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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 29 (1937), S. 394-397 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 1012-1014 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the European spallation source, a volume source based on the high efficiency source is being developed. The source will be optimized to produce high current densities in pulsed operation. A pulse generator delivering 1–1.5 ms pulses was installed. Furthermore, cesium was supplied to the plasma generator from an external oven. The cesium injection was optimized for a low e/H− ratio and a high current. We obtained a current density of 70 mA/cm2. This way, with an aperture radius of 4.25 mm, an H− current of 40 mA was extracted at an extraction voltage of 22 kV. After a description of the source and the experimental setup, measurements of the beam current density and the e/H− ratio will be presented in this article. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2698-2706 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Among the various possibilities for investigating the properties of ion beams, two of the most important principles for determining the beam quality are profile measurements using wires or slit apertures, and different kinds of emittance measurement devices. However, most of the commonly used systems have the disadvantage of being either destructive to the beam, or at least to have a considerable influence on the further beam propagation downstream of the point of measurement. Also, for the investigation of intense ion beams, thermal problems on the scanners themselves might arise. Observation of particles emitted from the ion beam in radial direction allow an indirect but nondestructive observation of the beam. Of the different optical methods that exist to accomplish this, we recently conducted an investigation on the possibilities to employ a charge coupled device-camera system for such nondestructive beam diagnostics in our space-charge compensation test stand. First, experimental results on optical profile measurements are presented and compared to results obtained by a slit scanner and a wire scanner. Additionally, to gain a better understanding of the measured data, optically obtained sectional profiles behind a slit and a circular aperture were analyzed. Possibilities for gaining information on the two-dimensional beam profile and the beam emittance are explored. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1039-1041 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new version of the high efficiency source is being developed for the European Spallation Source. The goal of these experiments is to produce a nearly pure H− ion beam with a low electron to H− ratio and high current (70 mA). To achieve this, the discharge chamber is divided into two parts of different plasma parameters by means of a filter magnetic field. Furthermore, the plasma chamber is aligned unsymmetrically with respect to the z axis of the extractor. We obtained a current density of 10 mA/cm2 for an arc power as small as 1 kW. In preliminary experiments, a beam of 10 mA was extracted at an extraction voltage of 8 kV (1.8% impurities). Measurements of the beam current density, electron to H− ratio, and the ion composition for a wide range of discharge conditions will be presented in this article. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1054-1056 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A volume source, based on the high efficiency ion source (HIEFS), is being developed for D+ production in steady state operation. The source will be optimized for the extraction of atomic deuterium ions with high current densities. It was found that a maximum deuterium ion beam current density of 210 mA/cm2 can be achieved with a D+ fraction above 90%. At an extraction voltage of 35 kV and with an aperture radius of 4 mm, the source delivers 61 mA D+. After a description of the source and the experimental setup, the results of detailed studies of the beam composition in dependence of the plasma parameters are presented. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 1066-1068 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A volume source based on the high efficiency source is being developed for heavy ion production. Bismuth was chosen for exemplifying investigations because of its low melting point. The ion source is driven by an arc discharge ionizing bismuth atoms which are evaporated from an oven inside the source chamber. It has been optimized to produce a beam with a fraction of singly ionized bismuth above 92%. A multiaperture extraction system was built consisting of seven holes with a radius of 3 mm each. For that system, the perveance limit was achieved at a beam current of 70 mA and an extraction voltage of 27.5 kV. The corresponding emission current density amounts to 35 mA/cm2. This value was obtained for an arc power of only 280 W. Furthermore, the emittance of a beam extracted from the multiaperture extraction system has been determined with a high power emittance scanner. It amounts to 0.27π mm mrad (80%, normalized, 4 rms). In this case, the emittance of a single beam is 0.017π mm mrad. This article will give a detailed description of both the source and the experimental setup. In addition, various dependencies between the plasma parameters and the beam composition are presented. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bone marrow derived stromal cells are of mesenchymal origin and precursor cells for skeletal tissue components such as chondroblasts and osteoblasts. Furthermore, under experimental conditions, a differentiation potency into myogenic and neuronal cells could be demonstrated. Because of their multipotency these cells represent a population of non-haematogen stem cells that can be regarded as an alternative to human embryonic stem cells for future autologous cell replacement therapies. For a closer look at the differentiation capacity of these cells, rat and human bone marrow stromal cells were isolated from the femur bone and kept in the cell culture applying different cultivation protocols. In a cultivation medium with a serum content of 20%, the majority of these cells express a variety of neuronal markers such as ß-III Tubulin and NeuN as well as the astrocyte marker GFAP, while a minority of about 20% express the marker for neural precursor cells nestin. Cultivation in a chemically defined serum free medium results in the differentiation of a markedly higher percentage of nestin positive neural precursor-like cells. Using bFGF in combination with B27 these cells can be forced to form three dimensionally organized spheres. In order to elucidate a possible therapeutical potency of the bone marrow derived cells the synthesis of neurotrophic factors such as BDNF and NGF were analysed using the ELISA technique. Furthermore, they can be infected using a third generation adenoviral vector with high efficiency and show migratory activity in vitro. After injection of bone marrow derived mesenchymal stem cells into the lateral ventricle of adult rats they adhere to the ependymocytes and pass the ependymal barrier in order to settle in the subventricular space.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 1003-1007 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Brain injury remains a significant and potentially devastating outcome of cardiopulmonary bypass (CPB) under circulatory arrest. These outcomes caused by a microvasculature embolization are associated with increased mortality, longer hospital stays and increased use of intermediate or long term care facilities. The administration of heparin in heart surgery during deep hypothermic cardiopulmonary bypass is the basic prophylactic strategy for reducing or even preventing, microvasculature embolization. Unfortunately, an incidence of neuropsychological impairments (NPI) is found in as many as 25 % of the survivors. As it is suspected that these impairments are correlated with morphological alterations, in our study we use the GP IIb-IIIa receptor blocker Eptifibatide for the inhibition of platelet aggregation, in order to look for a reduction of tissue damage compared to the standard treatment. Two groups of 11 piglets (mean body weight of 15±5 kg) underwent 10-minute normothermic bypass, 40-minute cooling on cardiopulmonary bypass, 60-minutes deep hypothermic circulatory arrest (DHCA) at 15°C, and 40-minute rewarming to 37°C. Group 1 was treated only with unfractionated heparin (UFH), whereas Group 2 was medicated with Eptifibatide, in addition to the UFH-treatment group 1. After rewarming, all animals underwent bilateral carotid perfusion with 4% paraformaldehyde. Histological investigations of semi thin sections reveal a marked decrease of hippocampal alterations by using the GP IIb-IIIa receptor blocker in addition to standard UFH treatment. We detect a reduction of degenerative areas in perivascular (vessels with 10–30 μm in diameter) tissue. These semi-quantitative data are confirmed by ultrastructural findings.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 77-84 
    ISSN: 1437-1588
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Darüber hinaus soll das Lebensmittel-Monitoring längerfristig dazu dienen, zeitliche Trends in der Belastung von Lebensmitteln aufzuzeigen und eine ausreichende Datenbasis zu schaffen, um Aufnahmeberechnungen von unerwünschten Stoffen, die der Verbraucher über die Nahrung aufnimmt, durchführen zu können.
    Type of Medium: Electronic Resource
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