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  • 1
    Electronic Resource
    Electronic Resource
    Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation (2000)
    Springer
    Journal of neurology 247 (2000), S. 376-382 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Haemopoietic stem cell transplantation ; Consensus guidelines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent reports suggest the possible beneficial effects of haemopoietic stem cell transplantation (HSCT) in autoimmune diseases such as multiple sclerosis (MS). The definition of the risk/benefit ratio for such a treatment is perceived as a major issue for the neurological community worldwide. The First Consensus Conference on Bone Marrow Transplantation in Patients with Multiple Sclerosis was held in Milan, Italy on 21 February 1998. Participants from 16 European, North American, and South American countries discussed the guidelines form performing HSCT in MS. This conference was organized in order to : (a) define criteria for patient selection; (b) define transplantation procedures to maximize efficacy of the treatment and minimize its toxicity; (c) standardize patient outcome evaluation; and (d) establish an international working group to evaluate the efficacy and safety of HSCT in MS and to study the immunological changes related to HSCT in MS patients. During the meeting in Milan agreement was reached on: (a) the preparation and distribution of a consensus report on HSCT in MS and (b) the design of an open trial for an initial assessment of the safety and efficacy of HSCT in MS. The consensus reached during the meeting and the design of the clinical trial are summarized in this contribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050605
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  • 2
    Electronic Resource
    Electronic Resource
    The use of magnetic resonance imaging in multiple sclerosis treatment trials: power calculations for annual lesion load measurement (2000)
    Springer
    Journal of neurology 247 (2000), S. 34-40 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Treatment trial ; Power calculations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phase III definitive treatment trials of new multiple sclerosis (MS) therapies now routinely incorporate an annual magnetic resonance imaging protocol, with change in T2-weighted brain lesion load providing an important outcome measure. To date the accepted strategy has been to perform a core imaging protocol on all patients in such studies. The aim of this study was to provide power calculations based on this MRI endpoint. Serial MRI data from 128 patients with either relapsing remitting (RR) or secondary progressive (SP) MS were used to calculate sample size requirements using a repeated measures analysis of variance design. We provide sample size calculations based on various follow-up intervals and effect sizes. Sample sizes for the SPMS cohort were substantially larger than for the RRMS group, reflecting the greater variance in lesion load changes between patients in the SPMS group. With a follow-up of 3 years, we estimate that only 12 and 33 patients per arm are needed to show stabilisation of MRI lesion load in the RRMS and SPMS groups, respectively. Our results suggest that ongoing phase III treatment trials are more than adequately powered to detect even subtle treatment effects, and indicate that incorporating measurements from longer follow-up durations increases power substantially. We conclude that an annual imaging protocol provides a robust and powerful tool for assessing effects on the radiological appearance of the disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The contribution of fast-FLAIR MRI for lesion detection in the brain of patients with systemic autoimmune diseases (2000)
    Springer
    Journal of neurology 247 (2000), S. 29-33 
    Details
    ISSN: 1432-1459
    Keywords: Key words Magnetic resonance imaging ; Turbo spin echo ; Fast fluid attenuated inversion recovery ; Systemic autoimmune diseases ; Brain lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fast fluid-attenuated inversion recovery (fFLAIR) is more sensitive that conventional or fast spin echo T2-weighted magnetic resonance imaging (MRI) for detecting lesions in the brain of patients with ischemic, inflammatory, or demyelinating diseases of the CNS. We ¶investigated whether the use of fFLAIR also increases the sensitivity of brain MRI assessment in patients with systemic autoimmune disorders. Turbo spin echo (TSE) dual-echo and fFLAIR scans of the brain were obtained from patients affected by systemic lupus erythematosus (SLE) with (NSLE, n = 9) and without clinical CNS involvement (n = 15), Behçet disease (n = 5), Wegener granulomatosis (n = 9), and antiphospholipid antibody syndrome (n = 6). Brain hyperintense lesions were counted and classified according to their size and their location by two observers by consensual agreement. The total lesion volume was measured using a semiautomated technique for lesion segmentation on both TSE and fFLAIR scans. The imaging modalities showed brain hyperintense lesions in all 9 SLE patients with CNS involvement, 5 of 15 SLE patients without CNS involvement, 5 of 9 patients with Wegener granulomatosis, 1 of 5 with Behçet disease, and 3 of 6 with antiphospholipid antibody syndrome. ¶A total of 342 lesions were seen on both sequences; 88 were seen only on TSE and 54 only on fFLAIR scans. The average number of brain lesions per scan was higher on TSE than on fFLAIR, since significantly more discrete (P 〈 0.002) and small (P = 0.004) lesions were seen on TSE than on fFLAIR. The median total lesion volume, however, was similar on TSE and fFLAIR. Our study indicates that the use of fFLAIR does not improve the sensitivity of fast dual-echo MRI for detecting brain abnormalities in patients with systemic autoimmune disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050006
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  • 4
    Electronic Resource
    Electronic Resource
    Temperature dependent local Cu-O displacements from underdoped to overdoped La-Sr-Cu-O superconductor (2003)
    Springer
    The European physical journal 36 (2003), S. 75-80 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We have studied doping evolution of the temperature dependent local Cu-O displacements in the La2-x Sr x CuO4 superconductor by polarized Cu K-edge extended X-ray absorption fine structure (EXAFS) measurements. While temperature dependent Debye-Waller factor of the Cu-O bonds, measuring the local Cu-O displacements, shows an anomalous increase at low temperature for the underdoped single crystals, we do not find such a dependence for the case of the overdoped system. The results, which are discussed in the light of recent angle resolved photoemission measurements, provide an evidence for some important correlation between the doping dependent electron-lattice interaction, the charge inhomogeneities and the local Cu-O displacements in the copper oxide superconductors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2003-00318-9
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  • 5
    Electronic Resource
    Electronic Resource
    The role of magnetization transfer and diffusion-weighted MRI in the understanding of multiple sclerosis evolution (2000)
    Springer
    Neurological sciences 21 (2000), S. S877 
    Details
    ISSN: 1590-3478
    Keywords: Key words Multiple sclerosis ; Magnetic resonance imaging ; Magnetization transfer imaging ; Diffusion-weighted imaging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conventional magnetic resonance imaging (MRI) has markedly increased our ability to detect the macroscopic abnormalities of the brain and spinal cord in patients with multiple sclerosis (MS). Magnetization transfer imaging and diffusion-weighted imaging have the potential to provide relevant and complementary information on the structural changes occurring within and outside these lesions and are contributing significantly to our understanding of the mechanisms leading to the accumulation of irreversible neurological disability in MS patients. These present review will summarize the major results achieved with the application of these two MR techniques to the assessment of the evolution of MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720070030
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