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  • 2000-2004  (7)
  • 1970-1974  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Nasal air sampling used for the assessment of occupational allergen exposure and the efficacy of respiratory protection (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Occupational exposure to rodent allergens may cause laboratory animal allergy. Personal exposure to occupational allergens is measured by collecting airborne dust on filters using person-carried pumps. This technique cannot be used to evaluate personal protective respiratory equipment. Recently developed intranasal air samplers collect inhaled particles by impaction on adhesive strips within the samplers.Objective The aims were to compare rodent aeroallergen exposure assessment using nasal air samplers with personal air sampling, and to evaluate the efficacy of using respiratory protection during rodent work using nasal air samplers.Methods Aeroallergen exposure was assessed during rodent work using both nasal air samplers and personal air samplers. The efficacy of respiratory protection (P2 facemasks and fresh-air helmets) was studied in subject pairs working side by side, one person with protection, the other without. Right nostril samples were laminated with protein-binding membrane and immunostained for rat urinary allergen-containing particles. Left nostril samples and air samples were eluted in buffer and analysed in amplified ELISAs for rat (RUA) and mouse (MUA) urinary allergen content (detection limit 10 pg/mL). Allergen collection efficacy of the nasal air samplers was tested at high and low exposure levels and at different flow rates using static sampling.Results P2 facemasks decreased the amount of inhaled allergen by about 90%, and very little allergen was inhaled using fresh-air helmets. Allergen levels in air and nasal samples correlated well (rs was about 0.8 for both RUA and MUA). The number of RUA-positive particles and nasal allergen levels measured in ELISA also correlated significantly (rs = 0.8). Collection efficacy of the nasal air sampler was better during high exposure (cleaning cages, median 73% of allergenic particles collected), than during low exposure (undisturbed room, 49% of particles).Conclusion Nasal air sampling is a relevant and sensitive complement to personal air sampling and enables evaluation of personal respiratory protection equipment. Use of P2 facemasks and fresh-air helmets may substantially reduce occupational exposure to inhaled allergens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01545.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of four allergen-sampling methods in conventional and allergy prevention classrooms (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Several allergen-sampling methods are used to assess level of personal or indirect exposure to cat in homes, schools and other public buildings and working environments.Objective To compare four different allergen-sampling methods (dust collectors, Petri dishes, person-carried pumps and intranasal samplers) by simultaneous sampling in classrooms and to compare the cat allergen levels between conventional classrooms and allergy prevention classrooms. Another aim was to relate the results to self-reported frequency of allergy and asthma symptoms among the children, to their perception of the school environment.Methods Among all compulsory schools (n = 257) in the Stockholm suburban area, 35 classrooms (five with implemented allergy prevention measures, seven with additional cleaning and 23 with normal cleaning routines) were chosen for allergen-sampling. Dust collectors (two models), Petri dishes, person-carried pumps and intranasal samplers were used simultaneously. All children (n = 829) received a self-administered questionnaire which included questions about home and school environment, allergic disease, asthma symptoms and pet contact.Results The correlation between sampling methods was generally poor. Furthermore, there was no significant difference in allergen levels between allergy prevention and allergen avoidance classes compared to conventional classes. Median levels were generally, but not significantly, lower in classes with few cat owners, compared to classes with many cat owners. Children in allergy prevention classes were more satisfied with the indoor air quality and cleaning than children attending classes with fewer or no allergy prevention measures (P 〈 0.0001). Nine per cent of all children reported allergic symptoms while at school.Conclusion The lack of correlation between sampling methods used simultaneously demonstrates the difficulty in assessing allergen levels in schools and similar environments. The implemented intervention measures (allergy prevention/allergen avoidance) did not influence cat allergen levels at school.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01553.x
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  • 3
    Electronic Resource
    Electronic Resource
    Phagocyte Activation by Trp–Lys–Tyr–Met–Val–Met, Acting through FPRL1/LXA4R, is not Affected by Lipoxin A4 (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lipoxin A4 (LXA4) has been shown to bind to the leucocyte formyl peptide receptor (FPR) homologue, FPRL1, without triggering the biological activities induced by other FPRL1 agonists. We investigated the direct effect of LXA4 as well as the effect on agonist-induced biological responses using transfected HL-60 cells expressing FPR, FPRL1 or FPRL2. LXA4 neither induced an intracellular rise in calcium in these transfectants nor affected the response induced by the peptide Trp–Lys–Tyr–Met–Val–Met (WKYMVM), an agonist that activates cells through FPRL1 and -2. Both agonists induced Erk-2 activation; however, the eicosanoid-induced activity was independent of FPRL1 and FPRL2. Moreover, LXA4 was unable to trigger neutrophil upregulation of complement receptor 3 and respiratory burst, and it had no effect on the responses induced by triggering with WKYMVM. We conclude that LXA4 is unable to affect the WKYMVM-induced signalling through FPRL1 and suggest that it acts through a receptor different from FPRL1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01149.x
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  • 4
    Electronic Resource
    Electronic Resource
    Allergen avoidance does not alter airborne cat allergen levels in classrooms (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Some schools in Sweden offer allergen avoidance classrooms for allergic children with severe asthma. However, the measures commonly used to achieve a reduction in allergen levels have not been properly evaluated. The aim of the present prospective study was to study whether the levels of airborne cat allergen are altered after introducing feasible intervention measures in classrooms, without interfering with peoples’ freedom of choice regarding pet ownership.Methods:  Twenty-five classes, including five established allergy prevention classrooms participated in the study during a school year. After one term, six classes underwent a number of intervention measures recommended by the Swedish National Institute of Public Health. Curtains, upholstery and plants were removed, bookshelves were replaced with cupboards and regular cleaning was increased. Airborne dust was collected weekly (32 weeks) using duplicate Petri dishes (n = 1574) and on six occasions using two personal air samplers in each class (n = 264).Results:  Airborne cat allergen levels were showing a similar variability throughout the whole study in all classes. Despite extensive measures in order to reduce allergen exposure, cat allergen levels were unaltered in the six classes after intervention. Allergen levels were not significantly lower in the established allergy prevention classes, compared with the other classes. Cat allergen levels differed, however, significantly between classes with few and many cat owners (P 〈 0.05).Conclusions:  We conclude that the recommended allergen avoidance measures used in this study did not reduce airborne cat allergen. It seems plausible that measures that fail to reduce allergen levels also fail to influence health status in allergic children but this remains to be shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00519.x
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  • 5
    Electronic Resource
    Electronic Resource
    Bet v 1 homologues in strawberry identified as IgE-binding proteins and presumptive allergens (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  No strawberry allergen has so far been identified and characterized.Methods:  Serum samples were collected from patients with a suggestive case history of adverse reactions to strawberry and other fruits. Extracts from fresh and frozen strawberries were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), Western blotting and mass spectrometry. Patient blood samples were analysed for inhibition of IgE binding and basophil degranulation.Results:  Several IgE-binding proteins could be detected. In more than half of the patient sera, a 20/18-kDa doublet band was observed in Western blotting. These two bands were excised and analysed by mass spectrometry showing the presence of proteins belonging to the Bet v 1 family of allergens. Inhibition of the IgE binding to the 20/18-kDa doublet was obtained by addition of two recombinantly expressed allergens belonging to the Bet v 1 family (Bet v 1 and Mal d 1) and strawberry protein extract. In a cell-based assay of patient blood samples, basophil degranulation could be induced by strawberry protein extract and by Bet v 1 and Mal d 1.Conclusions:  We conclude that strawberry homologues to Bet v 1 may be allergens of importance for adverse reactions to strawberry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00585.x
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of Petri dish sampling for assessment of cat allergen in airborne dust (2002)
    Oxford, UK : Blackwell Science, Ltd
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Dust reservoir sampling is the most commonly used method for assessment of indirect allergen exposure. Because assessment of personal exposure using person-carried pumps is time-consuming and expensive we evaluated the Petri dish sampling method for measurement of airborne cat allergen in classrooms. Methods: Petri dish sampling was evaluated in three study parts. Part I: by comparison between Petri dish sampling and personal air sampling in 44 classrooms with many (≥ 20%) and few (≤ 10%) cat owners and by additional Petri dish sampling in 40 pet-free homes. Part II: by sampling with duplicate Petri dishes in 28 classrooms. Part III: by sampling in three classrooms at four sampling heights during different sampling times. All samples were analyzed for cat allergen (Fel d 1) content with a monoclonal antibody two-site ELISA (enzyme linked immunosorbent assay), using signal amplification when necessary. Results: There was a significant correlation between Petri dish sampling and personal air sampling (r = 0.66; P 〈 0.0001). Levels were five-fold higher in classes with many cat owners than in classes with few cat owners, regardless of method. A corresponding difference was found in the homes. Duplicate sample values were in fair agreement (Bland-Altman test) and were correlated (r = 0.77; P 〈 0.0001). Cumulative levels collected weekly in one Petri dish were lower than using five daily Petri dishes, regardless of sampling height. Conclusions: Petri dish sampling can be useful as an alternative method to personal air sampling of airborne allergens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2002.1s3297.x
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  • 7
    Electronic Resource
    Electronic Resource
    Working with male rodents may increase risk of all_ergy to laboratory animals (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Our aim was to study the risk of laboratory animal all_ergy (LAA) among research staff working in laboratories separate from the animal confinement area. The roles of atopy and exposure intensity in LAA were studied with special regard to exposure to male rodents, who excrete higher levels of urinary all_ergens than female rodents. Methods: Eighty rodent-exposed subjects gave blood samples for the analysis of total IgE, Phadiatop, and specific IgE against rat (RUA) and mouse urinary all_ergens (MUA), and answered questionnaires. Air samples were collected for RUA and MUA aeroall_ergen measurement in both laboratories and animal confinement facilities. Results: Twenty percent of the subjects had IgE 〉0.35 kU/l to RUA and/or MUA, and 32% had experienced animal work-related symptoms, although 90% of aeroall_ergen samples from the research department laboratories were below the detection limit (〈0.26 ng RUA per m3 and 〈0.8 ng MUA per m3). Atopy (positive Phadiatop), total IgE 〉100 kU/l, other all_ergies (especiall_y to other animals), or more than 4 years of exposure significantly increased laboratory animal sensitization and symptoms. Working with mainly male rodents gave odds ratios (95% CI) of 3.8 (0.97–15) for sensitization and 4.4 (1.4–14) for symptoms. Subjects with both exposure to mainly male rodents and atopy or elevated total IgE had a 10-fold higher frequency of sensitization than exposed subjects with neither risk factor. Conclusions: A majority of subjects with a combination of exposure to mainly male rodents and atopy or elevated total IgE developed sensitization to and symptoms from laboratory animals. Current low exposure seems to maintain the presence of specific IgE. Further measures must be undertaken to provide a safe workplace for laboratory animal workers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00899.x
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  • 8
    Electronic Resource
    Electronic Resource
    Magnetic-field-induced semiconductor-semimetal transition in Bi-Sb alloys (1970)
    Springer
    Journal of low temperature physics 3 (1970), S. 147-174 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Accurate and detailed measurements of the temperature dependence of the longitudinal magnetoresistance of single-crystal Bi-Sb alloys have been made, with static magnetic fields in the range 0–100 kG oriented parallel to the trigonal axis. Alloy concentrations were in the range 8–12 at.% Sb, and temperatures in the range 1–35 K. At very high fields the resistance increases with increasing temperature in a metallic manner with “ideal” and “residual” components, in contrast to the semiconductor behavior observed at zero field or low fields. For the high-field semimetal regime the electrical resistance behaves in a simple manner similar to a metal in zero field, in contrast to the complicated magnetoresistance phenomena for metals in low fields. This behavior can be understood in terms of a simple quasi-one-dimensional extreme-quantum-limit regime. The magnetic-field-induced semiconductor-semimetal transition is associated with an energy gap and changes of the energy-band structure which are of order 1 meV. Thermal activation energies for electrical conduction manifest this gap only at temperatures below approximately 20 K. Activation energies an order of magnitude larger which have been measured at considerably higher temperatures are apparently the direct gap at theL-point in the Brillouin zone and are not directly connected with the semiconductor-semimetal transition. Our results indicate that the zero-field indirectL-T energy gap increases from zero somewhere near 7–8 at. % Sb to values only as large as approximately 1.5 meV at 12 at. % Sb. At the magnetic-field induced transition there occurs evidence of an intermediate “excitonic insulator” phase, a resistance minimum below 10 K reminiscent of the Kondo alloy behavior. This anomalous regime is a property of the semiconductor-to-semimetal transition and cannot be associated with the well-known temperature and magnetic-field “freeze-out” of charge carriers in extrinsic semiconductors, or with magnetic ordering of the Kondo type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00628324
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  • 9
    Electronic Resource
    Electronic Resource
    A simple calculation model with great versatility for interelement effects in steel by X-ray fluorescence analysis (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 2 (1973), S. 75-83 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Demands of more rapid and accurate answers for the steel plant made it necessary to develop a computerized system for calculation and control of the analysis performed on X-ray fluorescence and optical emission spectrometers. The interelement effects which occur in X-ray fluorescence analysis are briefly described and the evolution of a model for these corrections is examined. This model includes corrections for absorption and secondary fluorescence as well as overlapping, dead time effects, etc. which are based on simplified theoretical formulae and can be used for a broad field of applications. The parameters in the model have been determined empirically by measuring a wide range of binary alloys. The interelement effects in optical emission analysis are calculated according to a simple emprical formula. The mathematical models have been fitted to a computer (Datasystem Trask P100) which also controls the two separate spectrometers. Examples are given of routine analysis performed by this model on bulk solids of steels and fused glassy borates of sinters, slags and hard metals. Its chief advantage is that the usual requirement for a great number of standards is eliminated.
    Additional Material: 9 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300020207
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