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  • 1
    Digitale Medien
    Digitale Medien
    Beam tests of a compact 2.45 GHz electron cyclotron resonance ion source : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1171-1173 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: A compact 2.45 GHz ECR ion source has been developed at National Institute of Radiological Sciences (NIRS). The source was designed to provide doubly charged carbon ions, aiming at easy maintenance of the source. A set of permanent magnets was adopted to realize a minimum B structure. In pulse operation with a duty factor of 5%, the beam performance was measured with He, CO2, CH4, and N2 gases. With CO2 gas, analyzed beam currents are 160 and 15 eμA for C+ and C2+, respectively. Through the measurement of the microwave amplitude in the plasma chamber, it was found that the microwave power was not transmitted into the plasma chamber efficiently. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1146722
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  • 2
    Digitale Medien
    Digitale Medien
    Status of ion sources for the Heavy Ion Medical Accelerator HIMAC : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 962-964 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS) is the first heavy-ion accelerator complex dedicated to cancer therapy. HIMAC is equipped with two kinds of ion sources. The PIG ion source is an indirectly heated cathode type, which is operated with a very low-duty factor. The ECR ion source has a single closed ECR zone with 10 GHz microwaves. Both sources realize good stability and reproducibility with easy operation, and satisfy the requirements for radiotherapy. They have been successfully used for clinical trials since June of 1994, and several tens of cancer patients have already been treated with 290–400 MeV/u carbon beams. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1146784
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  • 3
    Digitale Medien
    Digitale Medien
    Development of the National Institute of Radiological Sciences electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba : Proceedings of the 5th international conference on ion sources (1994)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 1087-1089 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The development of an electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba (HIMAC) injector is reported. The HIMAC is a heavy ion medical accelerator for cancer therapy. The electron cyclotron resonance (ECR) ion source is expected to provide a long lifetime, easy operation, and easy maintenance for medical use. The NIRS-ECR ion source has a single closed ECR stage, and a microwave frequency of 10 GHz is applied. Under the present performance, the output electrical currents of the ions are 2500 eμA for He1+, 300 eμA for C2+, 480 eμA for Ne3+, and 110 eμA for Ar6+. Stability of the intensity is better than 2%. The transmission efficiency through a low-energy beam-transport line with an acceptance of 200 πmm mrad is more than 70%; the typical 50% and 90% emittances of the injection beam with 8 keV/u are 20 and 80 πmm mrad, respectively. These performances satisfy the requirements for radiotherapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1145071
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  • 4
    Digitale Medien
    Digitale Medien
    Longitudinal impedance tuner using new material FINEMET (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 2988-2992 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: We designed an impedance tuner consisting of an inductive material, FINEMET, to cancel the space charge impedance in the longitudinal direction. It was installed in the KEK Proton Synchrotron (PS) main ring. We observed the frequency shift of the coherent quadrupole oscillations and inferred the shift of the incoherent synchrotron oscillation. The total reactive impedance can be estimated as the coefficient between the shift and the beam intensity. The measured impedance is reduced from −j2475Ω to −j1182Ω by the impedance tuner which consists of 12 pieces of FINEMET cores. We demonstrated that the space charge impedance is compensated by the impedance tuner. This is the first time for FINEMET to be equipped with an accelerator component. One may think that the characteristics of FINEMET deteriorate under an environment with strong radiation generated by unavoidable beam loss. We have proved that the radiation dose not affect FINEMET even with a total neutron dose of 1.83×1012(n cm−2), which is considered to be the highest dose of the main ring. © 1999 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1149859
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  • 5
    Digitale Medien
    Digitale Medien
    Observations on the muscle plasma membrane-associated cytoskeletons of mdx mice by quick-freeze, deep-etch, rotary-shadow replica method (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 618-623 
    Details
    ISSN: 1432-0533
    Schlagwort(e): mdx and control mice muscles ; Dystrophin ; Quick-freeze, deep-etch, rotary-shadow replica ; Muscle plasma membrane-associated cytoskeletons
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The Duchenne muscular dystrophy gene product “dystrophin” is a sarcolemma-associated cytoskeleton which is present just inside the sarcolemma. We investigated the ultrastructure and the relationship of this cytoskeleton to the muscle plasma membrane by immunoelectron microscopy and freeze-etch electron microscopy of liquid helium-frozen fresh muscles. The immunoelectron microscopy of the extensor digitorum longus muscles of six mdx mice and six control mice showed the location of anti-dystrophin antibody along the muscle plasma membrane undercoat of all the muscle samples from the control mice without any antibody reaction in the mdx mice muscles. Fresh extensor digitorum longus muscles of seven mdx and six control mice were quick-frozen in liquid helium in the rapid-freeze device. High-magnification electron microscopy of the deep-etch, rotary-shadow replicas of the frozen muscles showed the network formation and attachment of individual rod-shaped cytoskeletons of variable size to the cytoplasmic surface of the muscle plasma membrane in both mdx mice and control mice. The length of cytoskeletons attached to the muscle plasma membranes was measured and mean length±SE in mdx mice and control mice were 98±4 nm and 101±3 nm, respectively. Although these values were not statistically different (P〉0.1), the distribution frequency of 130–150 nm muscle plasma membrane-associated cytoskeletons was 7.9% in mdx mice versus 14.5% in control mice. Since the predicted length of dystrophin is 125–150 nm, the 130- to 150-nm plasma membrane-associated cytoskeletons of mdx control mice may include dystrophin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00307629
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  • 6
    Digitale Medien
    Digitale Medien
    Gold-labelled dystrophin molecule in muscle plasmalemma of mdx control mice as seen by electron microscopy of deep etching replica (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 178-184 
    Details
    ISSN: 1432-0533
    Schlagwort(e): mdx and control mice muscles ; Quick-freeze, deep-etch, rotary-shadow replica ; Gold-labelled dystrophin ; Shape of dystrophin molecule
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The Duchenne muscular dystrophy product ‘dystrophin’ has been shown to be located at the inner surface of normal muscle plasma membrane. This study was undertaken to visualize the shape of dystrophin molecules and their topographical distribution at the inner surface of murine skeletal muscle plasma membrane. The immunogold electron microscopy of plastic-embedded quadriceps femoris muscles of six mdx mice and six control mice showed the presence of gold particles along the muscle plasma membrane undercoat of all muscle samples from the control mice without any antibody reaction in the mdx mice muscles. The gold-labelled muscles of six mdx and six control mice were quickly frozen by liquid helium in a rapid-freeze apparatus. High magnification electron microscopy of the quick-freeze, deep-etch, rotary-shadow replicas of the gold-labelled muscles demonstrated the presence of dystrophin molecules associated with gold particles at the cytoplasmic surface of mdx control mice. The dystrophin molecules displayed a variety of shapes, such as rods with a reduction in diameter from one end to the other end and/or with the enlargement of their end(s). These dystrophin molecules were incorporated in the meshowork of muscle plasma membrane-associated cytoskeletons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294443
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  • 7
    Digitale Medien
    Digitale Medien
    Transjugular retrograde obliteration for gastric varices (1996)
    Springer
    Abdominal imaging 21 (1996), S. 299-303 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Key words: Gastric varices—Gastrorenal shunt—Transjugular retrograde obliteration.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. We evaluated the transjugular retrograde obliteration (TJO) in treatment of gastric varices with gastrorenal shunt. Twenty patients with posthepatitic cirrhosis were included in this study. A cobra-shaped 5 French occlusive balloon catheter was inserted into the gastric varices or gastrorenal shunt through the internal jugular vein. As the sclerosants, absolute ethanol and 5% ethanolamine oleate with iopamidol were injected into the varices to make thrombi. In all cases, gastric varices were obliterated successfully. Endoscopic examination 3 months after treatment revealed the complete eradication of gastric varices in all cases. No major complications during or after therapy were observed. We think that TJO can be an effective method for the treatment of gastric varices with gastrorenal shunt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002619900068
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  • 8
    Digitale Medien
    Digitale Medien
    Percutaneous transhepatic obliteration for esophagojejunal varices after total gastrectomy (1998)
    Springer
    Abdominal imaging 23 (1998), S. 560-562 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Key words: Esophagojejunal varices—Percutaneous transhepatic obliteration—Total gastrectomy.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. A 59-year-old man experienced hematemesis 5 years after a total gastrectomy and Roux-en-Y esophagojejunostomy for carcinoma of the cardia. Endoscopic examination revealed the esophagojejunal blue small varices with cherry-red spots. Percutaneous transhepatic portography showed that the varices were supplied by the vein of the ascending jejunal limb. The 3-French microcatheter was inserted into this vein through the 5-French catheter, and 0.5 mL of absolute ethanol and 2 mL of ethanolamine oleate with iopamidol were injected, which visualized the esophagojejunal varices and obliterated varices at the same time. There were no complications during the operation, and the subsequent clinical course showed no further bleeding. We conclude that percutaneous transhepatic obliteration with a 3-French microcatheter is one of the most effective means of treating esophagojejunal small varices arising after a total gastrectomy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002619900403
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