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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Manuscripta mathematica 95 (1998), S. 413 
    ISSN: 1432-1785
    Keywords: Mathematics Subject Classification (1991): 14F10, 14M10, 14M17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract: The Frobenius automorphism of the function field allows to define some discrete birational invariants of algebraic manifolds using p s -th powers of differentials. Examples of algebraic hypersurfaces are sufficient to show the independence of the familiar birational invariants.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Key words Factor V G1691A ; Prothrombin G20210A ; Lipoprotein (a) ; Central venous lines ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the role of inherited thrombophilia in the development of central venous line (CVL)-related thrombosis, the following parameters were determined in 77 pediatric-oncologic patients with CVL: activated protein C (APC)-ratio, factor V (FV) G1691A and prothrombin G20210A mutation, protein C, protein S, antithrombin, coagulation factor XII, lipoprotein (a) and homocysteine. An inherited prothrombotic risk factor was found in 17 patients (23%). Four out of 14 patients with a single defect (hyperlipoproteinemia, heterozygous FV G1691A and prothrombin G20210A mutation, protein C deficiency type I) and all three patients with combined defects (heterozygous FV G1691A mutation combined with heterozygous prothrombin G20210A variant, protein S deficiency or hyperlipoproteinemia) suffered from CVL-related thrombosis. In 11 out of 77 patients (14%) a CVL-related thrombosis was detected. In 2 children thrombosis occurred a few days after asparaginase therapy and in another three thrombosis was associated with CVL-related septicemia caused by Staphylococcus epidermidis. After removal of CVL, thrombosis was detected in 5 children, in 2 without clinical symptoms but in the presence of inherited prothrombotic risk factors. Conclusion The present study demonstrates the clinical importance of CVL in combination with inherited thrombophilia in the development of thrombosis in pediatric-oncologic patients. Before or shortly after insertion of CVL, patients should be tested for the presence of factor V G1691A mutation, prothrombin G20210A variant and increased lipoprotein (a) values.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We investigated the expression of regulatory (R) and catalytic (C) subunits of cyclic AMP-dependent protein kinase (cAK; ATP:protein phosphotransferase; EC 2.7.1.37) in the bovine pineal gland. In total RNA extracts of bovine pineal glands moderate levels of RIα/RIIβ and high levels of Cα and Cβ mRNA were found. We were able to detect a strong signal for RII and C subunit at the protein level, whereas RI was apparently absent. Probing sections of the intact bovine pineal gland with RI and RII antibodies stained only RII in pinealocytes. Pairs of cyclic AMP analogues complementing each other in activation of type II cAK, but not cAKI-directed analogue pairs, showed synergistic stimulation of melatonin synthesis. Moreover, melatonin synthesis stimulated by the physiological activator norepinephrine in pineal cell cultures was inhibited by cAK antagonists. Taken together these results show the presence of RII regulatory and both Cα and Cβ catalytic subunits and thus cAKII holoenzyme in the bovine pineal gland. The almost complete inhibition of norepinephrine-mediated melatonin synthesis by the cAK antagonists emphasizes the dominant role of cyclic AMP as the second messenger and cAK as the transducer in bovine pineal signal transduction.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Perturbative experiments on the Tokamak Fusion Test Reactor [Phys. Plasmas 4, 1736 (1997)] (TFTR) have investigated transport in reverse shear plasmas. On TFTR, reverse magnetic shear plasmas bifurcate into two states with different transport properties: reverse shear (RS) and enhanced reverse shear (ERS) with improved core confinement. Measurements of the 14 MeV t(d,n)α neutrons and charge-exchange recombination radiation spectra are used to infer the trace tritium and helium profiles, respectively. The profile evolution indicate the formation of core particle transport barriers in ERS plasmas. The transport barrier is manifested by an order-of-magnitude reduction in the particle diffusivity (DT,DHe) and a smaller reduction in the pinch within the reverse shear region. The low diffusivities are consistent with neoclassical predictions. Furthermore, DT and DHe(approximate)χeff, the effective thermal diffusivity. Although the measured coefficients imply no helium ash accumulation, the situation is uncertain in a reactor due to unknown χeff scaling.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The electron temperature (Te) profile in neutral beam-heated supershot plasmas (Te0∼6–7 keV ion temperature Ti0∼15–20 keV, beam power Pb∼16 MW) was remarkably invariant when radiative losses were increased significantly through gas puffing of krypton and xenon in the Tokamak Fusion Test Reactor [McGuire et al., Phys. Plasmas 2, 2176 (1995)]. Trace impurity concentrations (nz/ne∼10−3) generated almost flat and centrally peaked radiation profiles, respectively, and increased the radiative losses to 45%–90% of the input power (from the normal ∼25%). Energy confinement was not degraded at radiated power fractions up to 80%. A 20%–30% increase in Ti, in spite of an increase in ion–electron power loss, implies a factor of ∼3 drop in the local ion thermal diffusivity. These experiments form the basis for a nearly ideal test of transport theory, since the change in the beam heating power profile is modest, while the distribution of power flow between (1) radiation and (2) conduction plus convection changes radically and is locally measurable. The decrease in Te was significantly less than predicted by two transport models and may provide important tests of more complete transport models. At input power levels of 30 MW, the increased radiation eliminated the catastrophic carbon influx (carbon "bloom") and performance (energy confinement and neutron production) was improved significantly relative to that of matched shots without impurity gas puffing. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Tritium on the inside walls of the Tokamak Fusion Test Reactor was detected by configuring the vacuum vessel as an ionization chamber and measuring the secondary electron current from the tritium beta decay. The vessel was typically filled with (approximate)5 Torr of dry nitrogen and the secondary electron current was collected by an internal electrode biased to about +15 V with respect to the vessel wall. The measured variations of the collected current with gas pressure, bias voltage, and applied magnetic fields are described, as well as an in situ calibration made by injecting a known amount of tritium gas. Improved versions of this diagnostic may be useful to track the in-vessel content of surface tritium in future fusion devices. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Three potential methods for evaluating the surface tritium content of the TFTR vacuum vessel are described, each based on a different technique for measuring the in situ beta emission from tritium. These methods should be able to provide both a local and a global assessment of the tritium content within the top ≈1 μm of the inner wall surface. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2965-2968 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A novel system was developed, which allows one to switch the wavelength of a narrow-band excimer laser between two successive light pulses at a repetition rate of at least 250 Hz. This is realized by a periodically driven piezo actuator, which is attached to the diffraction grating of the narrow-band KrF excimer laser. The achieved position accuracy of the grating leads to a wavelength reproducibility of ±0.2 pm, which allows one to apply this system to laser spectroscopic investigations like LIF or LIPF of OH in flames. Using the fast wavelength switching system background reduced concentration and temperature fields in flames can be measured within one sequence. Some possible realized and planned applications like the measurement of gas temperature, the diagnostic of turbulent combustion processes, and the investigation of combustion processes under microgravity are discussed. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Despite the widespread use of corticosteroids on the mucous membranes of the nose, eye and bronchial tree, mucosal contact sensitivity has apparently been uncommon. However, since the introductinn of now corticosteroids such us tixocortol pivalate and budosonide, mucosal conlact sensitivity, particularly that affecting the nasal mucosa, has increasingly been reported. Contact allergy on other mucosal surfaces and in the bronchial tree is very rare. We report three women who had contact allergy to tixocortol pivalate or budesonide in nasal sprays, and one woman who had an allergic contact stomatitis from tixocortol pivalate in oral lozenges.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Mineralogy and petrology 64 (1998), S. 47-64 
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Bajo de la Alumbrera ist ein Beispiel für eine bedeutende Gold-Kupfer Lagerstätte in Kalium-reichen Magmatiten. Die Kupfer-Gold Lagerstätte Bajo de la Alumbrera gehört zum sogenannten Porphyry-Typ und befindet sich in der Catamarca Provinz im Nordwesten von Argentinien. Bajo de la Alumbrera zählt zu den zehn größten Kupferminen der Welt und ist einer der größten Goldproduzenten in Südamerika. Die Lagerstätte zeichnet sich aus durch eine klassische Zonierung der Alterationszonen, beginnend mit der zentral aufgeschlossenen `potassischen' Alterationszone (sekundärer Biotit-Magnetit-Orthoklas), die weiträumig von ‘propylitischer’ Alteration (sekundärer Epidot-Chlorit) umgeben wird. Beide Alterationstypen werden von einer spätgenetischen ‘phyllischen’ Alteration (sekundäre Tonminerale-Serizit-Pyrit) umgewandelt. Die Kupfer-Gold-Vererzung besteht überwiegend aus Kupferkies, der entweder feinverteilt in den Silikaten oder in Quarzadern innerhalb der potassischen Alterationszone vorkommt. Diese Zone beherbergt neben den höchsten Kupfergehalten auch die höchsten Gold-Gehalte von bis zu 2 ppm. Die Vererzung steht in direktem genetischen Zusammenhang mit subvulkanischen Dazit-Domen mit außergewöhnlich hohen Kalium-Gehalten, die die kalkalkalischen Andesite, Latite, Tuffbrekzien und Agglomerate der Ober-Miozänen Farallon Negro Formation intrudierten. Die Farallon Negro Formation stellt die erodierten Reste eines Stratovulkans mit schätzungsweise 16 Kilometern Durchmesser dar. Der Vulkanismus ereignete sich innerhalb eines ‘Pull-Apart’ Beckens, entlang eines großen Nordwest-streichenden Lineaments. Die dazitischen Muttergesteine der Kupfer-Gold-Vererzung haben porphyrische Texturen mit Phänokristallen bestehend aus Kalifeldspat, Plagioklas, Biotit, und, sehr selten, Amphibol in einer fein- bis mikrokristallinen Grundmasse. Die Häufigkeit von Mineralen wie Biotit und Apatit reflektiert die hohen Gehalte an volatilen Phasen in der Schmelze. Die mineralogische Zusammensetzung der Gesteine wurde von einer moderaten Klinopyroxen-Biotit-Apatit-Titanit Fraktionierung mitgeprägt. Einige der untersuchten Dazite wurden von einer schwachen bis moderaten Biotit-Magnetit-Orthoklas oder Karbonat-Serizit-Alteration überprägt. Die chemische Zusammensetzung der Dazite zeichnet sich aus durch hohe Gehalte an LILE (z. B. K20 bis zu 7.16 Gew%, Rb, Sr, und Ba bis zu 145 ppm, 445 ppm, und 610 ppm), moderate Gehalte an LREE (z.B. La 〈 73 ppm, und Ce 〈 140 ppm), und geringe Gehalte an HFSE (z.B. TiO2 〈 0.92 Gew%, Zr 〈 142 ppm, und Hf 〈 4.6 ppm), die typisch sind für Kalium-reiche Magmatite von kontinentalen Subduktionszonen. Die untersuchten Gesteine sind relativ fraktioniert und besitzen geringe mg# 〈 53. Ihre hohen Ba/Nb und Rb/Nb Verhältnisse sind typisch für Kalium-reiche Magmatite aus Subduktionszonen und unterscheiden sie eindeutig von Gesteinen aus within-plate settings. Die hohe Oxidationsstufe der Mutterschmelze reflektiert sich in den hohen Fe2O3/ (FeO + Fe2O3) Verhältnissen der untersuchten Gesteine von 0.49.
    Notes: Summary Bajo de la Alumbrera forms an example of a series of world class copper-gold deposits that are hosted by potassic igneous rocks. The Bajo de la Alumbrera porphyry copper-gold deposit is situated in the Catamarca Province of Northwest-Argentina and belongs to the ten largest copper mines in the world; it is also one of the largest gold producers in South America. The deposit is characterized by an alteration-zoning pattern with a central potassic core which grades outwards into a zone with propylitic alteration and an intermediate annular phyllic overprint. Porphyry copper-gold mineralization consists mainly of disseminated and/or vein-related chalcopyrite within the central potassic alteration zone which also hosts the highest gold grades (up to 2 ppm). Mineralization is genetically related to co-magmatic hypabyssal dacite domes with shoshonitic compositions which intruded the high-K calc-alkaline andesitic to latitic lava flows, breccia tuffs, and agglomerates of the Upper Miocene Farallon Negro Formation. The Farallon Negro Formation is interpreted as the remnants of a major stratovolcano some 16 km in diameter, with volcanism being controlled by sinistral pull-apart tectonics along a major NW-trending lineament. The dacitic rocks associated with the porphyry copper-gold mineralization have porphyritic textures with phenocrysts of alkali feldspar, plagioclase, biotite, and very rare amphibole in a fine-grained feldspathic groundmass. The abundance of hydrous minerals, such as biotite phenocrysts and apatite microphenocrysts, is consistent with the volatile-rich nature of the melts. The rocks underwent moderate degrees of clinopyroxene-biotite-âpatite-titanite fractionation. Several samples are overprinted by weak to moderate potassic or carbonate-sericite alteration. Geochemically, the dacites are characterized by high LILE (e.g. K20 up to 7.16 wt%, and Rb, Sr, and Ba up to 145 ppm, 445 ppm, and 610 ppm, respectively), moderate LREE (La 〈 73 ppm and Ce 〈 140 ppm), and low HFSE (TiO2 〈 0.92 wt%, Zr 〈 142 ppm, Hf 〈 4.6) which are typical for subduction-related potassic igneous rocks from a mature continental-arc setting. The rocks have evolved compositions with relatively low mg# 〈 53. Their high Ba/Nb and high Rb/Nb ratios (up to 87 and 31, respectively) clearly distinguish them from rocks derived from within-plate settings. The rocks from Bajo de la Alumbrera contain average ratios of Fe2O3/(FeO+Fe2O3) as high as 0.49 reflecting the oxidized nature of their parental melts.
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