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  • 1
    Electronic Resource
    Electronic Resource
    Identification of a uninucleate Rhizoctonia sp. by pathogenicity, hyphal anastomosis and RAPD analysis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 45 (1996), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Finnish and Norwegian uninucleate Rhizoctonia sp, isolates. originating from roots of nursery grown conifer seedlings suffering from root dieback, and having Ceratobasidium perfect state, were tested for pathogenicity and genetic related ness. All tested isolates of this pathogen considerably reduced the root system development of Scots pine and Norway spruce seedlings resulting in death or stunted growth. The uninucleate isolates anastomosed readily with each other producing a killing reaction. In a RAPD-PCR analysis, the uninucleate isolates had different banding patterns from our reference isolates, two Finnish binucleate isolates (AG-I and R. sp.) and standard tester isolates of genus Ceratobasidium representing anastomosis groups AG-A, AG-C, AG-E, AG-G and AG-I. UPGMA analysis clustered the uninucleate isolates together at a greater similarity than 75% while the binucleate isolates formed distinct clusters and were 10-25% similar to the uninucleate Rhizoctonia sp. Hyphal anastomosis and DNA data suggest that the uninucleate Rhizocionia sp. is an homogeneous group and distinct from the tested binucleate Rhizoctonia isolates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1996.tb02912.x
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  • 2
    Electronic Resource
    Electronic Resource
    The normal pituitary examined with positron emission tomography and (methyl-11C)-L-methionine and (methyl-11C)-D-methionine (1987)
    Springer
    Neuroradiology 29 (1987), S. 221-225 
    Details
    ISSN: 1432-1920
    Keywords: Positron emission tomography ; Brain metabolism ; Amino acids ; Stereospecificity ; Pituitary gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (methyl-11C)-L-methionine. On a following day the examination was repeated with (methyl-11c)-D-methionine. The accumulation rate of L-methionine in the pituitary was measured, giving a value that was about twice that of normal brain tissue. The accumulation rate of D-methionine in the pituitary was almost a factor of 10 lower than that of L-methionine. In the normal brain tissue that ratio was 2.3. The study clearly indicates that the methionine uptake in the pituitary is stereospecific. 11C-D-methionine is freely distributed in the tissue without entrapment, whereas 11C-L-methionine is irreversibly bound. It is concluded that PET with 11C-L-methionine can be used to study amino acid utilization in the pituitary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451757
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Stereotactic Irradiation of Skull Base Meningiomas with High Energy Protons (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 933-940 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Stereotactic irradiation; meningioma; MRI; proton beam therapy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Nineteen patients with inextirpable skull base meningioma with involvement of neurovascular structures were given irradiation with a 180 MeV proton beam at the The Svedberg Laboratory, Uppsala, Sweden. The patients were treated seated in a fixed position with a stereotactic approach. Titanium-markers to the outer table served for identification and verification of the target positioning for dose planning and irradiation. The patients were given a total dose of 24 Gy in four consecutive daily 6 Gy fractions. All patients have been followed for at least 36 months. So far no meningiomas have progressed after treatment. Two patients have developed corticosteroid responsive oedema in the target area 6 moths after treatment. Late, but not serious, symptoms of side effects have been observed in one patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050399
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  • 4
    Electronic Resource
    Electronic Resource
    Activation PET scanning in pretreatment evaluation of patients with cerebral tumours or vascular lesions in or close to the sensorimotor cortex (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 684-694 
    Details
    ISSN: 0942-0940
    Keywords: Brain mapping ; positron emission tomography ; brain neoplasm ; cerebrovascular malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Treatment of tumours and vascular lesions in or close to eloquent cortex may inflict neurological deficits. Intra-operative mapping procedures have been used for many decades in efforts to minimize neurological sequelae. The possibility for non-invasive preoperative brain mapping has emerged with the advent of positron emission tomography (PET). In this paper we report on 11 patients with a tumour or vascular lesion in or close to the sensorimotor (10 patients) or visual cortex (one patient). The patients were subjected to activation PET scanning by means of vibrotactile or visual stimulation. The results show that in most of the patients the important relation between the lesion and the sensorimotor cortex could be determined. The patient with a lesion in the occipital lobe had involvement of the entire visual cortex as judged by comparison with activated areas on the nonlesion side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411473
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey (1995)
    Springer
    Journal of neural transmission 102 (1995), S. 189-208 
    Details
    ISSN: 1435-1463
    Keywords: Tetrahydrobiopterin ; muscarinic cholinergic receptor ; dopamine D1, D2, D3 receptors ; positron emission tomography ; monkey brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the Rhesus monkey brain were investigated by positron emission tomography (PET) with the muscarinic cholinergic receptor ligands (N-[11C]methyl-benztropine) and dopaminergic receptor ligands selective for D1 D2, and D3 subtypes ([11C]SCH23390, N-[11C]methyl-spiperone, and (+)[11C]UH232, respectively). None of the doses (3, 10, and 30 mg/kg i.v.) of R-THBP used significantly affected the regional cerebral blood flow (rCBF as determined by Raichle's H2 15O method), and 10 mg/kg of R-THBP had little effect on the regional cerebral metabolic rate of glucose (rCMRglc) in the Rhesus monkey brain, as assessed by the graphical [18F]fluoro-deoxyglucose method. The effect of R-THBP on the muscarinic cholinergic system was dose dependent; while 3 mg/kg of R-THBP did not significantly alter the uptake ratio of N-[11C]methyl-benztropine in several brain regions to that in the cerebellum, 10 and 30 mg/kg of R-THBP significantly reduced the uptake ratio in the thalamus, as well as in the frontal and temporal cortices. None of the doses (3, 10, and 30 mg/kg i.v.) of R-THBP tested affected [11C]SCH23390 (dopamine D1 receptor) binding. However, the k3 value for N-[11C]methyl-spiperone (dopamine D2 receptor) binding, which represents the association rate × Bmax value, was significantly decreased in the striatum. The uptake ratio of (+)[11C]UH232 (dopamine D3 receptor) in the striatum to that in the cerebellum was also decreased by administration of R-THBP (3 and 30 mg/kg i.v.). These findings suggest that R-THBP acts on dopamine D2 and D3 receptors selectively without markedly affecting dopamine D1 receptor binding. Furthermore, the changes in cholinergic and dopamine D2 and D3 receptors in vivo can not be attributed to a change in rCBF but may depend on the action of R-THBP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01281154
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