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  • 1
    Electronic Resource
    Electronic Resource
    Mutation in the mitochondrial tRNAleu at position 3243 and spontaneous abortions in Japanese women attending a clinic for diabetic pregnancies (1995)
    Springer
    Diabetologia 38 (1995), S. 809-815 
    Details
    ISSN: 1432-0428
    Keywords: Key words Mitochondrial DNA mutation ; insulin-dependent diabetes mellitus ; non-insulin-dependent diabetes mellitus ; gestational diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitochondrial DNA is exclusively maternally inherited. We recently found the prevalence of diabetic patients with an A to G transition at position 3243 of leucine tRNA (3243 base pair (bp) mutation) to be nearly 1 % in randomly selected Japanese subjects. Here, we report the higher prevalence of diabetic patients with the 3243 bp mutation in a specific Japanese population of women attending a diabetic pregnancy clinic. Of 102 patients with non-insulin-dependent diabetes mellitus 6 (5.9 %) were positive for the mutation, 1 (8.3 %) of 12 patients with gestational diabetes and 2 (5.9 %) out of 34 borderline diabetic patients. In contrast, none of 64 patients (0 %) with insulin-dependent diabetes mellitus had the 3243 bp mutation. Moreover, there was a difference in the prevalence of spontaneous abortions between patients with and without this mutation (27.3 vs 12.4 %). Among nine probands with the mutation, four had a history of one spontaneous abortion (p = 0.0518) and two had a history of two abortions (p = 0.0479). Two probands had a spontaneous abortion even while under strict diabetic metabolic control. The 3243 bp mutation thus may cause spontaneous abortion during pregnancy. [Diabetologia (1995) 38: 809–815]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050357
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  • 2
    Electronic Resource
    Electronic Resource
    Expression and function of the ST2 gene in a murine model of allergic airway inflammation (2002)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background We have recently reported that soluble ST2 protein levels are elevated in the sera of patients with asthma, and correlate well with the severity of asthma exacerbation. However, the role, function, and kinetics of soluble ST2 expression in asthma remain unclear.Objective The objective of the present study was to clarify the function and kinetics of soluble murine (m) ST2 expression in a murine asthma model.Methods We analyzed the kinetics of gene and protein expression of mST2 in sera or lung tissue after allergen (ovalbumin; OVA) challenge in a murine model of allergic airway inflammation, the effects of mST2 protein on OVA-induced Th2 cytokine production in vitro from splenocytes of sensitized mice, and the effects of soluble mST2 on Th2-dependent allergic airway inflammation by in vivo gene transfer of mST2.Results Serum mST2 protein levels increased to the maximal level 3 h after the allergen challenge, before serum IL-5 levels peaked. The mRNA expression of mST2 in lung tissue was induced after the allergen challenge, while that in the spleen was constitutively detected. Furthermore, pre-treatment with mST2 protein significantly inhibited the production of IL-4 and IL-5, but not IFN-γ, from OVA-stimulated splenocytes in vitro, and intravenous mST2 gene transfer resulted in a drastic reduction in the number of eosinophils and in the levels of IL-4 and IL-5 in bronchoalveolar lavage fluid, compared with those in response to transfer of non-coding plasmid vector or of lipid alone.Conclusion These results suggest that increases in endogenous mST2 protein after allergen exposure may modulate Th2-mediated airway inflammation, and that in vivo gene transfer of mST2 can be applicable to use in a novel immunotherapy for allergic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2745.2002.01494.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cardiopulmonary function in bicycle racing over mountainous terrain at moderate altitude (1995)
    Springer
    International journal of biometeorology 38 (1995), S. 126-130 
    Details
    ISSN: 1432-1254
    Keywords: Bicycle racing ; Cardiopulmonary function ; Moderate altitude
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract To examine cardiopulmonary function during exercise in a mountainous region at moderate altitude, we measured cardiac frequency, oxygen consumption $$\left( {\dot VO_2 } \right)$$ , and percentage arterial hemoglobin oxygen saturation (%SaO2) before and after a bicycle race with a starting point at 638 m and finishing point at 1980 m. The time required to ascend an elevation of 10 m was prolonged with increasing altitude, and heart rate also increased with altitude. The %SaO2 at the starting point and at the finishing point differed significantly (P〈0.01). Faster cyclists exhibited higher %SaO2 and lower $$\dot VO_2 $$ , while slower cyclists exhibited a reduction in %SaO2 and an increase in $$\dot VO_2 $$ immediately after the race. The %SaO2 recovery time was significantly correlated with the racing time (r=0.54,P〈0.001). Therefore, the faster cyclists' oxygen debt upon completion of the race may be small and recovery of cardiopulmonary function may be fast, while the slower cyclists' oxygen debt may be large and recovery of cardiopulmonary function may be slow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208488
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of muscle force, muscle endurance, and electromyogram activity during an expedition at high altitude (1996)
    Springer
    International journal of biometeorology 39 (1996), S. 111-115 
    Details
    ISSN: 1432-1254
    Keywords: Acclimatization ; High altitude ; Muscle power ; Muscle endurance ; EMG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Handgrip force (HF), maximal pinch force (MF), muscle endurance (ME), and the median power frequency (MdPF) of the activity shown in the electromyogram (EMG) were studied at various altitudes in eight normal healthy subjects. MF and ME were measured between the index finger and thumb, and all measurements were obtained at altitudes ranging from 610 to 4860 m during an expedition in the Qinghai Plateau in China. With the change in altitude HF, ME, and MF showed no significant change. Compared to the MdPF at 2260 m on ascent, the MdPF at other altitudes showed a significant decrease (P〈0.01). Thus, we conclude that muscle performance (HF, MF, and ME) was not affected by the environment at high altitude. However, MdPF was affected and the mean MdPF at 610 m after the expedition did not recover to initial values of MdPF. We suggest these results may have been affected by fatigue and chronic exposure to the hypobaric hypoxic environment, since the members of the expedition party expressed feelings of sluggishness and fatigue after the expedition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211221
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  • 5
    Electronic Resource
    Electronic Resource
    The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization (2000)
    Springer
    Molecular genetics and genomics 263 (2000), S. 514-519 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsDictyostelium discoideum ; Mitochondrial DNA ; Genome sequencing ; Genetic map ; Evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We present an overview of the gene content and organization of the mitochondrial genome of Dictyostelium discoideum. The mitochondria genome consists of 55,564 bp with an A + T content of 72.6%. The identified genes include those for two ribosomal RNAs (rnl and rns), 18 tRNAs, ten subunits of the NADH dehydrogenase complex (nad1, 2, 3, 4, 4L, 5, 6, 7, 9 and 11), apocytochrome b (cytb), three subunits of the cytochrome oxidase (cox1/2 and 3), four subunits of the ATP synthase complex (atp1, 6, 8 and 9), 15 ribosomal proteins, and five other ORFs, excluding intronic ORFs. Notable features of D. discoideum mtDNA include the following. (1) All genes are encoded on the same strand of the DNA and a universal genetic code is used. (2) The cox1 gene has no termination codon and is fused to the downstream cox2 gene. The 13 genes for ribosomal proteins and four ORF genes form a cluster 15.4 kb long with several gene overlaps. (3) The number of tRNAs encoded in the genome is not sufficient to support the synthesis of mitochondrial protein. (4) In total, five group I introns reside in rnl and cox1/2, and three of those in cox1/2 contain four free-standing ORFs. We compare the genome to other sequenced mitochondrial genomes, particularly that of Acanthamoeba castellanii.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008685
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  • 6
    Electronic Resource
    Electronic Resource
    Simple Aquatic Microcosm for Ecotoxicity Screening at the Community Level (2000)
    Springer
    Bulletin of environmental contamination and toxicology 65 (2000), S. 699-706 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0012800180
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  • 7
    Electronic Resource
    Electronic Resource
    Hardening of hydrothermal hot pressed calcium silicate compacts with rice husk as fiber reinforcement (2000)
    Springer
    Materials research innovations 3 (2000), S. 297-301 
    Details
    ISSN: 1433-075X
    Keywords: Key words Calcium silicates ; Hydrothermal hot pressing ; Rice husk ; Tensile strength
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Hydrothermal hot-pressing (HHP) technique was used to solidify calcium silicate hydrate powders at a relatively low temperature as 200°C and low pressure (20 MPa) with short reaction time (30 min). Diatomaceous earth, α-quartz, fly ash and silicic acid were used as the Si sources. Waste rice husk was used for fiber reinforcement to strength the hydrothermal hot pressed calcium silicate compacts. The tensile strength of the solidified bodies with and without rice husk was tested. The solidified bodies with reinforced by 5% rice husk exhibit high tensile strength (∼9 MPa), which is almost three times lager than their non-additives compacts. There is no effect of additives for the density of solidified bodies, which remains almost constant at ∼2gcm–3 similar to their non-additive compacts. The developed low temperature solidification method is expected to be useful in the development of an environmentally friendly processing route for making artificial wood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100190000048
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of synthesis parameters on the formation of birnessite-type manganese oxides (2000)
    Springer
    Journal of materials science 19 (2000), S. 1567-1570 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006733308073
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  • 9
    Electronic Resource
    Electronic Resource
    Characterization of birnessite-type sodium manganese oxides prepared by hydrothermal reaction process (2000)
    Springer
    Journal of materials science 19 (2000), S. 2047-2050 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026791825617
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  • 10
    Electronic Resource
    Electronic Resource
    Infrared Study of Some Synthetic and Natural Beidellites (1998)
    Springer
    Journal of materials science 17 (1998), S. 1853-1855 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006694629015
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