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Effects of metronidazole on Porphyromonas gingivalis biofilms (1997)

Wright, T. L. ; Ellen, R. P. ; Lacroix, J.-M. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of periodontal research 32 (1997), S. 0

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ISSN: 1600-0765

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Subgingival bacteria exist within a biofilm consisting of cells and extracellular matrix which may afford organisms protection from both antibiotics and components of the host immune system. MIC values for planktonic Porphyromonas gingivalis treated with metronidazole were compared with those obtained for the same strain in biofilms associated with hydroxyapatite (HA) surfaces. The treated biofilms were examined for growth and studied by scanning electron microscopy. A broth assay resulted in an MIC of 0.125 μg/ml for metronidazole against P. gingivalis. P. gingivalis biofilms exhibited growth after treatment with 20μg/ml metronidazole, which was 160 times the MIC for planktonic organisms. The results of this study indicate that biofilm-associated P. gingivalis may be resistant to metronidazole at concentrations which are usually attained by systemic administration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0765.1997.tb00560.x

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Holographic variable attenuators for high-power Nd:YAG lasers (1995)

Asselin, D. ; Galarneau, P. ; Lacroix, J. M. ; [et al.]

Springer

Optical and quantum electronics 27 (1995), S. 1427-1432

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ISSN: 1572-817X

Source: Springer Online Journal Archives 1860-2000

Topics: Electrical Engineering, Measurement and Control Technology , Physics

Notes: Abstract Within the framework of the Eureka project EU-226: High Power Solid-State Lasers, we have investigated the possibility of making variable attenuators for industrial Nd:YAG lasers using holographic optical elements. Holographic variable attenuator (HVA) demonstrators were realized in fused silica for compatibility with multi-kilowatt Nd:YAG lasers. They were 40 mm long and 13 mm wide with transmission varying from 67% to 98%. Using two cascaded HVA, it was possible to vary the transmission from 44% to 97% using a probe beam of 850 μm. Moreover, no noticeable apodization was found on a 5-mm-diameter laser beam.