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  • 1
    Electronic Resource
    Electronic Resource
    High-dose chemotherapy and autologous hematopoieticstem cell transplantation in patients with second primary malignancies (1997)
    Springer
    Hematology and cell therapy 39 (1997), S. 79-83 
    Details
    ISSN: 1279-8509
    Keywords: Autologous bone marrow transplantation ; Autologous peripheral blood stem cell transplantation ; High-dose chemotherapy ; Second primary neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated 500 patients with high-dose chemotherapy and autologous bone marrow or autologous peripheral blood stem cell transplantation. Treated conditions included leukemia, lymphoma, breast cancer, lung cancer, germ-cell carcinoma, and other solid tumors. 10/500 (2%) of patients were treated for a second malignancy diagnosed 12 months to 25 years after their initial neoplasm. Four of these ten patients are in complete remission (CR) of both malignancies at a median follow-up of 29+ months after high-dose chemotherapy and autotransplantation. None of these patients would have been eligible for high-dose chemotherapy and autotransplantation by conventional selection criteria which usually exclude patients with a history of prior malignancies. Conclusion. Conventional exclusion criteria for high-dose chemotherapy and autotransplantation may not adequately reflect the prognosis of patients with second or secondary malignancies treated with this therapeutic modality. High-dose chemotherapy and autologous hematopoietic stem cell transplantation may be of true benfit in selected cases of secondary malignancies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00282-997-0079-3
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  • 2
    Electronic Resource
    Electronic Resource
    Nimodipine Improves Information Processing in Substance Abusers (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 765 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb16571.x
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  • 3
    Electronic Resource
    Electronic Resource
    A rapid, apple-based test for virulence in Cryphonectria cubensis isolates (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Forest pathology 28 (1998), S. 0 
    Details
    ISSN: 1439-0329
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The presence of the Eucalyptus canker pathogen Cryphonectria cubensis in South Africa is of concern to the local forestry industry. Quantification of the virulence of this fungus through the inoculation of trees, is both time consuming, and expensive. In this study, the potential to use apples in screening for virulence of isolates of C. cubensis, was tested using different apple cultivars and inoculation procedures. The best indication of virulence was given on Golden Delicious apples incubated at 25°C for 14 days. Here, the lesion size associated with inoculations of C. cubensis, was found to correlate significantly with the virulence of the isolates, as determined by inoculations on trees.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0329.1998.tb01195.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Effects of Nimodipine on the EEG of Substance Abusers (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 765 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb16570.x
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  • 5
    Electronic Resource
    Electronic Resource
    Laser action below threshold inversion due to coherent population trapping (1996)
    Springer
    Applied physics 62 (1996), S. 221-225 
    Details
    ISSN: 1432-0649
    Keywords: 42.50.Hz ; 42.55.-f
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The possibility of ‘lasing without inversion’ on the 1079.8 nm line of a HeNe laser is investigated. It is shown that a modified double-Λ scheme can be realized by use of the 877.9 nm line for introducing Zeeman coherence. It is shown experimentally that Zeeman coherence can enforce laser action, even if the inversion is below threshold. A different choice of the polarization of the driving beam can result in suppression of laser action above threshold. The underlying mechanisms are examined. On the 611.8 nm line, laser action below threshold inversion is obtained with the driving beam tuned to 824.9 nm (‘up-conversion’).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01080948
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  • 6
    Electronic Resource
    Electronic Resource
    Identification and mapping of random amplified polymorphic DNA (RAPD) markers linked to resistance against beet necrotic yellow vein virus (BNYVV) in Beta accessions (1997)
    Springer
    Theoretical and applied genetics 94 (1997), S. 123-130 
    Details
    ISSN: 1432-2242
    Keywords: Key words Beet necrotic yellow vein virus  ; Beta vulgaris  ;  Bulked segregant analysis  ;  RAPD markers  ;  Resistance genes  ;  STS markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Molecular markers linked to resistance genes are useful to facilitate the introgression of one or more of these genes in breeding materials. Following the approach of bulked segregant analysis, RAPD markers linked to resistance genes against beet necrotic yellow vein virus were identified in the four Beta accessions Holly-1-4, R104, R128 and WB42. Two primers were found which generate RAPD markers tightly linked to resistance in segregating families of Holly-1-4, R104 and R128, indicating that the resistance genes in these accessions might be situated at the same locus. Other, specific, primers were identified which generate RAPD markers linked to resistance in each of these accessions. Short-range maps were established around the resistance locus in these accessions. For WB42, RAPD markers were only identified at a relatively large distance from the resistance gene. Conversion of three RAPD primers of Holly-1-4, R104 and R128 into STS primers resulted in STS markers which can be readily used for marker-assisted selection in breeding programmes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050390
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  • 7
    Electronic Resource
    Electronic Resource
    Inheritance of resistance to beet necrotic yellow vein virus in Beta vulgaris conferred by a second gene for resistance (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 740-746 
    Details
    ISSN: 1432-2242
    Keywords: Key words Beet necrotic yellow vein virus ; Beta vulgaris ; Inheritance ; Resistance genes ; Rhizomania ; STS markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract   Rhizomania is a serious disease of sugar beet, caused by beet necrotic yellow vein virus (BNYVV). The disease can only be controlled by the use of resistant cultivars. The accession Holly contains a single dominant gene for resistance, called Rz. The identification of a locus for resistance that differs from Rz would provide possibilities to produce cultivars with multiple resistance to BNYVV. Inheritance of resistance to BNYVV was studied by screening progenies of crosses between resistant plants of the accessions Beta vulgaris subsp. maritima WB42 and B. vulgaris subsp. vulgaris Holly-1–4 or R104. Observed and expected segregation ratios were compared to elucidate whether the resistance genes in the three accessions are alleles or situated on different loci. STS markers, linked to the genes for resistance, were used to study the segregation in more detail. The results demonstrated that the genes for resistance to BNYVV inHolly-1-4 and WB42 are closely linked. The gene for resistance in R104 is at the same locus as in Holly-1-4, and also closely linked to the gene in WB42. As the Holly resistance gene has been named Rz, the name Rz2 is proposed to refer to the resistance gene in WB42. Consequently, the gene Rz should be referred to as Rz1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051292
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation and characterization of RAPD-based markers linked to the beet cyst nematode resistance locus (Hs1 pat-1) on chromosome 1 of B. patellaris (1995)
    Springer
    Theoretical and applied genetics 90 (1995), S. 885-891 
    Details
    ISSN: 1432-2242
    Keywords: Randomly amplified polymorphic DNA (RAPD) ; Deletion mapping ; Sequence Tagged Site (STS) ; Monosomic fragment additions ; Beet cyst nematode resistance ; Heterodera schachtii Schm ; Beta patellaris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A beet cyst nematode (BCN)-resistant telosomic addition of B. patellaris chromosome 1 in B. vulgaris was used to isolate 6 RAPD markers linked to the BCN resistance locus Hs1 pat-1. Southern analysis showed that the analyzed RAPD products contain either low-, middle or high-repetitive DNA. The relative positions of the random amplified polymorphic DNA (RAPD) markers and of the restriction fragment length polymorphism (RFLP) loci corresponding to the low-repetitive RAPD products were determined by deletion mapping using a panel of seven nematode-resistant B. patellaris chromosome-1 fragment additions. One RAPD marker, OPB11800, was found to be present in two copies on the long arm telosome of B. patellaris chromosome 1. These copies are closely linked to the BCN resistance gene and flank the gene on both sides. On the basis of the nucleotide sequence of OPB11800, sequence-tagged site (STS) primers were developed that amplify specific fragments derived from the two OPB11800 loci. These STS markers can be used in the map-based cloning of the BCN gene, as they define start and finishing points of a chromosomal walk towards the Hs1 pat-1 locus. Two copies of the middle-repetitive OPX21100 marker were mapped in the same interval of the deletion mapping panel as the resistance gene locus and thereby belong to the nearest markers as yet found for the BCN gene in B. patellaris.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222027
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  • 9
    Electronic Resource
    Electronic Resource
    Selection of monosomic addition plants in offspring families using repetitive DNA probes in Beta L. (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 891-897 
    Details
    ISSN: 1432-2242
    Keywords: Beta vulgaris ; Beta patellaris ; Beta procumbens ; Monosomic additions ; PCR ; Repetitive probe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of two repetitive DNA probes Sat-121 and PB6-4, specific for the section Procumbentes of the genus Beta, was tested in 16 B. patellaris monosomic addition families using a dot-blot hybridization procedure. All monosomic additions were accurately distinguished from diploid sib plants with both DNA probes. The probe PB6-4, with the strongest signal after hybridization, was selected for rapid screening of an extensive number of putative monosomic additions in B. patellaris or B. procumbens addition families using a squash-blot hybridization procedure. The probe PB6-4 detected 118 monosomic additions in 640 plants (18.4%) in eight different B. procumbens addition families. The addition family with chromosome 4 of B. procumbens was semi-lethal and could not be tested. The distribution of PB6-4 in B. patellaris addition families was confirmed in 63 addition families using the squash-blot procedure. In 4580 plants of these addition families, 628 individual monosomic additions (13.7%) were found. The relationship of the morphological characteristics of monosomic addition plants to the results of the squash-blot hybridization (plants with signal) using probe PB6-4 is quite rigorous but not complete. The correlation between plants with a signal and chromosome number (2n=19) is complete. These results indicate that sequences present on PB6-4 are probably present on all chromosomes of B. patellaris and B. procumbens. The possibility of utilizing the sequence information of Sat-121 for a PCR-based assay to screen for putative monosomic addition plants was also investigated as an alternative to chromosome counting. The DNA-amplification profiles using the primers REP and REP.INV clearly distinguished monosomic addition plants from their diploid sibs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221903
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  • 10
    Electronic Resource
    Electronic Resource
    Selection of monosomic addition plants in offspring families using repetitive DNA probes in Beta L. (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 891-897 
    Details
    ISSN: 1432-2242
    Keywords: Key words  Beta vulgaris  ;  Beta patellaris  ;  Beta procumbens  ;  Monosomic additions  ;  PCR  ;  Repetitive probe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract   The distribution of two repetitive DNA probes Sat-121 and PB6-4, specific for the section Procumbentes of the genus Beta, was tested in 16 B. patellaris monosomic addition families using a dot-blot hybridization procedure. All monosomic additions were accurately distinguished from diploid sib plants with both DNA probes. The probe PB6-4, with the strongest signal after hybridization, was selected for rapid screening of an extensive number of putative monosomic additions in B. patellaris or B. procumbens addition families using a squash-blot hybridization procedure. The probe PB6-4 detected 118 monosomic additions in 640 plants (18.4%) in eight different B. procumbens addition families. The addition family with chromosome 4 of B. procumbens was semi-lethal and could not be tested. The distribution of PB6-4 in B. patellaris addition families was confirmed in 63 addition families using the squash-blot procedure. In 4580 plants of these addition families, 628 individual monosomic additions (13.7%) were found. The relationship of the morphological characteristics of monosomic addition plants to the results of the squash-blot hybridization (plants with signal) using probe PB6-4 is quite rigorous but not complete. The correlation between plants with a signal and chromosome number (2n=19) is complete. These results indicate that sequences present on PB6-4 are probably present on all chromosomes of B. patellaris and B. procumbens. The possibility of utilizing the sequence information of Sat-121 for a PCR-based assay to screen for putative monosomic addition plants was also investigated as an alternative to chromosome counting. The DNA-amplification profiles using the primers REP and REP.INV clearly distinguished monosomic addition plants from their diploid sibs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050208
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    Paper (German National Licenses)
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