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  • 1
    Electronic Resource
    Electronic Resource
    Clinical and basic studies on the G-1 column, a new extracorporeal therapeutic device effective in controlling rheumatoid arthritis (1998)
    Springer
    Inflammation research 47 (1998), S. 166-176 
    Details
    ISSN: 1420-908X
    Keywords: Key words: G-1 column — Extracorporeal perfusion — Rheumatoid arthritis — Granulocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The G-1 column, which is filled with cellulose acetate spherical beads of 2 mm diameter, is a new type of extracorporeal perfusion device originally designed to remove granulocytes from the venous circulation of patients with rheumatoid arthritis. A dramatic improvement in clinical symptoms was seen after treatment with the G-1 column in two successive clinical trials. Early effects include pain relief, reduction in the swollen joints, and a continued decrease in inflammation as a late effect. The results were further confirmed in the adjuvant arthritic rat model. G-1 beads adsorb some amounts of platelets at the beginning and then about a quarter of circulating neutrophils, monocytes, natural killer cells, and B cells, but not T cells. Various factors released from blood cells during transit through the column must have influenced the cells including lymphocytes which passed through the column. G-1 column actually eliminates some parts of aggressive leukocytes, but a more interesting story is the modification of blood components, which occurred in the G-1 column, and when returned to the patients, may have ameliorated the unbalanced homeostatic network and induced acceleration of healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050311
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  • 2
    Electronic Resource
    Electronic Resource
    Suppressive Effect of Prostaglandin E1 on Pulmonary Hypertension Induced by Monocrotaline in Rats (1999)
    Springer
    Lung 177 (1999), S. 77-88 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Monocrotaline—Pulmonary hypertension—Prostaglandin E1—Cytokine—Ca2+ influx.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effect of administering prostaglandin E1 (PGE1) on the extent of monocrotaline (MCT)-induced pulmonary hypertension and cytokine production [interleukins (IL) 1 and 6 and tumor necrosis factor (TNF)] by macrophages during MCT induction of pulmonary hypertension was studied. Right ventricle/left ventricle plus septum weight ratios (RV/LV + S) were used as an index of the development of pulmonary hypertension. Administering PGE1 at a dose of 0.2 mg/kg/day for 4 weeks reduced significantly the RV/LV + S ratio from 0.428 ± 0.070 to 0.243 ± 0.059 (p 〈 0.01) and decreased the production of these cytokines: IL-1, from 4.675 ± 3.558 to 1.800 ± 0.722 units; IL-6, from 0.322 ± 0.121 to 0.060 ± 0.039 units; and TNF, from 0.578 ± 0.369 to 0.004 ± 0.004 units. In another series of experiments, a significant reduction of the RV/LV + S ratio was noted for only 1 week when we administered PGE1 immediately after the injection of MCT. We confirmed that histopathologic improvements of lungs were noted by administering 0.2 mg/kg PGE1 for 4 weeks. In another experiment, PGE1 at a concentration of 2 μg/ml suppressed a rise in the cytosolic Ca2+ concentration of lipopolysaccharide-stimulated peritoneal macrophages of rats in vitro, suggesting that PGE1 suppressed cytokine production by macrophages through the suppression of the Ca2+ influx. These results suggest that administering PGE1 may be effective in the treatment of some forms of pulmonary hypertension in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007632
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  • 3
    Electronic Resource
    Electronic Resource
    A case of Werner's syndrome associated with systemic lupus erythematosus (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 199-203 
    Details
    ISSN: 1434-9949
    Keywords: Werner's Syndrome ; Systemic Lupus Erythematosus ; HLA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 40-year-old woman with Werner's syndrome associated with systemic lupus erythematosus (SLE) is reported. The patient exhibited short stature, slender extremities, thinned hair, high-pitched voice, cataracts, ulceration of the fingers, and mental retardation. Malar erythema, photosensitivity, and proteinuria had been noted since age 34. The serum contained high titers of antibodies to dsDNA, Sm, nRNP, and SS-A/Ro. The simultaneous presence of Werner's syndrome and SLE could be a coincidental occurrence of the two diseases, although it might be due to an abnormality in replication or degeneration of DNA leading to the development of both diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02214944
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 673-677 
    Details
    ISSN: 1434-9949
    Keywords: Autoimmune Hepatitis ; Mycobacterial 65 KD Heat Shock Protein ; Superoxide Dismutase ; Human 60 KD Heat Shock Protein ; Molecular Mimicry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antibody to 65 KD mycobacterial heat shock protein (HSP65) and antibody to human superoxide dismutase (H-SOD) were measured by ELISA in patients with autoimmune hepatitis (AIH), and results were compared with those of patients with chronic active hepatitis C (CAH-C) or systemic lupus erythematosus (SLE) and normal subjects (NS). Patients with AIH had significantly higher OD values of anti-HSP65 antibody and anti-H-SOD antibody compared with those of patients with CAH-C or SLE and NS. OD values of anti-HSP65 antibody were correlated with those of anti-SOD antibody. Affinity-purified anti-SOD antibody reacted with HSP65. Analysis of the amino acid sequence of human SOD showed that 7 segments, corresponding to r to 25 amino acid residues, exhibited 50 to 71% homology with that of mycobacterial HSP65.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207935
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistological Study of Endothelin-1 and Endothelin-A and B Receptors in Two Patients with Scleroderma Renal Crisis (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 425-427 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Scleroderma renal crisis and endothelin-1 – Systemic sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Scleroderma renal crisis (SRC) developed in two patients with systemic sclerosis (SSc) and they died from respiratory failure. Findings on autopsy revealed congestion and oedema in both lungs and intimal thickening of the small renal arteries in both patients. Immunohistological investigations showed positive staining of anti-human endothelin (ET)-1 in the media of the small renal arteries and ET-B receptor in the medial smooth muscle of the small renal arteries. This observation suggests an important pathophysiological role of ET-1 in the development of SRC in some patients with SSc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050132
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  • 6
    Electronic Resource
    Electronic Resource
    Clinico-Laboratory Characteristics of Patients with Dermatomyositis Accompanied by Rapidly Progressive Interstitial Lung Disease (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 462-467 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Autoantibodies – CD4+/CD8+ ratio – CK/LDH ratio – Dermatomyositis – Muscle weakness – Rapidly progressive interstitial lung disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n= 7) and those with chronic interstitial lung disease (C-ILD, n= 9), and also between deceased (seven RP-ILD and three C-ILD) and living patients (six C-ILD). The extent of muscle weakness of the extremities and frequency of autoantibody positivity were significantly lower in DM patients with RP-ILD than in DM patients with C-ILD. Furthermore, significantly lower serum ceatine kinase/lactate dehydrogenase levels (0.26 ± 0.27) were found in the 10 patients who died than in the six living patients (1.21 ± 1.09). A higher CD4+/CD8+ T-lymphocyte ratio in the peripheral blood (3.51 ± 2.65) was detected in the four DM patients with RP-ILD who died than in the six living DM patients with C-ILD (1.22 ± 0.49).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050139
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  • 7
    Electronic Resource
    Electronic Resource
    Complement-activating properties of IgM rheumatoid factors reacting with IgG subclasses (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 425-428 
    Details
    ISSN: 1434-9949
    Keywords: IgM Rheumatoid Factor ; Complement Activation ; IgG Subclass ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To estimate the complement-activating property (CAP) of IgM rheumatoid factor (RF), which was purified from synovial fluids of patients with rheumatoid arthritis, in a reaction with each IgG subclass, the activation and binding of C4 in the classical pathway of complement by IgM RF was measured in an enzyme-linked immunosorbent assay using biotinylated F(ab')2 antibody to human C4. The CAP of IgM RF reacting with IgG3 was significantly higher than that of IgM RFs bound to the other IgG subclasses (P〈0.01). These results suggest that IgM RF reacting with IgG3 in synovial fluid could induce a greater degree of complement-dependent inflammation in RA synovium than IgM RF reacting with other IgG subclasses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207676
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