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  • 1
    Electronic Resource
    Electronic Resource
    Seltene Ursache bei Muskelschmerzen und erhöhter Creatinkinase – das paroxysmale nicht-hereditäre Angioödem (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 200-204 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Paroxysmales nicht-hereditäres Angioödem – Rhabdomyolyse – Myositis ; Key words¶Capillary leak syndrome – rhabdomyolysis – myositis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Systemic capillary leak syndrome is a rare idiopathic disorder characterized by recurrent episodes of hypotension and hemoconcentration due to sudden transient extravasation of up to 70% of plasma. Less than 40 cases have appeared in the literature. Mortality rates 5 years after diagnosis have been reported to be up to 75%. Clinical findings are generalized edema and intravasal fluid deficiency. Laboratory features include hypoalbuminemia and extreme hemoconcentration. A common finding is a monoclonal gammopathy. Rare manifestation of this syndrome is rhabdomyolysis due to increased compartment pressure and ischemic myonecrosis. Early diagnosis and exclusion of other clinical disorders like rheumatic myopathies and myositis are critical concerning prognosis and therapy. We describe a 46-year-old woman with rhabdomyolysis and systemic capillary leak syndrome whose condition is stable for a total of 30 months under a prophylactic regimen with oral terbutaline plus theophylline. A brief survey of the literature is given.
    Notes: Zusammenfassung Gefäßprozesse stellen bei vielen entzündlich-rheumatischen Erkrankungen die pathophysiologische Grundlage dar. Wir stellen ein Krankheitsbild vor, das durch rezidivierende Perioden erhöhter Kapillarpermeabilität mit ausgeprägtem Flüssigkeitsstrom in extravaskuläre Kompartimente gekennzeichnet ist. Das paroxysmale nicht-hereditäre Angioödem („Clarkson-Syndrom”) betrifft meist Patienten unter 50 Jahren, die 5-Jahres-Mortalität liegt bei bis zu 〉75%. Kardinalsymptome sind generalisierte Ödeme bei gleichzeitig intravasalem Volumenmangel, dadurch treten oft bedrohliche Schocksituationen auf. Laborchemisch pathognomonisch in der akuten Phase sind Hypoproteinämie und extreme Hämokonzentration. Gehäuft findet sich eine monoklonale Gammopathie. Die im Rahmen eines begleitenden Kompartmentsyndroms auftretende Rhabdomyolyse mit Anstieg der Creatinkinase und Myalgien stellt eine Differentialdiagnose zu entzündlich-rheumatischen Erkrankungen dar. Wir beschreiben eine 46-jährige Patientin mit Rhabdomyolyse, bei der im Verlauf die Diagnose eines paroxysmalen nicht-hereditären Angioödems gestellt wurde und geben einen kurzen Überblick über das Krankheitsbild.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930070081
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  • 2
    Electronic Resource
    Electronic Resource
    Application of classical models of chirality to surface second harmonic generation (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 6707-6715 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Two classical models (Kuhn and Kauzmann) are extended to calculate the second-order nonlinear response of an isotropic layer of chiral molecules. Calculation of the various nonlinear susceptibilities (electric dipolar, magnetic dipolar, and electric quadrupolar) is performed and applied to the derivation of the second harmonic field radiated by the molecules. It is shown that the two models give strikingly different results about the origin of the chiral response in such experiments. Previously published results are analyzed in view of this calculation which allows to understand the different interpretations proposed. This calculation emphasizes the interest of surface second harmonic generation to access information about the microscopic origin of optical activity in chiral molecules. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1404983
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  • 3
    Electronic Resource
    Electronic Resource
    Design and performance of a highly efficient mass spectrometer for molecular beams (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 2015-2018 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We present a very efficient 90° sector magnet mass spectrometer detector, based on electron impact ionization, especially adapted for the use with atomic and molecular beams. In this setup, a cylindrically symmetric magnetic field compresses electrons emitted from a large filament into a long, narrow volume containing primarily the molecular beam. This has the advantage of both producing as little as possible background from residual gases and increasing the interaction region between beam and ionizer. Experimental tests using thermal He atoms show that the detector's efficiency and sensitivity are very high, amounting to η≥0.70±0.04% and S=0.22±0.03 A mbar−1, respectively. The unconventionally long ionization volume, however, may restrict the use of this mass spectrometer to experiments with no, or only moderate timing requirements. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150570
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  • 4
    Electronic Resource
    Electronic Resource
    Dynamic study of the surfaces of (001) gallium arsenide in metal-organic vapor-phase epitaxy during arsenic desorption (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 1245-1250 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated by reflectance anisotropy spectroscopy the arsenic desorption from GaAs (001) at various temperatures in metal–organic vapor-phase epitaxy to obtain reaction orders and activation energies. The highest arsenic coverage, found at low temperatures with arsine stabilization, corresponds to a (4×3) reconstruction. Without arsine, arsenic starts to desorb and less arsenic-rich reconstructions are observed, depending on temperature: c(4×4) (below 800 K), β2(2×4) (below 920 K), α(2×4), and only with hydrogen carrier gas finally (4×2) (above 950 K). Above 920 K the reaction order differs in hydrogen and nitrogen atmosphere, probably due to an etching effect of hydrogen radicals. The five different desorption processes show either a first- or zero-order time dependence. First order is related to the desorption from the terraces and zero order to desorption from the steps (or kinks) on the surfaces. The activation energies for all processes are around 2.5 eV. This energy is, therefore, assumed to be the activation energy for the removal of an arsenic dimer from the surface. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372003
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  • 5
    Electronic Resource
    Electronic Resource
    Improvement of the discharge efficiency in plasma displays (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 2403-2408 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The dependence of the efficacy of an alternating current surface-discharge plasma display panel on the gas pressure is investigated for several Xe–Ne gas mixtures. In monochrome green 4 in. test panels the efficacy trends and emission spectra are examined for increasing gas pressure and/or Xe concentration. The measured panel efficacy and emission characteristics are compared with the results of a numerical discharge model. It is found that the discharge efficiency for the cell geometry used in present-day commercial products can be increased significantly by using a larger Xe partial pressure. An increase of the electron heating efficiency and of the Xe excitation efficiency contribute about equally to the efficacy increase. The contribution of the increasing Xe dimer radiation fraction to the efficacy improvement is relatively small. These findings are applied in a 4 in. color test display with a design that resembles the one used in present-day commercial products and contains a gas mixture of 13.5% Xe in Ne at 800 hPa. For realistic operating conditions an efficacy of 3.8 lm/W at a white luminance of 2010 cd/m2 is obtained. Furthermore, the panel chromaticity improves for increasing Xe partial pressure due to decreasing Ne emission. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1430896
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  • 6
    Electronic Resource
    Electronic Resource
    The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric anesthesia 14 (2004), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Congenital insensitivity to pain with anhidrosis (CIPA, or hereditary sensory and autonomic neuropathy type IV) is a rare, autosomal recessive disease, related to a mutation in the TrkA gene, characterized by inability to sweat, insensitivity to pain and recurrent episodes of hyperpyrexia. There are two Bedouin tribes in Israel with different mutations of the TrkA gene: one in the southern region and the other in the northern region. The Soroka University Medical Center is the referral centre for the entire southern region of Israel. One in 4500 anaesthesia cases involves a patient with CIPA.Methods : We reviewed 40 anaesthesia records of 20 patients with CIPA for anaesthetic technique and incidence of side-effects.Results : Sixteen patients developed complications in the immediate perioperative period: mild hypothermia in one patient and cardiovascular events in 15 others with one case of cardiac arrest. These complications were unrelated to the anaesthetic drug administered. There were no events of hyperthermia or postoperative nausea.Conclusions : Cardiovascular complications following anaesthesia are common in patients with the southern Israel variant of CIPA. Hyperthermia, previously recognized as a major concern in patients with congenital insensitivity to pain with anhydrous, was not seen in our patients. We conclude that cardiovascular involvement is frequently encountered in CIPA patients following anaesthesia and is the major concern in their anaesthetic management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2003.01235.x
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  • 7
    Electronic Resource
    Electronic Resource
    Ultra-relativistic electrons in Jupiter's radiation belts (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 415 (2002), S. 987-991 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Ground-based observations have shown that Jupiter is a two-component source of microwave radio emission: thermal atmospheric emission and synchrotron emission from energetic electrons spiralling in Jupiter's magnetic field. Later in situ measurements confirmed the existence of Jupiter's ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/415987a
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  • 8
    Electronic Resource
    Electronic Resource
    A phase II study of paclitaxel in chemonaïve patients with recurrent high-grade glioma (2000)
    Springer
    Annals of oncology 11 (2000), S. 409-413 
    Details
    ISSN: 1569-8041
    Keywords: paclitaxel ; quality-of-life ; recurrent high-grade glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:The prognosis of malignant gliomas remains poor. Inrecurrent disease, chemotherapy can be considered. Patients and methods:In this phase II study we determined theanti-tumour efficacy of paclitaxel 200 mg/m2 in a three-hourintravenous infusion every three weeks in chemonaïve patients withrecurrent high-grade glioma in terms of response, survival, and quality oflife. Results:In 17 patients (14 glioblastoma multiforme, 3 anaplasticastrocytoma) 69 paclitaxel cycles were administered. Partial or completeresponses were not observed. Stable disease for four to six months wasobserved in five patients (29%). Median time to progression and mediansurvival were two and 10 months, respectively. Toxicity due to paclitaxel wasas to be expected and minor in most cases. Quality of life and mood estimatesappeared rather stable over time. Conclusions:We conclude that three-weekly 200 mg/m2paclitaxel chemotherapy for patients with recurrent high-grade gliomas did notlead to major complications or adverse effects on quality of life and mood.However, this therapy is of only very limited value in terms of response andsurvival in such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008376123066
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