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  • 1
    Electronic Resource
    Electronic Resource
    Relationship of changes in cardiac output to changes in heart rate in medical ICU patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 409-414 
    Details
    ISSN: 1432-1238
    Keywords: Key words Blood pressure ; Cardiac output ; Catherization ; Swan-Ganz ; Critical care ; Heart ; Monitoring ; physiologic ; Heart rate ; Thermodilution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine whether changes in cardiac output are correlated with changes in other commonly measured covariables (heart rate, respiratory rate, mean arterial pressure, mean pulmonary artery pressure, pulmonary artery occlusion pressure, and temperature). Design: Case series. Setting: Medical intensive care unit (ICU) in a Veterans Administration Medical Center. Patients: Twenty-three patients with Swan-Ganz catheters placed by the primary care team were studied on 25 occasions. Patients were managed by the primary team as clinically indicated. Interventions: Thermodilution cardiac output and covariables were determined at baseline and at hourly intervals for the next 5 h. Each cardiac output measurement was calculated by averaging the last four of five individual measurements at each time point. Results: The mean cardiac output (9.2 l/min), heart rate (107/min), and pulmonary artery occlusion pressure (19 mmHg) were elevated. The hourly mean change in cardiac output was 10.2%. Using least-squares linear regression analysis, we found clinically significant changes in cardiac output (〉6.4%) to be most closely correlated with changes in heart rate (R 2=0.29, p〈0.001). Stepwise linear regression analysis showed that none of the other covariables added significantly to this relationship. No significant relationship was found between changes in cardiac output and changes in pulmonary artery occlusion pressure. Despite these correlations clinically significant changes in cardiac output were accompanied by changes in heart rate in the same direction only 62% of the time. Conclusion: Changes in cardiac output were best correlated with changes in heart rate. Changes in pulmonary artery occlusion pressure were not correlated with changes in cardiac output in this population of medical ICU patients. A change in any of the covariables (alone or in combination) cannot be reliably used to indicate a simultaneous change in cardiac output.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712156
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship of changes in cardiac output to changes in heart rate in medical ICU patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 409-414 
    Details
    ISSN: 1432-1238
    Keywords: Blood pressure ; Cardiac output ; Catherization ; Swan-Ganz ; Critical care ; Heart ; Monitoring physiologic ; Heart rate ; Thermodilution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To determine whether changes in cardiac output are correlated with changes in other commonly measured covariables (heart rate, respiratory rate, mean arterial pressure, mean pulmonary artery pressure, pulmonary artery occlusion pressure, and temperature). Design Case series. Setting Medical intensive care unit (ICU) in a Veterans Administration Medical Center. Patients Twenty-three patients with Swan-Ganz catheters placed by the primary care team were studied on 25 occasions. Patients were managed by the primary team as clinically indicated. Interventions Thermodilution cardiac output and covariables were determined at baseline and at hourly intervals for the next 5 h. Each cardiac output measurement was calculated by averaging the last four of five individual measurements at each time point. Results The mean cardiac output (9.2l/min), heart rate (107/min), and pulmonary artery occlusion pressure (19 mmHg) were elevated. The hourly mean change in cardiac output was 10.2%. Using least-squares linear regression analysis, we found clinically significant changes in cardiac output (〉6.4%) to be most closely correlated with changes in heart rate (R 2=0.29,p〈0.001). Stepwise linear regression analysis showed that none of the other covariables added significantly to this relationship. No significant relationship was found between changes in cardiac output and changes in pulmonary artery occlusion pressure. Despite these correlations clinically significant changes in cardiac output were accompanied by changes in heart rate in the same direction only 62% of the time. Conclusion Changes in cardiac output were best correlated with changes in heart rate. Changes in pulmonary artery occlusion pressure were not correlated with changes in cardiac output in this population of medical ICU patients. A change in any of the covariables (alone or in combination) cannot be reliably used to indicate a simultaneous change in cardiac output.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712156
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  • 3
    Electronic Resource
    Electronic Resource
    IgG rheumatoid factors isolated by the surface-displaying phage library technique (1997)
    Springer
    Immunogenetics 45 (1997), S. 301-310 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Our analysis of IgG rheumatoid factors (RFs) from three patients with rheumatoid arthritis (RA) revealed that most contained significant numbers of skewed mutations per V region, suggesting that these RFs arose from antigen-driven responses. To further study IgG RFs in RA, we used pComb3 vector to construct an IgG1,λ combinatorial antibody library from a synovial fluid sample. After panning against human IgG, Fab fragments from 71/96 phage clones bound to Fc-coated wells. Sequence analysis of 20 randomly chosen Fc-binders showed that 17 (85%) clones had identical heavy (H) and light (L) chain V regions, represented by Humha311 and Humla211, respectively. Of the remaining three clones, two had the same Humla211 L chain, but each with a different H chain V region. All the putative germline V genes for these RFs also encode RF in RA patients. However, none of these RF V regions are similar to those of the two IgG RFs derived by the hybridoma technique from the same synovial fluid. The Humha311 H chain has two frameshifts: a one-base insertion upstream of the JH region and a four-base deletion near the end of the CH1 region, resulting in a mainly unconventional amino acid sequence in the CH1 region. In the future, it will be important to study the presence of IgG molecules with such unconventional CH1 amino acid sequences, and the effects of these amino acid sequences on the structures and immunological properties of the IgG molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050209
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate (1997)
    Springer
    Experimental brain research 115 (1997), S. 15-24 
    Details
    ISSN: 1432-1106
    Keywords: Key words Dorsal horn ; Second messengers ; Protein kinase C ; Protein kinase A ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Intradermal injection of capsaicin results in sensitization of spinothalamic tract cells to brushing and pressure applied to the cutaneous receptive field in anesthetized monkeys. A significant increase in background activity also occurs immediately after capsaicin injection that lasts for at least 2 h. A 40–50% decrease in the response to noxious heat stimuli is also observed following capsaicin injection. This study investigated the spinal role of second messengers by extracellularly recording from spinothalamic tract cells and delivering inhibitors of second messenger pathways to the spinal cord by microdialysis. Blockade of protein kinases with the general protein kinase inhibitor, H7 (5.0 mM, n = 6), reduced the sensitization of the cells to brush and pressure. Blockade of protein kinase C with NPC15437 (10.0 mM, n = 10) reduced the increased background activity and the increased responses to brush. Blockade of protein kinase A with H89 (0.01 mM, n = 9) was most effective. H89 reduced the background activity, the increased responses to brush and press, and reversed the decreased response to noxious heat stimuli. Blockade of G-proteins with the general G-protein inhibitor, GDP-β-S (1.0 mM, n = 9), reduced the background activity and the responses to brush and pressure without affecting the decreased response to heat. Thus, multiple intracellular messengers appear to be involved in the processing of central sensitization induced by activation of C-fibers following intradermal injection of capsaicin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005675
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  • 5
    Electronic Resource
    Electronic Resource
    High Strain Rate Superplasticity in 10vol.% SiC Particulate Reinforced AZ31 Magnesium Alloys (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 304-306 (Feb. 1999), p. 285-290 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.304-306.285.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Pulse NMR Study of Glass Transition in Maltodextrin (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 64 (1999), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A pulse nuclear magnetic resonance (NMR) technique was used to study the glass transition in maltodextrins. The spin-lattice relaxation time (T1 and spin-spin relaxation time (T2) of different molecular weight maltodextrins at different moisture contents and temperatures were measured using the pulse NMR tech nique. T1, and T2 were plotted against temperatures. From the resultant curves, the state transitions were observed and the corresponding state transition temperatures were determined. The state transition temperatures were very close to the glass transition temperatures (Tgs) determined with differential scanning calorimetry, suggesting a strong relationship between glass transition and proton relaxation behavior. Results indicate pulse NMR-based instrumentation could be very effective for the study of glass transition in food polymers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1999.tb09850.x
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  • 7
    Electronic Resource
    Electronic Resource
    STUDIES OF HARDNESS AND WATER MOBILITY OF COOKED WILD RICE USING NUCLEAR MAGNETIC RESONANCE (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food processing and preservation 21 (1997), S. 0 
    Details
    ISSN: 1745-4549
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The changes in hardness and molecular mobility of water of cooked wild rice during 10 days storage were investigated in this study. Seven grades of wild rice were subjected to various degrees of soaking and cooking and were stored at 5C. Nuclear magnetic resonance (NMR) technique was employed to determine the free induction decay (FID) signals and spin-spin relaxation time constants (T2) of protons, which was regarded as a measure of rotational molecular mobility of water in the samples. Multi-component behavior of FID signals was observed, based on which water molecules in the samples were classified into three fractions with different T2s. The hardness of the samples was assessed using a texture analyzer. All samples firmed over the storage period, which correlated well with the changes in NMR parameters. A multiple variable regression model was proposed to describe the relationships between firming and NMR parameters in the wild rice samples. The model demonstrates the possibility of using NMR parameters to assess and predict the firmness of the samples during storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4549.1997.tb00770.x
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  • 8
    Electronic Resource
    Electronic Resource
    Rapid Food Particle Temperature Mapping During Ohmic Heating Using FLASH MRI (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 64 (1999), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A fast low angle shoot (FLASH) pulse sequence in combination with a multi-inversion procedure was used to rapidly acquire spin-lattice relaxation data for food particles undergoing ohmic heating. The relaxation data acquired by magnetic resonance imaging (MRI) were analyzed using a two-component exponential model to extract both short and long spin-lattice relaxation time, T1. The longer T1 showed a better linear relationship with temperature than the shorter T1 and, therefore, was used to produce more reliable temperature maps. The MRI temperature maps constructed for ohmically heated food particulates showed an entirely different heating pattern than would be found for similar but conventionally heated particulates and indicated that the temperature inside the particulate could be higher than near the surface of the particulate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1999.tb12273.x
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  • 9
    Electronic Resource
    Electronic Resource
    Optimizing the giant magnetoresistance of symmetric and bottom spin valves (invited) : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5277-5281 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have attempted to optimize the values of the giant magnetoresistance in symmetric spin valves of the type NiO/Co/Cu/Co/Cu/Co/NiO (achieving 23.4%) and in bottom spin valves of the type Co/Cu/Co/NiO (achieving 17.0%), the largest values ever reported for such structures. The key elements in this achievement are improved vacuum conditions and careful attention to the film thicknesses. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361352
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  • 10
    Electronic Resource
    Electronic Resource
    Ab Initio Molecular Orbital Study of Toleune and Its Derivatives (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 15023-15027 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100041a017
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