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  • 1
    ISSN: 1420-908X
    Keywords: Tumour necrosis factorα ; Interleukin-1β ; Myeloperoxidase ; Tissue-chamber (mouse) ; Inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A tissue-chamber model of inflammation in mice has been modified and used to investigate the kinetics of zymosan-induced inflammatory mediators such as tumour necrosis factorα (TNFα), interleukin-1β (IL-1β) and prostaglandin E2 (PGE2). In addition, the influx of polymorphonuclear leukocytes (PMN) into the chamber fluid and the granuloma surrounding the chamber was measured by myeloperoxidase (MPO) activity using a new microtitre plate assay. TNFα and IL-1β reached peak concentrations at 3 and 6 h respectively after zymosan injection. Intermediate high concentrations of IL-1β were observed until the end of the experiment at 72 h, but TNFα concentrations decreased from 24 h to biologically insignificant values. In contrast, exudate PGE2 and MPO activity increased up to 24 h after zymosan injection and remained high until 72 h. At 6h after zymosan challenge, oral pre-treatment with prednisolone (3 to 30mg/kg) dose-dependently reduced TNFα, IL-1β and PGE2 concentrations while indomethacin (0.3 to 3 mg/kg) significantly attenuated PGE2, slightly enhanced TNFα and had no effect on IL-1β concentrations in the exudate. Both drugs had similar potencies against exudate and tissue MPO activities. Prednisolone inhibited IL-1β at 72 h post-zymosan. Indomethacin was more potent than prednisolone against PGE2 (ID50 of 〈0.3 versus 0.6mg/kg). The data obtained confirm the usefulness and reliability of this model in evaluating the effects of anti-inflammatory agents on inflammatory mediators induced by zymosan.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 158 (1999), S. 1012-1012 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The heme-containing dehaloperoxidase from Amphitrite ornata was crystallized from an unbuffered solution containing 30% PEG 8000 and 200 mM ammonium sulfate by the hanging-drop vapor-diffusion method. Dark-red bipyramidal crystals are orthorhombic in space group P212121 with unit-cell dimensions a = 68.5, b = 68.4 and c = 61.1 Å. The asymmetric unit contains two subunits related by a non-crystallographic twofold axis. The crystals scatter beyond 2 Å resolution. The native data have been collected and one single-site mercury derivative has been found. SIRAS phasing was used to determine the positions of the heme Fe atoms and structure determination is in progress. A preliminary spectroscopic investigation indicates that the heme is protoporphyrin IX and its coordination sphere resembles that of a typical heme peroxidase, i.e. histidine ligated. Detailed spectroscopic and electrochemical studies are now under way.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Activities of enzyme markers of subcellular organelles have been measured in brain tissue from subjects with Alzheimer-type dementia (ATD) and Huntington's disease (HD). Significant increases in the activity of the lysosomal enzyme β-glucuronidase were observed in both ATD temporal cortex and HD putamen. It is suggested that β-glucuronidase activity may be a useful biochemical indicator of cellular damage in the CNS. A significant reduction in neutral α-glucosidase activity was observed in ATD temporal cortex and HD putamen. This change may reflect an alteration in glycoconjugate processing and may relate to the susceptibility of neurones to the degenerative processes of ATD and HD.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Inc
    Journal of metamorphic geology 15 (1997), S. 0 
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Ultrahigh-temperature quartz-sapphirine granulite xenoliths in the post-Karoo Lace kimberlite, South Africa, comprise mainly quartz, sapphirine, garnet and sillimanite, with rarer orthopyroxene, antiperthite, corundum and zinc-bearing spinel; constant accessories are rutile, graphite and sulphides. Comparison with assemblages in the experimentally determined FMAS and KFMASH grids indicates initial equilibration at 〉1040 °C and 9–11 kbar. Corona assemblages involving garnet, sillimanite and minor cordierite developed on a near-isobaric cooling P–T  path as both temperature and, to a lesser extent, pressures decreased. Garnet-orthopyroxene Fe-Mg exchange thermometers record temperatures of only 830–916 °C. These estimates do not indicate the peak metamorphic conditions but instead reflect the importance of post-peak Fe-Mg exchange during cooling. Correction of mineral Fe-Mg compositions for this exhange using a convergence approach of Fitzsimons & Harley (1994) leads to retrieved P–T  estimates from garnet-orthopyroxene thermobarometry (c. 1000 °C and 10.5±0.7 kbar) that are consistent with the petrogenetic grid constraints. U-Pb dating of a single zircon grain gives an age of 2590±83 Ma, interpreted as the age of the metamorphic event. Protolith major and trace element chemistries of the xenoliths differ from sapphirine-quartzites typical of the Napier Complex (Antarctica) but are comparable to less siliceous, high Cr and Ni, sapphirine granulites reported from several ultrahigh temperature granulite terranes.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Using x-ray diffraction techniques, we measure the root-mean-square width of the buried crystalline/amorphous Si(001)/SiO2 interface, as a function of oxide thickness. We find that the interface width decreases with increasing oxide thickness; the oxide growth process kinetically smoothens the buried interface. We also find a difference between the rate of smoothing for wet and dry oxides. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Electric Tokamak (ET), currently under construction at the University of California–Los Angeles, is designed to rotate poloidally via a radial current induced by fast wave rf heating fast enough to bifurcate the plasma into a global "H mode" ("high confinement mode"). A global gyrokinetic code is used to explore and illustrate some of the effects on ion temperature gradient turbulence. The realistic radial electric field required to completely suppress these modes for ET parameters is demonstrated to be 〈−30 V/cm at its maximum near the half radius. The effects of both a poloidally supersonic bulk rotation threshold and the shear in this rotation near that supersonic threshold were shown to be important in reducing these modes. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 516-526 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper numerical solutions of Zakharov-type equations for lower-hybrid (LH) waves, including pumping at the long wavelengths and dissipation at short wavelengths in the form of dissipative cavitons are described. The caviton is a quasistationary structure undergoing many sequences of collapse due to dissipation, created by ion–wave interactions, which is compensated for by constant pump action. The possibility of trapping of short-wavelength LH oscillations by much broader density cavitons is investigated both analytically and numerically. Analytic self-similar solutions corresponding to collapse of such cavitons are constructed and demonstrate cascading to shorter wavelengths, which develops faster than the three-dimensional (3-D) quasiclassical cavity contraction. Numerical solutions show the development of deep caviton modulation due to the instability of quasiclassical collapse. Results of the numerical and analytical investigation are used to explain the recent observations of cavity formation in the auroral ionosphere, and show that the measured structures could indeed arise from quasiclassical LH collapse. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 1767-1788 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Particle dynamics and field behavior associated with a perpendicular collisionless supercritical and viscous shock are investigated by use of numerical simulation. A one-dimensional, relativistic, fully electromagnetic and nonperiodic particle simulation code (for both electrons and ions) is used where self-consistent space-charge effects and induced effects are totally included. The principal field patterns of the shock (trailing wave train, ramp, and foot region) are studied in detail and are shown to have scale lengths mainly dictated by ion dynamics; the behavior of the corresponding plasma currents associated with the different field components is also presented. Ions are shown to suffer successive "acceleration–trapping–detrapping'' at the shock front, and locally in the trailing wave train of the downstream region through combined effects of the electrostatic and magnetic fields. While detrapped, the reflected ions describe very large Larmor orbits and cause a ring distribution; a large rapid nonstochastic ion heating results from this ion gyration. This heating (resistivity-free) is the main source of dissipation and is responsible for large field damping. Competitive effects such as particle stochasticity, particle trapping, wave damping, wave overtaking, and dispersion effects are shown to interact with each other and to affect the overall dissipation mechanism. Comparison with previous works is also discussed. Various Mach number situations are considered, leading to the definition of a transitory regime between subcritical and supercritical regimes and of a corresponding critical threshold of the electrostatic field. In contrast with the supercritical regime, the subcritical regime is characterized by a low density of trapped-reflected ions, a broad ion distribution function with a weak tail, and a weak adiabatic bulk ion heating.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 29 (1986), S. 821-836 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The behavior of strong magnetosonic waves propagating perpendicular to a static field B0 is investigated within the frequency range ωci〈ω〈ωlh; ωci,ω, and ωlh are, respectively, the ion cyclotron, the pump wave, and the lower-hybrid frequencies. A one-dimensional, relativistic, fully electromagnetic, particle simulation code (for both electrons and ions) is used, where self-consistent effects are totally included. During the buildup phase, a longitudinal electric field develops and attains a nonlinear level which strongly distorts its shape so that many harmonics are produced. This is followed shortly by ion trapping, which simultaneously enhances the wave overtaking (the wave crests overtaking the wave troughs) and produced a strong wave damping. A very large ion acceleration accompanied by a strong heating (mainly nonstochastic) perpendicular to B0 results; the electrons exhibit only poor heating associated with their adiabatic compression. The dynamics of both particle species, the consequences of the wave–particle energy transfer and the particle viscosities, are studied in detail. Competitive and self-consistent effects such as space-charge effects, wave overtaking, ion trapping, and wave damping are investigated and compared with previous models; the mechanisms by which these various phenomena interact on each other are analyzed. Characteristics of nonstochastic and stochastic ion heating are also discussed. Our computations show that if sufficient intensity is reached, one is not constrained to use lower-hybrid waves or cyclotron harmonic waves to heat a plasma efficiently and that any frequency below ωlh can be used.
    Type of Medium: Electronic Resource
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