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  • 1
    Electronic Resource
    Electronic Resource
    Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia (1996)
    [s.l.] : Nature Publishing Group
    Nature genetics 12 (1996), S. 448-451 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Targeting of the replacement vector (pExon8−) led to the deletion of Fac exon 8 and insertion of the neo gene after homologous recombination (Fig. 1a,b). Homozygous mice were produced by breeding offspring of the chimaeras (Fig. 1c). RT-PCR analysis demonstrated that exon 8 was absent from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0496-448
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  • 2
    Electronic Resource
    Electronic Resource
    Differential Effect of NMDA on Extracellular Serotonin in Rat Midbrain Raphe and Forebrain Sites (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The contribution of NMDA receptors to regulation of serotonin (5-HT) release was assessed by in vivo microdialysis in freely behaving rats. During infusion of NMDA (30, 100, and 300 µM) into the dorsal raphe nucleus (DRN), 5-HT was increased by ∼25, 100, and 280%, respectively. Competitive and noncompetitive NMDA-receptor antagonists blocked this effect on DRN 5-HT. Infusion of NMDA (300 µM) into the DRN also produced an 80% increase in extracellular 5-HT in the nucleus accumbens. During infusion of NMDA (100 and 300 µM) into the median raphe nucleus (MRN), 5-HT was increased by ∼15 and 80%, respectively. NMDA-receptor antagonists blocked this effect on MRN 5-HT. Infusion of NMDA into the MRN also produced a significant increase in hippocampal 5-HT. In contrast, infusion of NMDA into the nucleus accumbens, frontal cortex, or hippocampus produced small decreases in 5-HT in these forebrain sites. Taken together, these results suggest that NMDA receptors in the midbrain raphe, but not the forebrain, can have an excitatory influence on 5-HT neurons and, thus, produce increased 5-HT release in the forebrain. Furthermore, in comparison with the MRN, DRN 5-HT neurons were more sensitive to the excitatory effect of NMDA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66031067.x
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  • 3
    Electronic Resource
    Electronic Resource
    Modeling orientational randomization in zeolites: A new probe of intracage mobility, diffusion and cation disorder (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 2893-2905 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have performed kinetic Monte Carlo simulations of benzene orientational randomization (BOR) and diffusion in Na-Y zeolite for various Na(II) occupancies and Na(II) spatial patterns. Full Na(II) occupancy gives BOR rates controlled by intracage motion, whereas half Na(II) occupancy gives BOR rates sensitive to both intracage and intercage motion, but insensitive to particular Na(II) spatial patterns. Alternatively, BOR with one quarter Na(II) occupancy demonstrates qualitative sensitivity to different Na(II) spatial patterns. Calculated diffusion coefficients vary weakly with decreasing Na(II) occupancy until ca. one Na(II) per supercage. Diffusion coefficients and mean square displacements reveal no information about intracage motion, and are insensitive to different spatial patterns of Na(II) cations. Our computational results thus suggest that measuring orientational randomization in zeolites can provide important information regarding intracage motion, diffusion and cation disorder. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473352
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  • 4
    Electronic Resource
    Electronic Resource
    Analytical theory of benzene diffusion in Na-Y zeolite (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 7810-7815 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have developed an analytical expression for the diffusion coefficient of benzene in Na-Y at infinite dilution in terms of fundamental rate coefficients, which has been confirmed by extensive kinetic Monte Carlo simulations. This model assumes that benzene jumps among SII and W binding sites, located near Na+ ions in 6-rings and in 12-ring windows, respectively. Our diffusion theory is based on D=〈fraction SHAPE="CASE"〉16ka2 where a≅11 Å is the intercage length and k is the cage-to-cage rate coefficient. We have determined that k=k(SII→W)⋅〈fraction SHAPE="CASE"〉12⋅3[1+k(W→W)/k(W→SII)], a finding that has resolved discrepancies between theory and simulation and has suggested new interpretations of benzene diffusion in Na-Y. When α(T)≡k(W→W)/k(W→SII) is between 0 and 1, the factor 3[1+α(T)] counts the number of thermally allowed target sites for cage-to-cage motion. Alternatively, when α(T)(very-much-greater-than)1, benzene mobility is interpreted as interstitial diffusion, wherein k is controlled by the probability of W site occupancy multiplied by the rate of W→W jump processes. This limit is expected to arise with benzene loadings of four molecules per supercage. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473738
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  • 5
    Electronic Resource
    Electronic Resource
    Transport Theory for Cationic Zeolites: Diffusion of Benzene in Na-Y (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 10600-10608 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100026a025
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  • 6
    Electronic Resource
    Electronic Resource
    Alignment of D2(v, J) desorbed from Cu(111): Low sensitivity of activated dissociative chemisorption to approach geometry (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 9702-9705 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have determined the alignment of D2(v,J) desorbed from Cu(111). The measurements reveal a small preference for "helicoptering'' motion that increases with increasing J. At low J, the alignments are much smaller than predicted by recent calculations. We believe that the anisotropic potential may scramble the alignment as the molecules leave the surface. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472979
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  • 7
    Electronic Resource
    Electronic Resource
    [3H]Choline Uptake and Metabolism in Nonsynaptic Regions of a Crustacean Sensory Nerve (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 36 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The posterior stomach nerve (PSN) is a crustacean sensory nerve containing about 60 cholinergic neurons, which are devoid of synaptic interactions. Kinetic analysis shows that the PSN takes up [3H]choline by both low-affinity (Km= 163 μM) and high-affinity (Na+-dependent) (Km= 1 μM) processes. The capacity of the high-affinity system is only about 1% that of the low-affinity system. The high-affinity system is not tightly coupled to acetylcholine (ACh) synthesis, and it appears that both ACh and phosphorylcholine are formed from an intracellular pool of choline, which is fed by both uptake systems. There are differences in the rates of [3H]choline uptake and 3H metabolite accumulation between regions of the PSN that contain neuronal cell bodies and those that do not. These differences may arise from differences in the relative proportion of neuronal to nonneuronal tissue in each nerve region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb00415.x
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  • 8
    Electronic Resource
    Electronic Resource
    Breastfeeding (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of obstetric, gynecologic and neonatal nursing 24 (1995), S. 0 
    Details
    ISSN: 1552-6909
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1552-6909.1995.tb02476.x
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  • 9
    Electronic Resource
    Electronic Resource
    Art, Advertising, and the Legacy of Empire (2002)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of popular culture 35 (2002), S. 0 
    Details
    ISSN: 1540-5931
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Ethnic Sciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-3840.2002.3504_1.x
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  • 10
    Electronic Resource
    Electronic Resource
    Dynamics of the formation of CD4 from the direct reaction of incident D atoms with CD3/Cu(111) (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 10115-10122 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Using molecular beam techniques we find that incident D atoms can abstract CD3 from a Cu(111) surface to yield CD4 in a direct (Eley–Rideal) gas–surface reaction with a cross section of ∼10−16 cm2/D atom. Dynamical evidence for a direct reaction includes the observation of an extremely sharp angular distribution that is clearly displaced from the surface normal, and the determination of a very high translational energy of the product, Ef, which is ∼2 eV. For a 0.25 eV D-atom beam incident at 45° on a 95 K surface, this energy varies with the detection angle, θf, as Ef(θf)=(1.8+θf/45) eV, where θf〈0° in the "backscattering'' direction. For these conditions, the angular distribution approximately follows the function cos70(θf−5.5), being peaked 5.5° from the normal with a full width at half maximum of 〈17°. Lowering the beam energy to 0.07 eV gives a broader angular distribution peaked at about 1.5° from the normal, consistent with cos60(θf−1.5). The reaction with 0.25 eV H incident at 45° gives a similar distribution peaked at ∼3.5° from the normal. The shifts in the angular distributions are approximately consistent with parallel momentum conservation. The CD3/Cu(111) surface was prepared by thermal dissociation of CD3I on the surface or by adsorbing CD3 directly from a CD3 beam produced by the pyrolysis of azomethane. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472840
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