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  • 2000-2004  (1)
  • 1985-1989  (1)
  • 1
    ISSN: 1437-2320
    Keywords: Key words Focal cerebral ischemia ; Programmed neuronal death ; Nimodipine ; Mannitol ; Cerebroprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study was conducted to evaluate the effects of nimodipine and mannitol on infarct size and on the amount of apoptosis after transient focal cerebral ischemia. Focal cerebral ischemia was induced in male Sprague-Dawley rats (weight 300–380 g) by transient occlusion of the right middle cerebral artery (MCAO) using an intraluminal thread model. All animals underwent ischemia for 2 h, followed by 24 h of reperfusion. Group I (n=16) was untreated. Group II (n=16) received 15% mannitol (1 g/kg as bolus) and group III (n=9) received 15 µg/kg/h nimodipine intravenously beginning 15 min prior to MCAO. Twenty-four hours after reperfusion, the brain was taken and sectioned in coronal slices. The slices were stained with H&E and with the transferase dUTP nick-end labeling (TUNEL) technique. Histopathological analysis revealed a significant (P〈0.05) decrease in infarct size in the striatum with both drugs: mannitol (group II) 25.4±5.9% and nimodipine (group III) 21.5±11.0% versus control (group I) 34.9±7.0% and in the cortex 2.7±2.0% (group II) and 6.3±2.4% (group III) versus control 14.4±9.0% (group I). The number of apoptotic cells was statistically lower in the therapy groups (group III 9.6, group II 25.8) versus control (group I 57.9) (Mann-Whitney-Wilcoxon U-test Z〉1.96, P〈0.05). This study indicates that mannitol and nimodipine provide neuroprotection by preventing both the necrotic and apoptotic components of cell death after transient focal cerebral ischemia and may be effective as neuroprotective drugs for cerebrovascular surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 74 (1988), S. 171-184 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary To study how the rate of deformation effects forming rate sensitive materials, the Bodner-Partom elastic-viscoplastic constitutive law is incorporated into a finite element program. This law postulates both elastic and plastic components of deformation at any stress level. The stress is a Hookean function of the elastic strain, while the plastic deformation rate is a function of the deviatoric stress and an internal state variable defining the load history. The finite element derivation adopts the small strain assumption with updated coordinates. The equilibrium rate equation is formulated using total velocities with the nonlinearities incorporated into an equivalent plastic load vector depending upon the current stress. The resulting equation explicitly includes time and is a true rate equation. The program calculates the current stress field using the incremental equilibrium equation. An iterative technique is used to ensure that the assumed current load rate used to calculate the current stress field is correct. Convergence of the iteration procedure needs only be monitored at the velocity specified nodes. To demonstrate the applicability of this method, two plane strain problems, a tensile bar and strip rolling, with rate sensitive materials are investigated.
    Type of Medium: Electronic Resource
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