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  • 1
    Electronic Resource
    Electronic Resource
    A 32-channel preamplifier chip for the multiplicity vertex detector at PHENIX (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 1684-1687 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The TGV32, a 32-channel preamplifier–multiplicity discriminator chip for the multiplicity vertex detector (MVD) at PHENIX, is a unique silicon preamplifier in that it provides both an analog output for storage in an analog memory and a weighted summed-current output for conversion to a channel multiplicity count. The architecture and test results of the chip are presented. Details about the design of the preamplifier, discriminator, and programmable digital–analog converters performance as well as the process variations are presented. The chip is fabricated in a 1.2 μm, n-well, complementary metal–oxide–semiconductor process. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149651
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  • 2
    Electronic Resource
    Electronic Resource
    A photospectrometer realized in a standard integrated circuit process (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 377-383 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A photospectrometer has been realized in a standard integrated circuit (IC) process. Only the masks, materials, and fabrication steps inherent to this IC process were used (i.e., no post processing to add mechanical or optical devices for filtering). The spectrometer was composed of a set of 18 photodetectors with independent spectral responses. The responses of these devices were weighted and summed to form outputs proportional to the input optical power in discrete wavelength bands in the region from ∼400 to ∼1100 nm. With the solution space restricted to a 60 nm band, this instrument could resolve Gaussian input spectra (σ=5 nm) with a peak-to-peak spacing of less than 15 nm. This device could easily be integrated with additional analog, digital, or wireless circuits to realize a true laboratory instrument on-a-chip. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148457
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  • 3
    Electronic Resource
    Electronic Resource
    Pronounced resting bradycardia in male elite runners is associated with high heart rate variability (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 7 (1997), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Forty-eight hour Holter monitoring was undertaken of 16 male elite middle- and long-distance runners, age 25±3 years, with peak oxygen uptake 4.83±0.43 1 O2/min or 73.0±3.9 ml O2/kg/min. The athletes had pronounced bradycardia during the night-time, with heart rate calculated from four RR intervals 〈30 beats/min in five runners. Twelve of 16 runners had RR intervals 〉2 s. Of those, 10 runners had sinus pauses exceeding 2 s, the longest being 3.06 s. Three runners had AV block II, two with Mobitz type 1, and one with both Mobitz type 1 and 2. Autonomic function was estimated by time domain and power spectral analysis of heart rate variability. The runners were compared with a control group of 13 sedentary or moderately active subjects. The runners had a mean of 14 b.p.m. lower heart rate at night than the controls. The runners had higher heart rate variability in all spectral bands. In the time domain pNN50 and rMSSD, which are considered to reflect strongly vagal tone, were markedly higher in the runners than the controls. The findings suggest that an increased parasympathetic tone might at least partly explain the pronounced resting sinus bradycardias found in endurance-trained runners.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0838.1997.tb00152.x
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  • 4
    Electronic Resource
    Electronic Resource
    Amplitude and timing of electromyographic activity during sprinting (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 6 (1996), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The aim of this study was to make descriptive analyses of the muscle activities in the lower extremity during maximal sprinting. Nine healthy sprinters were examined during maximal sprinting using telemetric electromyography (EMG). Seven muscles of the lower extremities were investigated: biceps femoris, medial hamstrings (semimembranosus and semitendinosus), rectus femoris, gluteus maximus, tibialis anterior, lateral gastrocnemius and medial gastrocnemius. The recorded EMG levels during running were expressed as percentage of maximum voluntary isometric contractions (%max EMG). For each muscle, the normalized EMG was plotted during the whole running stride cycle and is presented for each muscle. The reason for using this method is to show that it is possible to compare different muscle activities in a runner as well as to make comparisons between runners. Lateral and medial hamstrings and gluteus maximus showed similar activities with peak levels of EMG during footstrike. Rectus femoris had a two-peak activity, with one peak at the middle of the stance phase and the other during the swing phase. The tibialis anterior also showed a two-peak activity, but with the peaks at the beginning of the swing phase and just before foot-strike. The highest activities of the medial and lateral gastrocnemius occurred just before toe-off.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0838.1996.tb00064.x
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  • 5
    Electronic Resource
    Electronic Resource
    The role of catecholamines in desmopressin induced locomotor stimulation (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 1103-1115 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Catecholamines ; dopamine ; desmopressin ; locomotor activity ; rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Central and peripheral administration of DDAVP increase locomotor activity in rats in doses that alter brain dopamine neurochemistry. In order to delineate the role of catecholamines in this behavioural effect of DDAVP, the effects of different catecholamine manipulating agents on DDAVP-induced locomotor stimulation were studied in rats. The catecholamine depleting agent reserpine (5 mg/kg), administered alone or together with the catecholamine synthesis inhibitor α-methyltyrosine (250 mg/kg), completely prevented the locomotor stimulatory effect of DDAVP. The dopamine D1 receptor antagonist Sch-23390 (0.01 and 0.03 mg/kg) significantly antagonized the DDAVP-induced locomotor stimulation when adminis-tered in the higher dose, that also produced a significant reduction of locomotor activity per se, whereas the dopamine D2 receptor antagonist raclopride (0.08 and 0.16 mg/kg) had no significant effect. The two dopamine blockers administered together produced a significant, dose-dependent reduction of DDAVP-induced locomotor stimulation, while controls were not significantly affected. Also the α-adrenoceptor antagonist phenoxybenzamine decreased the DDAVP-induced locomotor stimulation in a dose (20 mg/kg) that did not influence locomotor activity in controls, and, finally, administration of Sch-23390, raclopride and phenoxybenzamine antagonised the DDAVP-induced effect in a dose combination that failed to influence locomotor activity per se. In vivo microdialysis experiments in awake, freely moving rats indicated that DDAVP increases dopamine overflow in the nucleus accumbens, a brain area of importance for initiation of locomotor activity, by approximately 25%, as compared to baseline levels. Taken together, these results indicate that the central stimulatory action of DDAVP involves granula-mediated dopamine release and subsequent activation of dopamine D1 and D2 receptors, and that α-adrenoceptors possibly also are involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050115
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  • 6
    Electronic Resource
    Electronic Resource
    Involvement of the medial geniculate body in prepulse inhibition of acoustic startle (1999)
    Springer
    Psychopharmacology 141 (1999), S. 189-196 
    Details
    ISSN: 1432-2072
    Keywords: Key words Acoustic startle response ; Prepulse inhibition ; Sensorimotor gating ; Schizophrenia ; Medial geniculate body ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prepulse inhibition of acoustic startle is the normal reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Previous studies have shown that several neuroanatomical structures and pathways in the brain are involved in the modulation of prepulse inhibition. In the present study, the functional importance of the medial geniculate body (MG) in the modulation of prepulse inhibition was investigated. To this end, in vivo brain microdialysis probes were used to infuse drugs locally into the MG of awake, freely moving rats simultaneously with startle response and prepulse inhibition measurements in the same animals. Intrageniculate infusion of the sodium channel blocker, tetrodotoxin, significantly reduced prepulse inhibition without affecting baseline startle amplitude. A similar effect was obtained after intrageniculate infusion of the GABAB receptor agonist, baclofen. In addition, intrageniculate infusion of muscimol, an agonist at the GABAA receptor complex, reduced prepulse inhibition, although this effect was obtained at a higher concentration of the drug compared to that of baclofen. These studies suggest that the MG is involved in the modulation of prepulse inhibition and that auditory signals relayed via the MG may be subjected to inhibitory control at this level, involving GABA neurotransmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050824
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  • 7
    Electronic Resource
    Electronic Resource
    A method of measuring energy dissipation during crack propagation in polymers with an instrumented ultramicrotome (1996)
    Springer
    Journal of materials science 31 (1996), S. 655-662 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In order to characterize very local energy dissipation during crack propagation in polymers, an ultramicrotome was instrumented to measure the energy dissipated during sectioning. The work to section per unit area, W s, was measured for five different amorphous polymers [polymethyl methacrylate (PMMA), polystyerene (PS), polycarbonate (PC) and two epoxy resins] in the glassy state. When the section thickness was varied between 60 and 250 nm, W s varied between 15 and 100 Jm−2, depending on the material and section thickness. The method and the results are compared with other methods used for determining the energy dissipation at a local level as well as at a macroscopic level in polymers. The differences between different polymers were found to be contradictory to macroscopic fracture toughness, G lc, measurements. The material that showed the highest W s had the lowest G lc values reported. Possible mechanisms for energy dissipation during sectioning are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00367882
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  • 8
    Electronic Resource
    Electronic Resource
    Immunolabeled microtubules and microfilaments are visible in multiple cell layers of rye root tip sections (1996)
    Springer
    Protoplasma 191 (1996), S. 215-219 
    Details
    ISSN: 1615-6102
    Keywords: Laser scanning confocal microscopy ; Multiple cell layers ; Plant microtubules ; Plant microfilaments ; Roots ; Tissue clearing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A protocol was developed to observe plant microtubules and actin microfilaments in large tissue samples without physical sectioning. Rye (Secale cereale L. cv. Rymin) root tip pieces from two-day-old seedlings were fixed and processed for immunolabeling. Incubation times of 24–48 h were required to insure adequate penetration of fixatives, antibodies, and washing buffers. Clearing of the tissue with methyl salicylate reduced background auto-fluorescence that would otherwise interfere with the resolution of cytoskeletal structures. Microtubules or microfilaments in 5–7 cell layers were visualized using the optical-sectioning capability of laser scanning confocal microscopy (LSCM) and projected as three-dimensional images. The three-dimensional character of the cytoskeletal elements is retained when viewing stained cells of intact tissue. The net-like character of a microfilament array radiating out from a single point into the cytoplasm is maintained when the cells are stained in intact root tip pieces and imaging is accomplished in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01281819
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