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  • 1
    Electronic Resource
    Electronic Resource
    Delayed cutaneous hypersensitivity in children with severe multiple handicaps treated with phenytoin (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 273-278 
    Details
    ISSN: 1432-1076
    Keywords: Severe multiple handicaps ; Cutaneous hypersensitivity ; Phenytoin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral lymphocyte counts, T-cell and B-cell populations, DNCB skin reactions, Mantoux reactions, mitogenic transformation using PHA, and determination of serum phenytoin concentration were carried out in 45 children with severe handicaps. Twenty two of these patients were receiving phenytoin treatment. When compared with control subjects, the skin reactions were significantly depressed in the handicapped children, amongst whom those treated with phenytoin had more impaired reactions than those who were untreated. No significant relationship between the results of the skin reactions and the other parameters was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441358
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  • 2
    Electronic Resource
    Electronic Resource
    Simulation studies of heavy ion heating by current-driven instabilities (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 4882-4888 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Nonlinear evolution of current-driven instabilities and associated energy transport among different particle species are studied by means of a two-dimensional, electrostatic, particle simulation code with full ion and electron dynamics. The plasma is assumed to consist of hydrogen (H) and helium (He) ions and electrons with the electron temperature larger than the ion temperatures; the electrons drift along a uniform magnetic field with an initial speed equal to the thermal speed. Then, simulations show that after the development of ion acoustic waves and fundamental H cyclotron waves, second harmonic waves are destabilized due to the change in the electron velocity distribution function parallel to the magnetic field, fe(v(parallel)). Even though the linear theory based on the initial conditions predicts that the second harmonics are only marginally unstable, they eventually grow to the largest amplitudes and heat He ions more significantly than H ions. The instabilities of these three kinds of modes with different phase velocities give rise to flattening of fe(v(parallel)) over a region larger than the thermal speed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1321017
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Age changes in the perception of comfortable mandibular occlusal positions (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 5 (1978), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been shown that a zone of comfort in maxillo-mandibular relationships in edentulous subjects can be identified with some precision. Whilst the neurophysiological mechanism involved has not been explained fully, the phenomenon is influenced by starting position and by fatigue. This experiment was set up to test the hypothesis that age is another significant factor in perception of the comfortable zone.A group of seventeen subjects with a mean age of 62 years and an equivalent younger group, the mean age of which was 28 years, were tested with Timmer screw jacks applied using the central approach to record the upper and lower limits of the zone fifteen times in succession for each subject.A linear statistical model was used to analyse the data from upper and lower borders separately. The results showed that the effect of making successive adjustments, whilst not significant statistically in the young group, was significant in the more elderly. Regression lines from the young group data were horizontal signifying the high degree of accuracy with which their perceptual mechanisms worked: the upwards inclination of those from the more elderly was interpreted as showing that initial appreciations were subjected to constant correction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1978.tb01255.x
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  • 4
    Electronic Resource
    Electronic Resource
    Does a temperature gradient exist across the mucogingival junction? (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 5 (1978), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: On the assumption that the colour difference between attached gingiva and alveolar mucosa is accompanied by a temperature difference, twenty subjects with a high standard of oral health were studied. Five points on either side of the mucogingival junction were examined by means of a thermocouple probe. A mean difference amounting to about 2/3°C was found between the surface temperatures of the two structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1978.tb00394.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mucosal temperature rises following long-term use of full dentures (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 6 (1979), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mucosal temperatures were studied in twenty-two subjects, who had worn full upper and lower dentures for at least 5 years. By comparing with a group of twenty-two fully dentate subjects, it was found that in the denture wearers, temperatures were increased significantly in the lower jaw, but not in the upper jaw.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1979.tb01505.x
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  • 6
    Electronic Resource
    Electronic Resource
    p53-dependent regulation of heat shock protein 72 (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background p53 is a key regulator of the cellular stress response. p53 modulates the transcription of several genes. Objectives To examine the influence of p53 on expression of heat shock protein 72 (HSP72). Methods Two model systems were used. (i) HSP72 expression was studied by Western blot on extracts from p53-proficient or p53-deficient primary mouse keratinocytes, and (ii) archival human anogenital skin from fibroepithelial polyps, human papillomavirus (HPV) 16/18-associated lesions or squamous cell carcinomas (SCCs) was subjected to immunostaining for HSP72. Results Basal HSP72 expression was higher in keratinocytes from p53-deficient than from p53-proficient mice. Immunostaining for HSP72 was higher in HPV 16/18 lesions and SCCs, which have reduced p53 protein. Conclusions p53 status may influence the basal level of HSP72.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04721.x
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  • 7
    Electronic Resource
    Electronic Resource
    Compound heterozygous group A xeroderma pigmentosum patient with a novel mutation and an inherited reciprocal translocation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The severity of neurological abnormalities in Japanese group A xeroderma pigmentosum (XP-A) patients correlates with the sites of non-sense mutation in the XP-A gene. We describe a patient who presented with a more severe photosensitivity and neurological abnormality than those in typical Japanese XP-A patients with a splicing mutation in intron 3. The patient was compound heterozygous for the splicing mutation in intron 3, which resulted in formation of a non-sense codon in exon 4, and a novel non-sense mutation at codon 208 in exon 5, a C to T transition creating a stop codon TAG. Although the combination of these mutations might have been thought to cause only mild neurological signs, the longer truncated XP-A proteins than those of typical XP-A patients may have resulted in severe neurological symptoms. This phenomenon may be explained by a translocation of chromosome (1;10)(q25·3;q22·3) inherited from his father.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03611.x
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  • 8
    Electronic Resource
    Electronic Resource
    Oral temperatures in young and old people (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 6 (1979), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oral temperatures were measured in ten young females and ten young males, and compared to oral temperatures measured in ten elderly females and ten elderly males. Each subject had a complete natural dentition. When analysed by sex, it was found that the temperatures in elderly males were lower than in young males (P 〈 0.001), while temperatures in young and elderly females did not differ. Concerning sublingual temperatures, a difference of approximately one-third of a degree centigrade was demonstrated between the two age groups (P 〈 0.005).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1979.tb01276.x
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  • 9
    Electronic Resource
    Electronic Resource
    Crevicular temperature rises stimulated by plaque formation (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 6 (1979), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In nineteen subjects, temperatures were recorded thermo-electrically in the vestibular and proximal crevices of fifty-nine teeth. It was found that the formation of a new plaque was followed by a rise in crevicular temperature. In addition, it was found that the normal as well as the abnormal crevicular temperatures were higher in the mandible than in the maxillae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1979.tb01500.x
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  • 10
    Electronic Resource
    Electronic Resource
    Merkel-like cells in Malassez epithelium in the periodontal ligament of cats: an immunohistochemical, confocal-laser scanning and immuno electron-microscopic investigation (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of periodontal research 37 (2002), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cellular heterogeneity of Malassez epithelium (ME) residing in the periodontal ligament has recently been reported, and the presence and coexistence of the neuropeptides calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP) in single cells in ME has been shown (1). However, the identity of these neuroendocrine cells has so far not been verified. This study was undertaken in order to elucidate the identity of the neuroendocrine cells in ME by means of transmission electron microscopy, confocal scanning microscopy and immunohistochemistry using antibodies to protein gene product (PGP) 9.5 and cytokeratin 20 (CK). Gingival tissue was included in the study as a positive control for identification of Merkel-like cells in oral epithelium. CK 20 immunopositive cells were present in both Malassez epithelium and in basal cell layers of gingival epithelium showing a distribution consistent with PGP 9.5 labelled cells in both epithelia. The results from PGP 9.5 immuno electron microscopy clearly evidenced the presence of single, intensely labelled cells and some nerve fibres invested between the Malassez epithelial cells. The conformity of the immunopositive cells in Malassez and gingival epithelium verified by double immunolabelling with PGP 9.5 and CK 20, indicates that the labelled neuroendocrine cells are identical in ME and in gingival epithelium. This demonstrates that Malassez epithelium not only exhibits neuroendocrine cells, but additionally that the neuroendocrine cells represent Merkel-like cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0765.2002.01374.x
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