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  • 2000-2004  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To determine whether in-vitro sensitivity to cyclosporin as measured by a lymphocyte proliferation assay is predictive of in-vivo response to therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:The study comprised seven responders with ulcerative colitis, seven non-responders, and 14 healthy matched controls. A lymphocyte proliferation assay was carried out in the presence of a range of concentrations of cyclosporin and a dose–response curve constructed for each subject. The IC50 value, the concentration of cyclosporin that resulted in 50% inhibition of proliferation, was calculated for each subject. IC50 values for responders, non-responders and controls were compared using a Mann–Whitney test.〈section xml:id="abs1-4"〉〈title type="main"〉Results:There was a wide range of values obtained for the study group as a whole. IC50 values for non-responders were significantly higher than those of responders (P 〈 0.05).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:There is a population-wide variation of in-vitro sensitivity to cyclosporin. This is reflected in in-vivo sensitivity as measured by clinical response to cyclosporin treatment. Future therapeutic strategies need to address this inherent variability of individual response to therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Histopathology 38 (2001), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 26 (2000), S. 229-235 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper describes the results of computational simulations of a frontal impact to the head and the predicted development of coup and contrecoup contusion (i.e., at and opposite the site of impact, respectively) within brain tissue. Three separate two-dimensional plane strain finite element models of the head, each of which incorporated the skull, the cerebrospinal fluid and the brain, were constructed. Two of these models represented the coronal plane of the head as being elliptic whilst the third model was geometrically representative of an actual human head. This third model was taken in an off-centre mid-sagittal plane in an anterior–posterior direction and all three models were used to investigate the dynamic response of the human head when subject to direct translational impact events. The physiological consequences of modelling the human brain as being elastic were established. Compressive and tensile strains were predicted at the coup and contrecoup sites for a simulated frontal impact event by means of a simple elastic analysis. These distributions of most severe strain correspond directly to the occurrence of coup and contrecoup contusion such as are witnessed in clinical studies which arise under the action of translational acceleration.
    Type of Medium: Electronic Resource
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