy ; Accelerated proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. This study was designed to evaluate the feasibility and efficiency of giving cisplatin, etoposide, and OK432 concurrently with conventional radiotherapy (RTx) for patient's with inoperable stage III, based on the TNM classification according to the International Union against Cancer staging system for lung cancer (1987) non-small cell lung cancer (NSCLC). Methods. From January 1992 to December 1994,31 patients with cytologically or histologically confirmed stage III NSCLC were treated with RTx, to a total dose of 56–64 Gy, with concurrent daily oral administration of etoposide (25mg) and cisplatin (20mg) for 5 days during the third or fourth week from the start of RTx. The subcutaneous injection of 1 or 2 KE of OK-432, three times a week, for the duration of radiotherapy also started from the beginning of RTx. Results. The number of eligible patients was 29 (26 men and 3 women). Their mean age was 66 years (range, 55–77 years). Six patients had an Eastern Cooperative Oncology Group performance status (PS) of 0; 15, 1; 8; 2. Three were stage IIIA, and 26, stage ITIB. Histologically, 2 had adenocarcinoma, 23, squamous cell carcinoma, and 4, large cell carcinoma. In 27 of the 29 patients, the RTx schedule was completed. There were no treatment-related deaths. Grade 4 toxicity (according to World Health Organisation criteria) leukopenia (700/μl was observed in 1 patient. The response rate was 79% and the median survival was 17 months. Survival rates at 1, 2 and 3 years were 62%, 31%, and 21%, respectively. The local failure rate was 51%. Conclusion. The combination of cisplatin, etoposide, and K-432, given concurrently with conventional RTx is feasible and effective for inoperable stage III NSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539214
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...