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  • 1995-1999  (5)
  • 1975-1979  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 3 (1998), S. 0 
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study evaluates the quality of life status of 39 male and 21 female Caucasian subjects admitted to a voluntary sector community alcohol detoxification unit. Baseline data including socio-demographics, severity of alcohol dependence and alcohol problems were collected 4–5 days following admission. In addition, the following measures were obtained: Rotterdam Symptoms Checklist, the Beck Depression Inventory, the General Health Questionnaire 12, Chubon's Life Situation Survey and the Nottingham Health Profile. Subjects were followed up at 12 weeks, and subdivided into two groups: relapsers and non-relapsers. A relapse was defined as drinking 21 or more units per week for men and 14 units or more per week for women over 7 consecutive days (1 unit is the equivalent of 8–10 g of absolute ethanol). Fifty-eight (97%) subjects were successfully followed-up, with 36 (62%) of the group relapsing to heavy drinking within 12 weeks. The results show that alcohol dependence is associated with a poor quality of life. Subjects rated poorly on the standardized questionnaires compared with the normative values for their reference populations. Relapsers and non-relapsers differed significantly in their life situation, depression, physical and psychological symptom total scores and the Nottingham Health Profile sub-score energy at 12 weeks compared with baseline, and these changes were investigated for each group. Within the relapse group a linear regression showed no association between any of the quality of life measures and time to relapse. Individual sub-score analysis of the Nottingham Health Profile results point to the importance of sleep, social isolation, pain, physical mobility and anergia in alcohol dependency. There was little change as a result of either not remitting or returning to heavy drinking and overall these findings confirm that alcohol dependent subjects have a poor quality of life.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The effects of repeated point contact loading of a toughened ceria-stabilised zirconia ceramic, CeTZP, by softer metallic cones, have been investigated. All tests were conducted on a purpose-designed and built computer-controlled apparatus. The results clearly indicate that zirconia is susceptible to cyclic loading. The evolution of the cyclic deformation and cracking processes have been analysed in terms of contact pressures, applied loading conditions and number of cycles. The ground tips of both quenched, and quenched and tempered, silver steel cones are plastically deformed during the initial loading cycle to produce a conforming planar surface approximately 50-100 μm in diameter. In all cases, plastic deformation in the CeTZP was observed within, and adjacent to, the contact zones. The degree of plastic deformation increased as the number of cycles increased. The expansion associated with the tetragonal-to-martensitic phase transformation in the zirconia caused granular lifting from the surface, at the edge of the contact zone. This resulted in localised spalling at the peripheries of the contact zones, where the tensile stresses are the highest, followed by a radial expansion at higher cycle numbers. This investigation has identified that the rate of evolution of the fatigue damage, in decreasing order of significance, was controlled by: (a) cone hardness, (b) cyclic load amplitude and (c) mean load.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 301-303 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We studied 51 healthy boys and girls between the ages of llz and 14 yr; all attended a normal secondary school in Somerset, UK and blood was taken between 1100 and 1300 hr. At the time of sampling each child was assigned to one of five maturity stages11 according to genitalia or breast development. ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1076
    Keywords: Key words Chronic lung disease ; Prematurity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neonatal chronic lung disease (CLD) is usually diagnosed if an infant remains oxygen dependent beyond 36 weeks postconceptional age (PCA). Our aim was to determine whether a shorter duration of respiratory support accurately predicted subsequent respiratory morbidity. A total of 103 infants, median gestational age 29 weeks (range 23–35), were followed prospectively for 5 years. They had a birth weight of 〈1500 g or, if a birth weight of between 1500 and 2000 g, had required neonatal ventilatory support. Parents completed diary cards; their child had positive symptom status if, in any one year, they coughed and/or wheezed on at least 3 days per week for a 4-week period or for at least 3 days following each upper respiratory tract infection. Subsequent respiratory morbidity, positive symptom status in years 1 and 2 or all 5 pre-school years, was related to various definitions of prolonged respiratory support: intermittent positive pressure ventilation dependence 〉7 days; oxygen dependence 〉28 days and oxygen dependence 〉36 weeks PCA. In years 1 and 2, 25 children were symptomatic and 22 in all 5 years. The patients with subsequent respiratory morbidity were distinguished from those without by requiring longer respiratory support (P 〈 0.05). Logistic regression analysis demonstrated only oxygen dependence beyond 28 days was independently related to subsequent respiratory morbidity (P 〈 0.01). The positive predictive values and likelihood ratios (95% confidence intervals) for positive symptom status in all 5 years were for intermittent positive pressure ventilation 〉7 days 35% (16–53) and 19.5 (1.01–3.76), for oxygen dependency 〉28 days 42% (23–61) and 2.20 (1.45–5.02) and for oxygen dependency 〉36 weeks PCA 35% (13–58) and 1.67 (0.65–4.31). Conclusion Oxygen dependency at 28 days of age remains a useful criterion on which to diagnose “neonatal” chronic lung disease.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Key words Fluid balance ; Lung function ; Very low birthweight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fluid overload worsens respiratory failure; conversely, fluid restriction has been associated with a higher survival rate without chronic lung disease. We therefore hypothesised that fluid restriction in the perinatal period might improve lung function in ventilated, prematurely born infants of very low birthweight. As a consequence, we compared in a randomised trial the effect of two fluid regimes on perinatal lung function. On one regime infants were to receive 60 ml/kg on day 1, increasing to 150 ml/kg by day 7, and on the other regime approximately 25% less fluid was to be prescribed. Lung function was assessed by measurement of functional residual capacity (FRC) and compliance. Measurements were made daily on days 1 to 5 and then on day 7. Ninety infants, median gestational age 28 weeks (range 23–33), were included in the study. There were no significant differences between the two groups regarding their gestational age or birthweight, or in the proportions who received antenatal steroids or postnatal surfactant. The infants on the restricted regime received significantly less fluid (P 〈 0.01). The only significant differences in lung function between the two groups, however, were that the infants on the restricted regime had a higher mean compliance on day 3, but thereafter the difference was reversed. Colloid intake, however, unfavourably affected lung function, total colloid intake being negatively correlated with both the area under the curve of birth-adjusted FRC (P=0.003) and compliance (P=0.001). Conclusion We conclude that early fluid restriction appears to have very little impact on perinatal lung function.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 10 (1978), S. 279-282 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 10 (1978), S. 293-300 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract The effects of photodiode bulk leakage current and amplifier noise on receiver sensitivity are analysed using a model described previously [4]. The sensitivity of a receiver using a PIN photodiode can be greatly improved by employing a high-performance microwave FET in the input stage, to the point where its remaining technical disadvantage in comparison with a silicon APD receiver at 800–900 nm may be offset by economic and operational attractions. In systems operating at the optimum transmission wavelength beyond 1.1 μm, the PIN-FET hybrid receiver may offer better technical performance than an APD receiver.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 30 (1995), S. 151-161 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract An investigation has been conducted to study the fatigue deformation and fracture induced by pressing 120° hardened silver steel conical tips against a flat, polished CeTZP counterface between 293 and 1073 K with cyclic loads of 19.6±9.8 N, for up to 475 000 cycles. The ground tips of the cones plastically deformed during the initial loading cycle to produce a flattened end which conformed with the substrate. This test format has been devised to be comparable to the service conditions that these types of ceramics are likely to experience. At temperatures up to, and including, 673 K, the sequence of events is that a tetragonal to monoclinic transformed zone is formed around the contact zone. This expands as the number of cycles is increased. Much later in the fatigue process, grain lifting occurs at the periphery of the contact zone. This subsequently causes intergranular pitting to progress around the edge of the contact zone followed by extension both away from and into the contact region. At 673 K and above, a small number (3–5) of radial intergranular cracks are formed after a few cycles (≤10) which propagate a substantial distance away from the contact zone.
    Type of Medium: Electronic Resource
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