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  • 1
    Electronic Resource
    Electronic Resource
    Velocity statistics in excited granular media (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Chaos 9 (1999), S. 682-690 
    Details
    ISSN: 1089-7682
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present an experimental study of velocity statistics for a partial layer of inelastic colliding beads driven by a vertically oscillating boundary. Over a wide range of parameters (accelerations 3–8 times the gravitational acceleration), the probability distribution P(v) deviates measurably from a Gaussian for the two horizontal velocity components. It can be described by P(v)∼exp(−|v/vc|1.5), in agreement with a recent theory. The characteristic velocity vc is proportional to the peak velocity of the boundary. The granular temperature, defined as the mean square particle velocity, varies with particle density and exhibits a maximum at intermediate densities. On the other hand, for free cooling in the absence of excitation, we find an exponential velocity distribution. Finally, we examine the sharing of energy between particles of different mass. The more massive particles are found to have greater kinetic energy. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.166442
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  • 2
    Electronic Resource
    Electronic Resource
    HLA-G deletion polymorphism and pre-eclampsia/eclampsia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.Design A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.Setting Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.Subjects One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.Results Genotypic and gene frequencies were not significantly different in the seven groups examined.Conclusion There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb11427.x
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  • 3
    Electronic Resource
    Electronic Resource
    Alzheimer’s Disease (1999)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Peptide aldehyde inhibitors of the chymotrypsin-like activity of the proteasome (CLIP) such as N-acetyl-Leu-Leu-Nle-H (or ALLN) have been shown previously to inhibit the secretion of β-amyloid peptide (Aβ) from cells. To evaluate more fully the role of the proteasome in this process, we have tested the effects on Aβ formation of a much wider range of peptide-based inhibitors of CLIP than published previously. The inhibitors tested included several peptide boronates, some of which proved to be the most potent peptide-based inhibitors of β-amyloid production reported so far. We found that the ability of the peptide aldehyde and boronate inhibitors to suppress Aβ formation from cells correlated extremely well with their potency as CLIP inhibitors. Thus, we conclude that the proteasome may be involved either directly or indirectly in Aβ formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730195.x
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of Potential Parameters for Gas-Solid Interactions from Quantum Effects in Physical Adsorption (1965)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 69 (1965), S. 1768-1770 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100889a517
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  • 5
    Electronic Resource
    Electronic Resource
    Collective Responsibility (1968)
    Cambridge : Cambridge University Press
    Philosophy 43 (1968), S. 258-268 
    Details
    ISSN: 0031-8191
    Source: Cambridge Journals Digital Archives
    Topics: Philosophy
    Notes: Philosophers constantly discuss Responsibility. Yet in every discussion of which I am aware, a rather obvious point is ignored. The obvious point is that responsibility is ascribed to collectives, as well as to individual persons. Blaming attitudes are held towards collectives as well as towards individuals. (It should be noted that I am discussing that sense of Responsibility—moral or social—in which Responsibility is related to attitudes of blame, praise, indignation, remorse, reward, and punishment; not that sense of Responsibility in which even material objects can be responsible, and which is broadly equivalent to ‘causally operative’.) Responsibility is often ascribed to nations, towns, clubs, groups, teams, and married couples. ‘Germany was responsible for the Second World War’; ‘The club as a whole is to blame for being relegated’. Such statements are not rare.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0031819100009220
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  • 6
    Electronic Resource
    Electronic Resource
    Safety and effect of transforming growth factor-β2 for treatment of venous stasis ulcers (1995)
    Oxford, UK : Blackwell Science
    Wound repair and regeneration 3 (1995), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Transforming growth factor-β2 promotes healing in a variety of animal models and exhibits clinical effects thought to be mediated by connective tissue formation. Two clinical trials were conducted to evaluate the safety and effect of transforming growth factor-β2 purified from bovine bone and delivered topically to venous stasis ulcers three times per week for up to 6 weeks by means of a lyophilized collagen vehicle. The first was an open-label trial comparing transforming growth factor-β2 purified from bovine bone (0.5 µg/cm2) with a placebo consisting of lyophilized collagen vehicle-without active drug. After no safety issues arose in that trial, a prospectively randomized, closed-label, observer-blinded, three-armed trial was conducted to compare bovine transforming growth factor-β2 (2.5 µg/cm2) with the collagen matrix placebo vehicle and with a standard dressing. Standardized elastic compression was applied to all test extremities. The rate of reduction of ulcer area as measured by planimetry was the primary measure of effect. No serious safety-related events occurred in either trial. Clinical evaluation suggested that improvement in the quality and quantity of granulation tissue appeared to precede epithelialization of ulcers treated with bovine transforming growth factor-β2. In both studies, treatment with bovine transforming growth factor-β2 appeared to have a positive effect on the rate of ulcer closure, whereas ulcers in the control groups continued to exhibit impaired healing. In the open-label study, the mean rate of closure of ulcers treated with bovine transforming growth factor-β2 was significantly greater than that of ulcers treated with placebo. There was likewise enhanced reduction in ulcer area in the ulcers treated with bovine transforming growth factor-β2 in the second trial. However, because of a higher variability in patient response and a greater placebo effect, the difference was not significant. The placebo was not worse than the standard care arm, thereby showing that the vehicle is not injurious to healing. The combined results of the two trials suggest that, at doses of 0.5 to 2.5 µg/cm2, bovine transforming growth factor-β2 is safe as a topically applied agent in a collagen matrix vehicle and can have a positive effect on closure of venous stasis ulcers. Large multicenter trials appear to be indicated to evaluate fully the potential utility of transforming growth factor-β2 in accelerating closure of chronic dermal ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-475X.1995.30207.x
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  • 7
    Electronic Resource
    Electronic Resource
    Toombak-associated oral mucosal lesions in Sudanese show a low prevalence of epithelial dysplasia (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 25 (1996), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clinical (n=281) and histopathological (n=141) characteristics of toombak-associated oral mucosal lesions detected in an epidemiological study in northern Sudan in 1992/93 are described. The lesional site in the majority of toombak users was the anterior lower labial groove and the lower labial mucosa. 4 degrees (1–4) of clinical severity of lesions, similar to those used to characterise Swedish snuff-dipper's lesion, were applied. An association between the severity of mucosal lesions and a longer lifetime duration (〉10 years) of toombak use was found, but the severity was not related to the daily frequency of the habit. Parakeratosis, pale surface staining of the epithelium and basal cell hyperplasia were commonly observed, but epithelial dysplasia was infrequent (10/141). The most significant observation was a PAS-positive amorphous deposit between the lamina propria and the submucosa, found in 25/141 biopsies. The clinical and histopathological features of toombak lesions are closely similar to Swedish moist snuff-dipper's lesions and this may reflect the high alkalinity of these products, resulting in an alkaline burn on the oral mucosa following chronic exposure. The low prevalence of epithelial dysplasia implies a low risk of malignant transformation. Nevertheless, the high concentrations of tobacco-specific nitrosamines present in toombak, and the high prevalence of oral cancer in Sudan, mandate biopsy and careful histopathological analysis of any such lesions detected in habitues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1996.tb01378.x
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  • 8
    Electronic Resource
    Electronic Resource
    How many endomyocardial biopsies are necessary in the first year after heart transplantation? (1996)
    Springer
    Transplant international 9 (1996), S. 243-247 
    Details
    ISSN: 1432-2277
    Keywords: Heart transplantation, endomyocardial biopsy ; Biopsy, endomyocardial ; Endomyocardial biopsy, heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1989, the immunosuppressive regimen used in all heart transplant (HTx) patients at our center has consisted of a combination of cyclosporin, azathioprine, and prednisone. No prophylactic cytolytic agents have been given. One hundred consecutive patients were followed for periods of 4–56 months (mean 27 months). The incidence of rejection was so low in the initial 18 patients that we felt confident about reducing the number of routine endomyocardial biopsies (EMBs) that were performed. The mean number of EMBs in this subgroup was 10 (median 11). In the next 20 patients, EMB was performed routinely on only three occasions during the 1st post-transplant year (at 2, 4, and 8 weeks). In the subsequent 62 patients, EMB was performed on post-transplant days 10, 20, 30, and 60. Further EMBs were performed after acute rejection episodes had been treated. No noninvasive methods of diagnosing rejection were employed. In 82 consecutive patients, therefore, the mean number of EMBs within the 1st year was five per patient (median four), with 58% undergoing fewer than five EMBs and 25% requiring more than five EMBs. In the entire group of 100 patients, the mean number of EMBs was 5.9. The incidence of acute rejection requiring increased therapy was 24%. Only 7% required i.v. steroids, two of whom (2%) also required ALG and/or OKT3, with 17% requiring increased oral immunosuppression alone. Actuarial survival was 98% at 30 days, 94% at 1 year, and 92% at 2 years. It is possible that we may have missed acute rejection episodes that resolved spontaneously. However, the excellent mediumterm results would suggest that any such rejection episode did not progress to become hemodynamically significant. It may be, therefore, that when an effective immunosuppressive regimen is utilized, the number of EMBs performed at many centers is excessive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335393
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure changes associated with brain death in the human donor heart (1996)
    Springer
    Transplant international 10 (1996), S. 24-32 
    Details
    ISSN: 1432-2277
    Keywords: Cardiac donors ; Ultrastructural changes heart, brain death, Triiodothyronine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electromicroscopic examinations were carried out on 30 myocardial biopsies taken from 22 human donor hearts immediately after excision (prestorage) or immediately before transplantation (post-storage). All electron micrographs were independently examined by two morphologists. Eleven structures were examined in each micrograph, and each structure was scored according to the degree of injury. A good interobserver correlation was obtained in 84 % of the structures scored. In the prestorage left ventricular biopsies (n = 11), approximately 20 %–25 % showed moderate to severe ultrastructural injury. The ultrastructural injury observed in the poststorage left ventricular biopsies (n = 15) was no different from that in the prestorage group, particularly injury to the sarcomere and mitochondria. A similar degree and pattern of injury was seen in the right ventricle (n = 4). There was no evidence that an ischemic storage period of less than 6 h increased the degree of injury seen. However, there was a higher incidence of moderate to severe injury in those hearts excised from donors initially dependent on high inotropic support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02044338
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  • 10
    Electronic Resource
    Electronic Resource
    Towards the recovery of extrinsic camera parameters from video records of sewer surveys (1998)
    Springer
    Machine vision and applications 11 (1998), S. 53-63 
    Details
    ISSN: 1432-1769
    Keywords: Key words:Camera calibration – Vanishing point – Brick sewers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. The aim of the work reported here is the recovery, from a single image taken inside a roughly cylindrical brick sewer pipe of diameter up to one meter, of the pose of the camera relative to the central axis of the pipe. It is shown that the vanishing point associated with the longitudinal mortar lines carries valuable information about the pose. A method for the automatic detection of this point is presented and used to analyse the camera rotations underlying a number of sewer survey videos. It is similarly shown how the angles between the images of the longitudinal lines can be used to recover information about camera pose. The techniques might form an active part of a more comprehensive image understanding system recovering the three-dimensional shape of a surveyed pipe from survey videos and/or be used as an experimental tool during the design of such a system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001380050090
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