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  • 1
    Electronic Resource
    Electronic Resource
    Sterically Stabilized Colloidal Particles as Model Hard Spheres (1994)
    s.l. : American Chemical Society
    Langmuir 10 (1994), S. 3550-3554 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00022a030
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  • 2
    Electronic Resource
    Electronic Resource
    A superposed epoch analysis of geomagnetic storms (1994)
    Springer
    Annales geophysicae 12 (1994), S. 612-624 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A superposed epoch analysis of geomagnetic storms has been undertaken. The storms are categorised via their intensity (as defined by the Dst index). Storms have also been classified here as either storm sudden commencements (SSCs) or storm gradual commencements (SGCs, that is all storms which did not begin with a sudden commencement). The prevailing solar wind conditions defined by the parameters solar wind speed (vsw), density (〈rho〉sw) and pressure (Psw) and the total field and the components of the interplanetary magnetic field (IMF) during the storms in each category have been investigated by a superposed epoch analysis. The southward component of the IMF, appears to be the controlling parameter for the generation of small SGCs (-100 nT〈 minimum Dst\leq-50 nT for\geq4 h), but for SSCs of the same intensity solar wind pressure is dominant. However, for large SSCs (minimum Dst\leq-100 nT for \geq4 h) the solar wind speed is the controlling parameter. It is also demonstrated that for larger storms magnetic activity is not solely driven by the accumulation of substorm activity, but substantial energy is directly input via the dayside. Furthermore, there is evidence that SSCs are caused by the passage of a coronal mass ejection, whereas SGCs result from the passage of a high speed/ slow speed coronal stream interface. Storms are also grouped by the sign of Bz during the first hour epoch after the onset. The sign of Bz at t=+1 h is the dominant sign of the Bz for \sim24 h before the onset. The total energy released during storms for which Bz was initially positive is, however, of the same order as for storms where Bz was initially negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-994-0612-4
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  • 3
    Electronic Resource
    Electronic Resource
    SuperDARN studies of the ionospheric convection response to a northward turning of the interplanetary magnetic field (1998)
    Springer
    Annales geophysicae 16 (1998), S. 549-565 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (Auroral ionosphere) ; Magnetospheric physics (Magnetopause, cusp, and boundary layers; Magnetosphere-ionosphere interaction)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The response of the dayside ionospheric flow to a sharp change in the direction of the interplanetary magnetic field (IMF) measured by the WIND spacecraft from negative Bz and positive By, to positive Bz and small By, has been studied using SuperDARN radar, DMSP satellite, and ground magnetometer data. In response to the IMF change, the flow underwent a transition from a distorted twin-cell flow involving antisunward flow over the polar cap, to a multi-cell flow involving a region of sunward flow at high latitudes near noon. The radar data have been studied at the highest time resolution available (∼2 min) to determine how this transition took place. It is found that the dayside flow responded promptly to the change in the IMF, with changes in radar and magnetic data starting within a few minutes of the estimated time at which the effects could first have reached the dayside ionosphere. The data also indicate that sunward flows appeared promptly at the start of the flow change (within ∼2 min), localised initially in a small region near noon at the equatorward edge of the radar backscatter band. Subsequently the region occupied by these flows expanded rapidly east-west and poleward, over intervals of ∼7 and ∼14 min respectively, to cover a region at least 2 h wide in local time and 5° in latitude, before rapid evolution ceased in the noon sector. In the lower latitude dusk sector the evolution extended for a further ∼6 min before quasi-steady conditions again prevailed within the field-of-view. Overall, these observations are shown to be in close conformity with expectations based on prior theoretical discussion, except for the very prompt appearance of sunward flows after the onset of the flow change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-998-0549-0
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  • 4
    Electronic Resource
    Electronic Resource
    Ionospheric convection during the magnetic storm of 20–21 March 1990 (1994)
    Springer
    Annales geophysicae 12 (1994), S. 1174-1191 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We report on the response of high-latitude ionospheric convection during the magnetic storm of March 20–21 1990. IMP-8 measurements of solar wind plasma and interplanetary magnetic field (IMF), ionospheric convection flow measurements from the Wick and Goose Bay coherent radars, EISCAT, Millstone Hill and Sondrestrom incoherent radars and three digisondes at Millstone Hill, Goose Bay and Qaanaaq are presented. Two intervals of particular interest have been identified. The first starts with a storm sudden commencement at 2243 UT on March 20 and includes the ionospheric activity in the following 7 h. The response time of the ionospheric convection to the southward turning of the IMF in the dusk to midnight local times is found to be approximately half that measured in a similar study at comparable local times during more normal solar wind conditions. Furthermore, this response time is the same as those previously measured on the dayside. An investigation of the expansion of the polar cap during a substorm growth phase based on Faraday’s law suggests that the expansion of the polar cap was nonuniform. A subsequent reconfiguration of the nightside convection pattern was also observed, although it was not possible to distinguish between effects due to possible changes in By and effects due to substorm activity. The second interval, 1200–2100 UT 21 March 1990, included a southward turning of the IMF which resulted in the Bz component becoming -10 nT. The response time on the dayside to this change in the IMF at the magnetopause was approximately 15 min to 30 min which is a factor of \sim2 greater than those previously measured at higher latitudes. A movement of the nightside flow reversal, possibly driven by current systems associated with the substorm expansion phases, was observed, implying that the nightside convection pattern can be dominated by substorm activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-994-1174-1
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  • 5
    Electronic Resource
    Electronic Resource
    Variations in the polar cap area during intervals of substorm activity on 20–21 March 1990 deduced from AMIE convection patterns (1996)
    Springer
    Annales geophysicae 14 (1996), S. 879-887 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The dynamic behaviour of the northern polar cap area is studied employing Northern Hemisphere electric potential patterns derived by the Assimilative Mapping of Ionospheric Electrodynamics (AMIE) procedure. The rate of change in area of the polar cap, which can be defined as the region of magnetospheric field lines open to the interplanetary magnetic field (IMF), has been calculated during two intervals when the IMF had an approximately constant southward component (1100- 2200 UT, 20 March 1990 and 1300–2100 UT, 21 March 1990). The estimates of the polar cap area are based on the approximation of the polar cap boundary by the flow reversal boundary. The change in the polar cap area is then compared to the predicted expansion rate based on a simple application of Faraday’s Law. Furthermore, timings of magnetospheric substorms are also related to changes in the polar cap area. Once the convection electric field reconfigures following a southward turning of the IMF, the growth rate of the observed polar cap boundary is consistent with that predicted by Faraday’s Law. A delay of typically 20 min to 50 min is observed between a substorm expansion phase onset and a reduction in the polar cap area. Such a delay is consistent with a synthesis between the near Earth neutral line and current disruption models of magnetospheric substorms in which the dipolarisation in the magnetotail may act as a trigger for reconnection. These delays may represent a propagation time between near geosynchronous orbit dipolarisation and subsequent reconnection further down tail. We estimate, from these delays, that the neutral X line occurs between \sim35RE and \sim75RE downstream in the tail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-996-0879-8
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  • 6
    Electronic Resource
    Electronic Resource
    The response of the magnetosphere to the passage of a coronal mass ejection on March 20–21 1990 (1997)
    Springer
    Annales geophysicae 15 (1997), S. 671-684 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The geomagnetic response to the passage of a coronal mass ejection (CME) is studied. The passage of the CME resulted in a storm sudden commencement (SSC) at 2243 UT on March 20 1990 with disturbed magnetic activity during the following 24 h. The auroral, sub-auroral and equatorial magnetic response to the southward turning at 1314 (±5) UT on March 21 and the equatorial response to the southward turning associated with the SSC on 20 March are discussed in terms of existing models. It is found that the auroral and sub-auroral response to the southward turning associated with the SSC is a factor 2 or more quicker than normal due to the shock in the solar wind dynamic pressure. The low-latitude response time to the south-ward turning, characterised by Dst and the magneto-pause current corrected Dst*, is una.ected by the shock. Dst and Dst*, characteristic of the equatorial magnetic field, responded to the 1314 (±5) UT southward turning prior to the first observed substorm expansion phase onset, suggesting that a dayside loading process was responsible for the initial enhancement in the ring current rather than nightside particle injection. The response time of the auroral and sub-auroral magnetic field to the southward turning at 1314 (±5) UT on March 21 is measured at a variety of longitudes and latitudes. The azimuthal propagation velocity of the response to the southward turning varied considerably with latitude, ranging from #x0223C;8 km s−1 at 67°N to ∼4 kms−1 at 55°N. The southward velocity of the equatorward boundary of the northern polar convection pattern has been measured. This velocity was ∼1.2 km s−1 at 1600 MLT, although there was evidence that this may vary at different local times.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-997-0671-4
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  • 7
    Electronic Resource
    Electronic Resource
    UVB therapy decreases the adhesive interaction between peripheral blood mononuclear cells and dermal microvascular endothelium, and regulates the differential expression of CD54, VCAM-1, and E-selectin in psoriatic plaques (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A dermal lymphocytic infiltrate is a characteristic feature of psoriasis, and may be involved in the pathogenesis of the disease. We have previously shown that specialized dermal microvascular endothelial cells (DMEC) in psoriatic lesions promote the selective adherence of the CD4 CD45Ro helper T-cell subset. In this study, we examined the adhesive interaction between peripheral blood mononuclear cells and psoriatic DMEC in patients treated with ultraviolet B light (UVB), and correlated the results with the expression and function of endothelial adhesion molecules on DMEC. Seven psoriatic patients were exposed to one MED of UVB daily for 14 days, and the binding properties of their peripheral blood mononuclear cells (PBMC), and tissue specimens taken from their lesions on days 0, 2, 3, 6, 8, 11 and 14 of UVB treatment, were studied. The ability of psoriatic PBMC to adhere to non-irradiated control or UVB-treated psoriatic plaques was reduced by 70% after treatment with 2–3 MED, and complete inhibition was obtained after 8–11 MED. In contrast, exposure of psoriatic plaques to 2–3 MED had no effect on the capacity of DMEC to support normal PBMC binding, which was only reduced after 8–11 MED. In addition, psoriatic plaques which were shielded from direct UVB exposure also showed decreased PBMC binding, suggesting a systemic effect of UVB treatment. Immunoperoxidase staining revealed that CD54 (ICAM-1) and E-selectin were strongly expressed on dermal vessels in untreated psoriatic plaques. Treatment of patients with 6–8 MED significantly decreased CD54 and E-selectin, but was markedly induced following UVB treatment. In functional blocking studies, preincubation of tissue from untreated psoriatic plaques with anti-E-selectin antibody, but not antibodies against CD54 and VCAM-1, significantly inhibited the ability to bind normal PBMC. These observations suggest that UVB treatment interferes with the adhesive properties of both psoriatic PBMC and endothelial cells, and differentially regulates the expression of endothelial adhesion molecules. The study also provided direct evidence for the involvement of E-selectin in the adhesion of circulating lymphocytes to psoriatic endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-750.x
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  • 8
    Electronic Resource
    Electronic Resource
    Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls (1991)
    Springer
    Experimental brain research 85 (1991), S. 335-348 
    Details
    ISSN: 1432-1106
    Keywords: MPTP ; Graft ; Behavior ; Parkinson's disease ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fetal substantia nigra (SN) cells were transplanted into the caudate nucleus (CN) of four vervet monkeys (Cercopithecus aethiops sabaeus) that had been treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP treatment appears to produce a syndrome similar to that observed in patients with idiopathic Parkinson's disease. Normal and parkinsonian behaviors were quantitated by trained observers 5 days/week. Twenty-eight behaviors based on previous factor analyses were individually scored and rated. Parkinsonian signs included freezing, head and limb tremor, difficulty in eating, delayed initiation of movement, poverty of movement, tremor that stopped with intention, decreased response to threats, and lying immobile in the cage. These signs were combined to give an overall rating of parkinsonism. A summary measure of ‘normal’ healthy behavior was also examined, including such behaviors as yawning, scratching, self-grooming, shifting, and eating. Overall ratings of parkinsonism increased and those of healthy behavior decreased after MPTP. In the 4 monkeys grafted with fetal SN cells into the CN, behavior returned to pre-treatment levels by the time of sacrifice (2, 5, or 7.5 months after grafting). Three control subjects were transplanted with either SN cells into an inappropriate brain site (cortex) or inappropriate, non-dopaminergic, cells (cerebellar) into the CN. Subjects were also compared with three control animals that did not receive MPTP but received cryopreserved or fresh SN and other cells into the CN. Only MPTP-treated subjects that received SN cells into the CN showed evidence of a reversal of the MPTP syndrome after transplantation. In addition, grafting in animals that were not MPTP-treated did not appear to affect behavior. This paper reports the specific behavioral effects of severe MPTP toxicity that were or were not reversed after transplantation and suggests that only fetal SN cells grafted into the CN may be able to reverse behavioral deficits in MPTP-treated monkeys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229411
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  • 9
    Electronic Resource
    Electronic Resource
    Lumbar facet joint fat pads: their normal anatomy and their appearance when enlarged (1991)
    Springer
    Neuroradiology 33 (1991), S. 38-42 
    Details
    ISSN: 1432-1920
    Keywords: Facet joints ; Lumbar spine ; Joint inclusions ; Fat pads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The polar recesses, superior and inferior to lumbar facet joints, are filled by fat pads from which fatfilled synovial folds project between the articular surfaces for a distance of two to four millimetres. The intracapsular superior recess lies between the ligamentum flavum and the lamina above. The extracapsular inferior recess lies on the back of the lamina below and communicates with the joint through a hole in the inferior capsule. The intracapsular folds move freely in and out of the joint during movements. These features are demonstrated in anatomic studies using transverse sections and radiologic studies using computed tomography. In about 4% of lumbar spines examined, the intraarticular fat pads are enlarged and extend from the joint recess(es) into the middle third of one or more facet joints. The fat pads can be identified in CT scans by their radiolucency and distinguished from vacuum phenomenon by measuring their attenuation values. The cause of the intra-articular enlargement of the fat pads is unknown, but it is suggested that their extension into the middle third of the joint may be secondary to degenerative change in the motion segment with capsular laxity in the affected joint.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593331
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  • 10
    Electronic Resource
    Electronic Resource
    Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats (1991)
    Springer
    Psychopharmacology 103 (1991), S. 407-414 
    Details
    ISSN: 1432-2072
    Keywords: Yohimbine ; Morphine ; Naloxone ; Withdrawal ; Tail flick latency ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Noradrenergic neuronal hyperactivity following chronic morphine administration has been postulated to cause withdrawal signs and symptoms. Suppression of this hyperactivity, for example, by clonidine attenuates withdrawal. It might follow, therefore, that the prevention of suppression of noradrenergic systems during chronic morphine administration might diminish hyperactivity and prevent withdrawal. If the normalization of noradrenergic activity during opioid administration did not also suppress analgesia, it might be of medical and theoretical interest. To test this hypothesis, we gave the alpha-2-antagonist yohimbine to rats in order to increase noradrenergic activity during morphine treatment and then subsequently precipitated morphine withdrawal with naloxone. Six groups were examined: saline controls (N=11), morphine (N=11), morphine + 2.0 mg/kg/day yohimbine (N=15), morphine + 3.0 mg/kg/day yohimbine (N=5), 2.0 mg/kg/day yohimbine (N=11) and 3.0 mg/kg/day yohimbine (N=5). Subjects received 75 mg morphine pellets implanted on day 1,4 and 6 of the treatment or sham implantation. Yohimbine was delivered throughout the morphine treatment by subcutaneously implanted osmotic pumps. On day 7, all subjects were given 1.0 mg/kg naloxone and rated for behavioral signs of withdrawal. Analgesia was measured by observing tail flick latencies (TFL) before and after chronic drug treatments. Naloxone-precipitated withdrawal was characterized by irritability, ptosis, penile erection, diarrhea, rhinorrhea, abnormal posture, wetdog shakes, jumping, and teeth chattering, none of which were observed in groups receiving only saline or yohimbine. Withdrawal behavior was attenuated in a dose-dependent manner when yohimbine was administered during morphine treatment but analgesia was not attenuated. It appears that yohimbine-induced antagonism of alpha-2-adrenergic receptors diminishes the development of the potential for adrenergic hyperactivity and morphine withdrawal without reducing opioid analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244297
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