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A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression (2002)

Murphy, L-A. ; Atherton, D.

Oxford, UK : Blackwell Science Ltd

British journal of dermatology 147 (2002), S. 0

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ISSN: 1365-2133

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary Background Atopic eczema is a chronic inflammatory skin disease, which in most children can be adequately controlled using topical therapy. However, in a small number of children it is necessary to use systemic treatments to gain an acceptable level of disease control. Objectives To evaluate azathioprine as a treatment for severe atopic eczema in children, and the value of pretreatment thiopurine methyltransferase (TPMT) levels in the identification of patients at high risk of myelosuppression. Methods Between January 1997 and May 2000, 91 children had erythrocyte TPMT assays with the intention of treating their atopic eczema with azathioprine. This study is based on retrospective examination of data taken from the hospital notes of these children, who had attended Great Ormond Street Hospital for Children and St John's Institute of Dermatology, London. Results The distribution of TPMT values corresponded closely to that previously described in adults. Forty-eight children were commenced on treatment with azathioprine. Twenty-eight had an excellent response to treatment, 13 had a good response and seven had a poor response. No patient developed neutropenia. Conclusions Azathioprine may prove a very valuable treatment for severe atopic eczema in children. We consider its short-term adverse effect profile in children with normal TPMT activity to have been entirely acceptable with our treatment protocol. As result, we now feel confident to initiate therapy at dose levels of 2·5–3·5 mg kg−1 in those with a normal TPMT level, and to reduce the frequency with which we undertake tests of bone marrow and liver function.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04922.x

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) (2002)

Chater, K. F. ; Cerdeño-Tárraga, A.-M. ; Challis, G. L. ; [et al.]

[s.l.] : Macmillian Magazines Ltd.

Nature 417 (2002), S. 141-147

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes ...