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  • 1
    Electronic Resource
    Electronic Resource
    Detection and quantification of coronary artery calcification with electron-beam and conventional CT (1999)
    Springer
    European radiology 9 (1999), S. 620-624 
    Details
    ISSN: 1432-1084
    Keywords: Key words: CT ; Coronary disease ; Coronary arteriosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To identify patients with increased risk of having coronary artery disease (CAD), electron-beam computed tomography (EBCT) was used for years for quantifying calcifications of the coronary arteries. The first direct comparison between EBCT and conventional CT was performed to determine the reliability of widely available conventional CT for the assessment of the coronary calcium score. Fifty male patients with suspected CAD were investigated with both modalities, EBCT and conventional 500-ms non-spiral partial scan CT. Scoring of the coronary calcification was performed according to the Agatston method. Forty-two of these patients underwent coronary angiography for the assessment of significant luminal narrowing. The correlation coefficient of the score values of both modalities was highly significant (r = 0.982, p 〈 0.001). The variability between the two modalities was 42 %. Mean calcium score in patients with significant coronary luminal narrowing (n = 37) was 1104 ± 1089 with EBCT and 1229 ± 1327 with conventional CT. In patients without luminal narrowing (n = 5) mean calcium score was 73 ± 57 with EBCT and 26 ± 35 with conventional CT. Although images of the heart from conventional CT may suffer from cardiac motion artifacts, conventional CT has the potential to identify patients with CAD with accuracy similar to EBCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050720
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  • 2
    Electronic Resource
    Electronic Resource
    Designing a Monitoring Network for Contaminated Ground Water in Fractured Chalk (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 37 (1999), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: One of the challenges of monitoring network design in a fractured rock setting is the heterogeneity of the rocks. This paper summarizes the activities and problems associated with the monitoring of contaminated groundwater in porous, low-permeability fractured chalk in the Negev Desert, Israel. Preferential flow documented in the study area required siting the monitoring boreholes in the predominant fracture systems. Lineaments traced from aerial photographs were examined in the field to sort out the large-extension, through-going, multilayer fracture systems crossing the study area. At each proposed drilling site, these fractures were exposed below the sediment cover using trenches. Slanted boreholes were drilled at a distance from the fracture systems so that each borehole would intersect the targeted fracture plane below the water table. Based on their short recovery period and contaminated ground water, these newly drilled, fracture-oriented boreholes appeared to be better connected to preferential flowpaths crossing the industrial site than the old boreholes existing on site. Other considerations concerning the drilling and logging of monitoring boreholes in a fractured media were: (1) coring provides better documentation of the vertical fracture distribution, but dry augering is less costly and enables immediate ground water sampling and the sampling of vadose rock for contaminant analysis; (2) caliper and TV camera logs appear to provide only partial information regarding the vertical fracture distribution; and (3) the information gained by deepening the monitoring boreholes and testing fractures crossing their uncased walls has to be carefully weighed against the risk of potential cross-contamination through the monitoring boreholes, which is enhanced in fractured media.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1999.tb00956.x
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  • 3
    Electronic Resource
    Electronic Resource
    Discovery of a planet orbiting a binary star system from gravitational microlensing (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 402 (1999), S. 57-59 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The properties of the recently discovered extrasolar planets were not anticipated by theoretical work on the formation of planetary systems, most models for which were developed to explain our Solar System. Indeed, the observational technique used to detect these planets (measurement of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/46990
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  • 4
    Electronic Resource
    Electronic Resource
    House dust mite allergen levels in two cities in Canada: effects of season, humidity, city and home characteristics (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The homes of 120 patients with asthma, 57 in Vancouver and 63 in Winnipeg, were studied. The characteristics of the homes were assessed by a questionnaire. Dust samples were collected and the indoor relative humidity was measured four times during the year covering all four seasons in both cities. Mite allergen levels were determined using monoclonal antibodies against Der p I and Der f I by the ELISA method. The mean levels of both mite allergens in mattress and floor samples in the homes in Vancouver and in Winnipeg were relatively low for all seasons. Mite allergen levels were found to be associated with city, season and individual home differences. They were significantly higher in Vancouver than in Winnipeg. Der p I and Der f I in mattress samples in both cities and Der f I in floor samples in Vancouver, varied by season. The indoor relative humidity level in the homes in Vancouver were also significantly higher than those in Winnipeg. There was, however, no significant association between the levels of indoor relative humidity and the levels of mite allergens after adjusting for variations in city, season and individual home. Although individual home differences were highly associated with mite allergen levels, only a few home characteristics were found to be related to mite allergen levels such as the type and the age of the home, the type of heating, the use of feather pillows and the number of occupants in the homes. Whether low levels of mite allergens are partially responsible for the relatively low prevalence of childhood asthma in Canada remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb01035.x
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  • 5
    Electronic Resource
    Electronic Resource
    Surface Action and Fluid Film Lubrication (1926)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 18 (1926), S. 471-477 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50197a008
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  • 6
    Electronic Resource
    Electronic Resource
    FATIGUE, CREEP AND CREEP/FATIGUE BEHAVIOUR OF A NICKEL BASE SUPERALLOY AT 700°C (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 20 (1997), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— This paper presents the results of an experimental testing programme to examine the uniaxial creep, low cycle fatigue and creep/fatigue interaction behaviour of a Ni-base superalloy at 700°C. The material is used in the manufacture of aeroengine turbine discs. A creep continuum damage mechanics model is shown to be capable of accurately predicting the creep and creep rupture behaviour of the material. A healing term has been incorporated into the damage mechanics model to allow the behaviour under creep/fatigue conditions to be described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1997.tb01488.x
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  • 7
    Electronic Resource
    Electronic Resource
    Enhanced cold front propagation due to turbulent mixing (1997)
    Springer
    Meteorology and atmospheric physics 62 (1997), S. 201-214 
    Details
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary The influence of turbulent friction on the propagation of cold fronts is investigated by numerical simulations using a two-dimensional mesoscale model. We compare the frictional effect with the effects of large-scale shear forcing and energy conversion at the earth's surface and discuss the synergic effect of all three mentioned processes. There is no pure superposition of these effects indicating that nonlinear interaction plays a role. In addition it is possible to show that—depending on the along-front jet—friction does not necessarily slow down the front but can also accelerate it. The direction of the along-front jet within the planetary boundary layer (PBL) is crucial for that question.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01029702
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  • 8
    Electronic Resource
    Electronic Resource
    The regulatory protein MucR binds to a short DNA region located upstream of the muc R coding region in Rhizobium meliloti (1997)
    Springer
    Molecular genetics and genomics 254 (1997), S. 529-538 
    Details
    ISSN: 1617-4623
    Keywords: Key words Regulation of gene expression  ;  Rhizobium meliloti  ;  Exopolysaccharide biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Rhizobium meliloti MucR protein is known to regulate the biosynthesis of the two exopolysaccharides, succinoglycan and galactoglucan. The mucR gene was successfully overexpressed in Escherichia coli BL21 cells by heat shock induction using a two-plasmid system. Cell extracts of the production strain contained about 20% of a polypeptide of 17 kDa apparent molecular mass, corresponding to the size expected for MucR. As shown by an electrophoretic mobility shift assay, these extracts were active in the specific retardation of a 219-bp DNA fragment including 134-bp of the non-coding region upstream of the mucR gene. Primer extension analysis showed that this DNA fragment was located within the transcribed region upstream of the mucR gene. Competition experiments revealed that a 44-bp sequence present within the 134-bp upstream of the mucR gene contained the MucR binding site. Although binding of MucR to this site exhibited a moderate dissociation constant of $K_{\rm d} \approx 1.4 \times10^{-7}$ M, the reaction was highly specific since fragments containing binding sites for the homologous Ros protein from Agrobacterium tumefaciens were not able to compete for MucR binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050448
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  • 9
    Electronic Resource
    Electronic Resource
    The Sinorhizobium meliloti MucR protein, which is essential for the production of high-molecular-weight succinoglycan exopolysaccharide, binds to short DNA regions upstream of exoH and exoY (1998)
    Springer
    Molecular genetics and genomics 257 (1998), S. 433-441 
    Details
    ISSN: 1617-4623
    Keywords: Key words Regulation of gene expression ; Sinorhizobium meliloti ; Rhizobium meliloti ; Exopolysaccharide biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sinorhizobium meliloti (Rhizobium meliloti) is able to produce two different exopolysaccharides, succinoglycan and galactoglucan. Mutations in the mucR gene of S. meliloti result in the stimulation of galactoglucan synthesis, while the type of succinoglycan produced is modified. In culture supernatants of a mucR mutant, low-molecular-weight succinoglycan is present, whereas no high-molecular-weight succinoglycan could be detected. The biosynthesis of succinoglycan is directed by the products of the exo gene cluster. Two DNA fragments from this cluster, one located in front of the exoH gene and one in the intergenic region between the divergently transcribed genes exoX and exoY, were shown to represent effective binding sites for MucR. Whereas the latter binding site contains an inverted repeat motif, the former does not. However, the binding of MucR did not strongly modify the transcription of the exo genes involved. In the mucR mutant the expression levels of exoH-lacZ and exoX-lacZ transcriptional fusions were found to be increased 1.5- and 1.7-fold, respectively. On the other hand, the expression level of an exoY-lacZ transcriptional fusion was found to be 1.5-fold lower in the mucR mutant than in the wild-type background. Comparison of the DNA sequences of MucR-binding sites provides insight into the structural requirements for binding of MucR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050667
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  • 10
    Electronic Resource
    Electronic Resource
    The eff-482 locus of Sinorhizobium meliloti CXM1-105 that influences symbiotic effectiveness consists of three genes encoding an endoglycanase, a transcriptional regulator and an adenylate cyclase (1999)
    Springer
    Molecular genetics and genomics 261 (1999), S. 1032-1044 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsRhizobium-legume symbiosis ; Rhizobium meliloti ; Succinoglycan degradation ; Repressor ; cAMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The mutant T482 of Sinorhizobium meliloti CXM1-105, which carries a Tn5 insertion on megaplasmid 1, exhibits an enhanced symbiotic efficiency phenotype. Three genes, eglC, cya3 and syrB2, were identified in the eff-482 region tagged by the Tn5 insertion in T482. The eglC gene encodes an endoglycanase which contributes to the depolymerization of the exopolysaccharide succinoglycan. The N-terminal region of the predicted cya3 gene product was similar to eukaryotic-type adenylate cyclases from Brevibacterium liquefaciens and Streptomyces coelicolor. Four contiguous tetratricopeptide repeats which are known to mediate protein-protein interactions were identified in the C-terminal portion of Cya3. Complementation analysis demonstrated that cya3 indeed encodes a functional adenylate cyclase. A central helix-turn-helix DNA-binding motif and a putative C-terminal coiled-coil structure implicated in protein oligomerization were found in SyrB2. Extra copies of the syrB2 gene negatively affect transcription of both syrB2 itself and cya3. The Tn5 insertion in T482 was localized between the divergently transcribed genes eglC and syrB2. It eliminated eglC function and slightly stimulated transcription of both syrB2 and cya3, which lies downstream of syrB2. Mutants carrying insertions of the lacZ-Gm interposon in the genes eglC, syrB2 and cya3 exhibit the same phenotype as mutant T482, indicating that these three genes influence symbiotic efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051052
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