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  • 1
    Electronic Resource
    Electronic Resource
    Spin Density Distribution and Electronic Structure of Radical Anions of Ladder-type Oligorylenes (1994)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 116 (1994), S. 7341-7348 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00095a043
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  • 2
    Electronic Resource
    Electronic Resource
    Low-dose prednisolone/chlorambucil therapy in patients with severe membranous glomerulonephritis (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 277-282 
    Details
    ISSN: 1432-1440
    Keywords: Idiopathic membranous glomerulonephritis ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because of the high rate of spontaneous remission, treatment of membranous nephropathy with prednisolone and chlorambucil is still controversial. The aim of this study was to give this therapy only to those patients at risk of developing renal insufficiency and to test the efficacy of a low-dose therapeutic regimen. Seventeen patients with more than 10 g protein excretion per day (mean 16.9) and/or a deterioration in renal function (mean serum creatinine, 162 μmol/l) were included. Serum total protein, serum lipids, proteinuria, serum creatinine, and blood pressure were measured, along with the diuretic and antihypertensive medication. The observation time before the start of treatment was 27 ± 27 months. Steroids were given during months 1, 3, and 5 (methylprednisolone 3 × 500 mg intravenously) prednisolone 0.5 mg/kgBW daily per os for 1 week, then tapered by 0.1 mg/kg BW/week for 1 month. Chlorambucil was given during months 2, 4, and 6 at a dose of 0.12 mg/kgBW daily. At the end of treatment proteinuria had significantly decreased (mean of all patients, 7.8 ± 1.4 g/d) in all patients. Six months after the end of treatment proteinuria was significantly lower than at baseline in 14 of 17 patients. Hypoproteinemia and hyperlipidemia had improved; diuretic and antihypertensive medication were reduced. Elevated serum creatinine decreased in 7 of 9 patients (pretreatment, 227 ± 39 μmol/1; 6 months, 176 ± 28 μmol/l). Nonresponders with respect to serum creatinine responded with respect to proteinuria. Regarding adverse effects, two patients complained of dyspepsia while taking steroids; during chlorambucil treatment two patients experienced nausea and lack of appetite, and one developed leukopenia (1600/μl). Chlorambucil was stopped and cell counts normalized 2 weeks later. We conclude that low-dose prednisolone/chlorambucil is both safe and efficient in the majority of patients with severe membranous nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180040
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  • 3
    Electronic Resource
    Electronic Resource
    Role of cGMP and Ca2+ in Vertebrate Photoreceptor Excitation and Adaptation (1992)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 54 (1992), S. 153-176 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.54.030192.001101
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  • 4
    Electronic Resource
    Electronic Resource
    Alosetron repeat dose pharmacokinetics, effects on enzyme activities, and influence of demographic factors (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To assess the pharmacokinetics of alosetron, its effect on in vivo enzyme activities, and influence of demographic factors during repeated dosing.Methods : Thirty healthy men and women received 1 mg oral alosetron twice-daily for 29.5 days and a single oral dose of a metabolic probe cocktail before and on the last day of alosetron dosing. Serum alosetron concentrations were measured on days 1, 8, 15, 22 and 29. Probe-substrate and metabolite concentrations were measured after each cocktail dose.Results : Alosetron accumulation in serum was negligible. Exposure to alosetron did not alter probe-metabolite/substrate ratios associated with CYP2C19, 2E1, 2C9, or 3A4 activity, but modestly decreased those associated with CYP1A2 and N-acetyltransferase activity. Systemic exposure to alosetron was higher in women, positively correlated with age and body mass index, and negatively correlated with CYP1A2 activity. Incidence of constipation was higher in women, but not associated with alosetron concentration.Conclusions : Single dose data can reliably predict the pharmacokinetics of alosetron after repeated doses. Alosetron exhibits limited potential for inhibition of cytochrome P450-mediated metabolism. Interindividual differences in alosetron pharmacokinetics associated with demographic factors may be related to strong dependence on metabolism by CYP1A2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02031.x
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  • 5
    Electronic Resource
    Electronic Resource
    Penetration of ceftazidime into human pancreas (1993)
    Springer
    Infection 21 (1993), S. 229-234 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einsatz von Antibiotika bei schwerer akuter Pankreatitis (Stadium II und III) ist indiziert, da bakterielle Komplikationen häufigste Todesursache sind. Ceftazidim wurde hinsichtlich seiner Permeation in das Pankreassekret, in gesundes und chronisch entzündetes Pankreasgewebe sowie in nekrotische Areale bei schwerer Pankreatitis des Menschen untersucht. Im Pankreassekret fand sich 60 Minuten nach intravenöser Gabe von 35 mg/kg eine Spitzenkonzentration von 12,9±5,9 mg/l. Das sind 32% des korrespondierenden Serumspiegels. Die Gewebespiegel variierten, in Abhängigkeit vom Enzündungsstadium, zwischen 9 und 79% der jeweiligen Serumkonzentration. Auch in Pankreasnekrosen ließen sich nach fünftägiger Behandlung (3 × 2 g) Ceftazidimspiegel zwischen 1,8 und 6,9 mg/kg nachweisen. Somit sind in allen untersuchten Kompartimenten ausreichend hohe, antibakterielle Wirkspiegel nach Gabe von Ceftazidim in therapeutischer Dosierung nachweisbar, so daß sich aus pharmakokinetischer Sicht Ceftazidim als ein potentiell geeignetes Präparat bei Pankreatitis anbietet.
    Notes: Summary The use of antibiotics in patients with severe acute pancreatitis (stage II and III) is indicated since bacterial complications are the most common cause of death in these patients. In the present study the penetration of ceftazidime into pancreatic juice, into healthy and chronically inflamed pancreatic tissue as well as into necrotic regions in cases of severe acute pancreatitis was investigated. A peak concentration of 12.9±5.9 mg/l was found 60 min after intravenous administration of 35 mg/kg of the drug, which is 32% of the corresponding serum levels. Pancreatic tissue concentrations varied between 9 and 79% of the corresponding serum levels, depending on the stage of inflammation. After five days of antibiotic treatment with doses of 2 g t.i.d., concentrations between 1.8 and 6.9 mg/kg were detected even in pancreatic necroses. This suggests that sufficient antibacterial levels of ceftazidime were present in all pancreatic compartments analyzed following administration of common therapeutic dosages. Therefore, from a pharmacokinetic point of view, ceftazidime could be a potentially effective drug for the treatment of pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728896
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  • 6
    Electronic Resource
    Electronic Resource
    Bis(N-piperidyldithiocarbamato)copper(III) hexafluorophosphate: an unexpected product from the disproportionation of 1,12-bis(N-piperidyl)-2,5,8,11-tetrathiadodeca-1,12-dithionato-CuI.PF6 (1991)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 26-29 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270190007168
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of the SOFA score: a single-center experience of a medical intensive care unit in 303 consecutive patients with predominantly cardiovascular disorders (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1037-1045 
    Details
    ISSN: 1432-1238
    Keywords: Key words Severity of illness index ; Multiple organ failure ; Critically ill ; Morbidity ; Organ failure ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score, the total maximum SOFA (TMS) score, and a derived variable, the ΔSOFA (TMS score minus total SOFA score on day 1) in medical, cardiovascular patients as a means for describing the incidence and severity of organ dysfunction and the prognostic value regarding outcome. Design: Prospective, clinical study. Setting: Medical intensive care unit in a university hospital. Patients: A total of 303 consecutive patients were included (216 men, 87 women; mean age 62 ± 12.6 years; SAPS II 26.2 ± 12.7). They were evaluated 24 h after admission and thereafter every 24 h until ICU discharge or death between November 1997 and March 1998. Readmissions and patients with an ICU stay shorter than 12 h were excluded. Main outcome measure: Survival status at hospital discharge, incidence of organ dysfunction/failure. Interventions: Collection of clinical and demographic data and raw data for the computation of the SOFA score every 24 h until ICU discharge. Measurements and main results: Length of ICU stay was 3.7 ± 4.7 days. ICU mortality was 8.3 % and hospital mortality 14.5 %. Nonsurvivors had a higher total SOFA score on day 1 (5.9 ± 3.7 vs. 1.9 ± 2.3, p 〈 0.001) and thereafter until day 8. High SOFA scores for any organ system and increasing number of organ failures (SOFA score ≥ 3) were associated with increased mortality. Cardiovascular and neurological systems (day 1) were related to outcome and cardiovascular and respiratory systems, and admission from another ICU to length of ICU stay. TMS score was higher in nonsurvivors (1.76 ± 2.55 vs. 0.58 ± 1.39, p 〈 0.01), and ΔSOFA/total SOFA on day 1 was independently related to outcome. The area under the receiver-operating characteristic curve was 0.86 for TMS, 0.82 for SOFA on day 1, and 0.77 for SAPS II. Conclusions: The SOFA, TMS, and ΔSOFA scores provide the clinician with important information on degree and progression of organ dysfunction in medical, cardiovascular patients. On day 1 both SOFA score and TMS score had a better prognostic value than SAPS II score. The model is closely related to outcome and identifies patients who are at increased risk for prolonged ICU stay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051316
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  • 8
    Electronic Resource
    Electronic Resource
    Ein neues resorbierbares Knochen-Knorpel-Ersatztransplantat (2000)
    Springer
    Der Orthopäde 29 (2000), S. 151-157 
    Details
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Bioimplantat • Biomechanik •¶Knorpeldefekt • Knorpelregeneration •¶Mesenchymale Zelldifferenzierung ; Key words Bioimplant • Biomechanics • Cartilage ¶defect • Cartilage repair • Mesenchymal cell differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Hyaline cartilage is thought to be unable to regenerate. All efforts so far – including autologous chondrocyte cell transplantation – to reconstruct cartilage defects in joints have not been totally convincing. However, mesenchymal cells are able to differentiate into chondrocytes under mechanical pressure conditions. In this study, an open porous resorbable two-layer “bioimplant” was constructed in which mechanical pressure was exerted onto mesenchymal cells when migrated into the open porous structure of the bioimplant. Differentiation of the cells into chondrocytes was thus induced. The bioimplants were implanted into the medial condyles of nine rabbits and left in place for eight or twelve weeks, respectively. In seven of these cases, cartilage formation was found, in contrary to the controls in which only connective tissue and bone had grown into the empty holes. The new bioimplants have proven their effectiveness in cartilage defect repair and might evolve in the future as a new alternative treatment of full thickness defects of joint surfaces.
    Notes: Zusammenfassung Gelenkknorpel gilt in der Regel als nicht regenerationsfähig. Bis jetzt durchgeführte Versuche zur Wiederherstellung des Gelenkknorpels, inklusive der Knorpelzelltransplantation, zeigten wenig erfolgversprechende Ergebnisse. Jedoch gibt es Hinweise, dass unter Druckbelastung mesenchymale Stammzellen sich in Knorpelzellen differenzieren können. In der vorliegenden Studie wurde ein offenporiges resorbierbares, zweischichtiges „Bioimplantat“ konstruiert, das nach Implantation in einen Knochen-Knorpel-Defekt die physiologischen Druckverhältnisse nachahmt und so eine Differenzierung von mesenchymalen Stammzellen zu hyalinem Knorpel ermöglicht. An 9 Kaninchen wurde dieses Bioimplantat an Knochenknorpeldefekten des Femurkondylus über 2 verschiedene Zeiträume erprobt und mit Leerlochversuchen verglichen. Durch die Bioimplantate gelang es im Gegensatz zu den Leerlochversuchen in 7 von 9 Fällen Bereiche mit hyalinartigem Knorpel zu induzieren. Die Methode scheint einen neuen erfolgsversprechenden Ansatz zur Reparation von Knorpeldefekten darzustellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003710
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of antihypertensive therapy on renal function (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. S120 
    Details
    ISSN: 1432-1440
    Keywords: Hypertension ; Kidney ; Antihypertensive drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antihypertensive therapy influences kidney function by different mechanisms depending on the mode of action of the drug used. The GFR is improved by calcium entry blockers and ACE inhibitors, unaffected by vasodilators, α-blockers and centrally acting sympatholytics and impaired by β-blockers. The same is true for renal blood flow and is due to changes of renal vascular resistance. Renal sodium excretion is impaired mostly by vasodilators, by α-blockers, sympatholytics and β-blockers; in contrast, calcium entry blockers and ACE inhibitors acutely induce natriuresis. The RAAS is stimulated by vasodilators, unaffected by α-blockers and sympatholytics and suppressed by β-blockers. Plasma catecholamines are stimulated by vasodilators and suppressed by centrally acting sympatholytics and unaffected by the others. Induction of acute renal functional impairment is reported for ACE inhibitors under conditions of compromised renal perfusion pressure such as in renal artery stenosis. These data from the literature reviewed are supported by our own experimental data on sodium balance under different drugs and micropuncture data in experimental renal artery stenosis. To achieve effective antihypertensive treatment with a low profile of side effects, careful monitoring of renal function seems to be mandatory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207622
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  • 10
    Electronic Resource
    Electronic Resource
    Das Verhalten der Herzfrequenz unter pulsatiler Betamimetika- Applikation (Bolustokolyse) (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 1438-1439 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02266466
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