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  • 1
    Electronic Resource
    Electronic Resource
    Self-limited traveller's diarrhea due to a dual infection withEnterocytozoon bieneusi andCryptosporidium parvum in an immunocompetent HIV-negative child (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 919-920 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691502
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  • 2
    Electronic Resource
    Electronic Resource
    Septicemia due to susceptibleEnterococcus faecalis despite prophylaxis with trimethoprim-sulfamethoxazole (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 620-622 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447931
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  • 3
    Electronic Resource
    Electronic Resource
    Prävalenz von Hepatitis B, Hepatitis C und HIV-Infektionen bei Drogentodesfällen in Hamburg (1985 bis 1997) unter Berücksichtigung von epidemiologischen, forensischen und morphologischen Aspekten (1999)
    Springer
    Rechtsmedizin 9 (1999), S. 205-209 
    Details
    ISSN: 1434-5196
    Keywords: Key words Drug abuse-related fatalities ; Hepatitis ; HBV ; HCV ; HIV ; Schlüsselwörter Drogentodesfälle ; Hepatitis ; HBV ; HCV ; HIV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Ziel dieser Untersuchung: Darstellung der (1) Prävalenzen von Hepatitis B (HBV), Hepatitis C (HCV) und HIV Infektionen bei Drogentodesfällen in Hamburg von 1985 bis 1997, (2) Mehrfachinfektionen, (3) Leberhistolgie von 100 autopsierten Drogentodesfällen. Desweiteren werden epidemiologische und forensische Aspekte diskutiert. 1469 Drogentodesfälle wurden in diesem Zeitraum registriert: (1) Die Gesamtprevalenzen stellen sich wie folgt dar: HBV 35% (1997: 39%); HCV 51% (1997: 58%); HIV 7% (1997: 15%). (2) Mehrfachinfektionen sind häufig (28%): 19% aller Drogentodesfälle wiesen eine HBV + HCV Infektion auf. (3) Leberhistologie: eine Hepatitis wurde in 74% diagnostiziert und war häufig assoziiert mit einer HBV und/oder HCV Infektion (77% aller feingeweblichen Hepatitis-Diagnosen). 9% zeigten eine unauffällige Leberhistologie. Rechtsmedizinische Obduktionen und das Monitoring von HBV, HCV und HIV Infektionen bei Drogentodesfällen stellen ein wichtiges Instument dar, um Informationen über den Einzelfall und die Situation bei i.v. Drogenabhängigen zu erhalten.
    Notes: Abstract The prevalence of hepatitis B, hepatitis C and HIV infections among drug abuse-related fatalities in Hamburg (1985–1997) was investigated with respect to epidemiological, forensic and morphological aspects. The purpose of this study was (1) to determine the prevalence of hepatitis B (HBV), hepatitis C (HCV) and HIV infections among drug abuse-related fatalities (drug deaths) in Hamburg from 1985 to 1997, (2) to assess the rate of multiple infections and (3) to analyze the liver histomorphology in 100 autopsied drug deaths. Furthermore, we discuss the epidemiological and forensic aspects. In this period 1469 drug deaths were registered with a prevalence for HBV of 35% (1997: 39%), for HCV 51% (1997: 58%), and for HIV 7% (1997: 15%). Co-infections were common (28%) and 19% of all cases were infected with HBV and HCV. The liver histology showed that hepatitis was frequently diagnosed (74%) and was associated with HBV and/or HCV infections (77% of all hepatitis cases). Only 9% showed a normal liverhistology. Forensic autopsies and monitoring of HBV, HCV and HIV infections in drug deaths represent an important tool to gain information about the individual case and the situation among i.v. drug abusers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001940050111
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  • 4
    Electronic Resource
    Electronic Resource
    Die vertikale Übertragung des Hepatitis-C-Virus von infizierten Müttern auf ihre Kinder Das Risiko der HCV-Übertragung durch Muttermilch ist gering (1999)
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 562-568 
    Details
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Hepatitis-C-Virus ; Vertikale Übertragung ; Muttermilch ; Key words Hepatitis C virus ; Vertical transmission ; Breast milk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Children of mothers chronically infected with hepatitis-C-virus (HCV) during pregnancy and delivery were prospectively followed. 90 children born to 85 infected mothers were included in our study; nine of the mothers were known to be co-infected with HIV-1. These 90 children were first tested within 60 days after birth and followed for at least three months. Three of the 90 children became infected perinatally with HCV as shown by persistence of antibodies after 2 years of life and a positive result in the RT-PCR. One of these 3 children has evidence of ongoing hepatitis as shown by slightly elevated alanine aminotransferase values, but is otherwise clinically well, likewise the other 2 infected children. 54 of the 87 uninfected children were followed until they lost maternal antibodies after an average of one year. In another part of the study we tested 76 breast milk samples from 73 chronically HCV-infected mothers for the presence of HCV-RNA. None of the samples was positive. One of the 76 children of these mothers became HCV-infected; the course of infection in this case favours an HCV-transmission during pregnancy or delivery and not by breast feeding. These data show that maternal HCV-infection should not be a contraindication for breast feeding.
    Notes: Zusammenfassung In einer prospektiven Studie wurde die vertikale Übertragungsrate des Hepatitis-C-Virus (HCV) von Müttern, die während Schwangerschaft und Entbindung HCV-infiziert waren, auf ihre Kinder untersucht. In das Studienkollektiv wurden 90 Kinder von 85 bekannten, chronisch HCV-infizierten Müttern aufgenommen. Von neun Müttern war eine gleichzeitige Infektion mit dem HIV-1 bekannt. Die Serumproben der 90 Kinder wurden innerhalb von acht Wochen nach der Entbindung erstmals untersucht; Nachuntersuchungen erfolgten über mindestens drei Monate. Drei der 90 Kinder wurden HCV-infiziert (3,3%), nachgewiesen durch eine Antikörperpersistenz über mindestens zwei Jahre sowie den Nachweis von HCV-RNA in der PCR. Eines der Kinder hatte leicht erhöhte Transaminasen, war aber klinisch wie die beiden anderen Kinder auch unauffällig. 54 der Kinder wurden so lange nachuntersucht, bis die mütterlichen Antikörper nicht mehr nachweisbar waren; dies war im Schnitt nach einem Jahr der Fall. In einem zweiten Teil der Studie wurden 76 Milchproben von 73 chronisch HCV-infizierten Müttern auf HCV-RNA untersucht. Keine der Proben war in der PCR reaktiv. Von den 76 Kindern dieser Mütter war nur eines HCV-infiziert; der Verlauf spricht bei diesem Kind für eine HCV-Übertragung unter der Geburt und nicht durch das Stillen. Eine HCV-Infektion der Mutter ist also keine Kontraindikation gegen das Stillen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001030050156
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  • 5
    Electronic Resource
    Electronic Resource
    Catalase-negativeListeria monocytogenes causing lethal sepsis and meningitis in an adult hematologic patient (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 965-967 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01690521
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  • 6
    Electronic Resource
    Electronic Resource
    Hepatitis C virus infection in pregnancy and the risk of mother-to-child transmission (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 121-124 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The risk of vertical transmission of the hepatitis C virus (HCV) from infected mothers to their children during pregnancy and delivery was determined in 120 children born to HCV-positive mothers. Methods included enzyme immunoassay and immunoblot for detection of HCV antibodies and reverse transcription polymerase chain reaction (RT-PCR) for detection of viral RNA. Six (5%) children were perinatally infected with HCV as shown by RT-PCR. None of the infected children had clinical signs of hepatitis. None of the pregnancies was complicated by abortion, stillbirth, premature birth, or malformation of the child. Special concern was given to the possibility of HCV transmission via breast milk. In no breast milk sample obtained from 34 HCV-infected mothers was HCV RNA detected. These observations indicate that HCV infection is not necessarily a contraindication for breast-feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709470
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  • 7
    Electronic Resource
    Electronic Resource
    Hepatitis C: Increasing knowledge and unresolved questions (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 105-106 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01591481
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  • 8
    Electronic Resource
    Electronic Resource
    SystemicPenicillium marneffei infection in a German AIDS patient (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 256-259 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01591368
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  • 9
    Electronic Resource
    Electronic Resource
    Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme (1999)
    Springer
    Archives of virology 144 (1999), S. 687-701 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Generally, the maximum activities of the protein kinases A* (PKA) and C (PKC) show an optimum value for their substrate concentrations rather than a saturation curve; at high substrate concentrations, the kinase activity is completely abolished. The C- and N-truncated form of the non-structural protein 3 (NS3) of hepatitis C virus (HCV) (HCV-polyprotein-(1 189–1 525)) abolishes the inhibiting effect of the substrate, yielding saturable Michaelis-Menten kinetics of PKA and its catalytical domain (C subunit). In contrast, HCV-polyprotein-(1 189–1 525) activates PKC with increasing Vmax, while it abolishes the substrate inhibition of its catalytical domain (M-kinase) through a mechanism analogous to that of PKA and C subunit. PKC isoforms α, β and γ investigated are similarly activated by HCV-polyprotein-(1 189–1 525). Our data suggest that NS3 attenuates the substrate inhibition through a generalized mechanism operating mainly on the substrate level that directly results from a specific protein-protein interaction. In the case of the PKC, an additional kinase activating mechanism operates on the enzyme level. Both actions of NS3, the attenuation of the substrate inhibition and the activation of PKC, could not be explained by classical means that predict autophosphorylation to enhance the rate of substrate phosphorylation. The results are discussed in view of similar activities displayed by matchmakers and some molecular chaperones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050536
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