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  • 1
    Electronic Resource
    Electronic Resource
    Cyclooxygenase-2 as a therapeutic target (1998)
    Springer
    Inflammation research 47 (1998), S. 88-92 
    Details
    ISSN: 1420-908X
    Keywords: Key words: COX-2 inhibition — Cardiovascular disease — Anti-inflammatory — Therapeutic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Cyclooxygenase (COX)-2 is the predominant COX isoform present at sites of inflammation, and produces prostaglandins (PG) that cause swelling and pain. However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses. This is particularly likely in large blood vessels, where, under physiological conditions, the release of prostacyclin by COX-1, present in the endothelium, is an important component of cardiovascular homeostasis. We, and others, have recently shown that COX-2 can be induced by proinflammatory cytokines in human blood vessels, and also in human airway cells. Moreover, recent data from our group have suggested that in these structures, COX-2 is anti-inflammatory at the level of cellular proliferation, adhesion receptor expression, and cytokine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050287
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhaled nitric oxide in ARDS: modulator of lung injury? (1999)
    Springer
    Intensive care medicine 25 (1999), S. 1024-1026 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051002
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastrointestinal permeability following cardiopulmonary bypass: a randomised study comparing the effects of dopamine and dopexamine (1997)
    Springer
    Intensive care medicine 23 (1997), S. 510-516 
    Details
    ISSN: 1432-1238
    Keywords: Key words Cardiopulmonary bypass ; Gastrointestinal permeability ; Dopexamine ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To compare the effects of dopexamine and dopamine on the mucosal permeability of the gastrointestinal tract (GIT). Design: Prospective, randomised clinical trial. Setting: Intensive care unit of a postgraduate teaching hospital, London, England. Patients: Thirty patients undergoing elective surgery involving cardiopulmonary bypass, performed by a single surgeon. Interventions: Patients were randomly assigned to receive either dopexamine 2.0 μg/kg per min or dopamine 2.5 μg/kg per min for the duration of the study period. Measurements and main results: Hemodynamic parameters and gastric intramucosal pH (pHi) were measured at intervals throughout the study. GIT permeability was measured once, post-operatively, using the ratio of absorbed lactulose to L-rhamnose. The groups were similar with respect to demographics, pre- and post-operative risk factors. The lactulose/rhamnose ratio was (mean ± SEM) 0.44 ± 0.10 in the dopexamine group vs 0.65 ± 0.08 in that receiving dopamine (p 〈 0.05). The dopexamine group had a significantly higher oxygen delivery preoperatively (479.5 ± 32.0 ml/min per m2 vs 344.4 ± 23.9 ml/min per m2 for dopamine, p 〈 0.01), but no other significant differences emerged between the groups. Conclusions: Compared to dopamine, dopexamine reduces GIT permeability following surgery involving cardiopulmonary bypass. The mechanism of this effect remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050366
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  • 4
    Electronic Resource
    Electronic Resource
    Is bleomycin-detectable iron present in the plasma of patients with septic shock? (1997)
    Springer
    Intensive care medicine 23 (1997), S. 635-639 
    Details
    ISSN: 1432-1238
    Keywords: Key words Septicaemia ; Bleomycin-detectable iron ; Non-haem iron ; Iron overload
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess plasma iron status in critically ill patients with septic shock. Design: Observational, prospective study. Setting: Adult intensive care units in teaching and tertiary referral hospitals. Patients and participants: Fifteen adult patients with established septic shock. Normal control subjects (n = 10) were also investigated. Data from patients and controls were compared with previously published iron values in critical care patients. Measurements and results: The indices investigated and correlated with clinical scores of illness severity included bleomycin-detectable iron, non-haem iron; transferrin and its percentage iron saturation, and the iron binding (anti-oxidant) activity of transferrin. Bleomycin-detectable iron was not present in the plasma of patients with septic shock whilst the plasma transferrin remained unsaturated with iron. One patient in multi-organ failure displayed bleomycin-detectable iron in plasma (1.16 μmol/l) and had 100 % iron-saturation of transferrin. The plasma non-haem iron levels (7.84 ± 1.82 μmol/l) were the lowest of all critical care patient groups studied by us. The plasma transferrin levels were also low but resulted in a near normal percentage saturation of transferrin with iron (34.6 ± 6.5 %). The scores of clinical severity correlated with changes in plasma iron chemistry. Conclusions: Patients with septic shock rarely have iron saturated transferrin in their plasma leading to the presence of bleomycin-detectable iron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050386
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    ARDS: are we winning at last? (1998)
    Oxford : Blackwell Science Ltd
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1998.00631.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    NObel laurels, but where is the therapeutic advance?[Supported ] (1999)
    Oxford : Blackwell Science Ltd
    Anaesthesia 54 (1999), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1999.00956.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Round table conference: acute lung injury (1998)
    Springer
    Intensive care medicine 24 (1998), S. 878-883 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050680
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    Paper (German National Licenses)
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