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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sinusoids are found not only in the normal liver but also in certain liver tumours, including hepatoblastoma, the most common malignant liver tumour in childhood. In this study, sinusoids in 12 hepatoblastomas, of various subtypes, and in normal liver were investigated with UEA-1 and antibodies against von Willebrand's factor, CD31 and CD34 to detect differences of possible diagnostic significance. In the normal liver, staining of sinusoids was seen with all these markers, but it was focal and confined to a few sinusoids near the portal tracts. In hepatoblastoma, the endothelial markers reacted with the sinusoids to varying extents. UEA-1 and anti-CD34 usually stained the majority of these vessels, anti-CD34 staining greater numbers of sinusoids and with greater intensity. Immunostaining revealed that both number and spatial organization of sinusoids in hepatoblastoma are dependent on the subtype. In addition to staining of endothelium, one of the two small cell hepatoblastomas exhibited strong immunoreactivity of the tumour cells for CD34. These findings show that the marked difference in sinusoidal immunoreactivity for CD34 between normal liver and hepatoblastoma could be useful for discriminating between non-neoplastic liver tissue and highly differentiated fetal hepatoblastoma. Our findings also show that small cell hepatoblastoma, in addition to acute leukaemia, should be considered when immunoreactivity for CD34 is found in small round and blue cell tumours in childhood.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a recent study we described a population of small epithelial cells (SEC) in human hepatoblastoma that exhibit ultrastructural features of the oval cells of rodents. Both SEC and oval cells are immunoreactive for cytokeratin 7, a marker of biliary differentiation, and it was postulated that SEC, like oval cells, are closely related to hepatic stem cells. This study was undertaken to investigate whether SEC also exhibit immunolabelling for albumin, a marker of hepatocytic differentiation, and to determine whether other antigens typical of oval cells are detectable in hepatoblastoma.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and results:Hepatoblastomas of various subtypes were investigated by electron microscopy, and by immunohistochemistry with the monoclonal antibodies OV-1 and OV-6, which recognize antigens associated with oval cells. Double-labelling for cytokeratin 7 and albumin was carried out by immuno-electron microscopy. OV-1 stained scattered cells in seven of 12 tumours investigated and OV-6 in nine. On immunoelectron-microscopic investigation, SEC exhibited labelling for both cytokeratin 7 and albumin.〈section xml:id="abs1-3"〉〈title type="main"〉Conclusions:The results demonstrate that antigens associated with oval cells are found in certain cells in hepatoblastoma. SEC, like oval cells, co-express markers for hepatocytic and biliary differentiation. The findings further support the hypothesis that SEC are closely related to the putative bipotent hepatic stem cell, which, by definition, gives rise to both hepatocytes and biliary epithelial cells.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Unfallchirurg 101 (1998), S. 658-660 
    ISSN: 1433-044X
    Keywords: Key words Tuberculosis • BCG • Vaccine • ; Soft tissue infection • Therapy ; Schlüsselwörter Tuberkulose • BCG • Impfstoff • Weichteilinfektion • Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Komplikationen nach BCG-(Bacillus-Calmette-Guérin-)Impfung sind insgesamt selten und reichen vom lokalen Abszeß bis zu chronischen Ulzerationen. Hinsichtlich der Therapie der Komplikationen schwankt das therapeutische Vorgehen zwischen konservativer und operativer Behandlung. Im vorliegenden Fall war es durch eine akzidentelle Inokulation mit BCG-Impfstoff zu rezidivierenden Weichteilinfektionen gekommen. Der bisherige Krankheitsverlauf mit seinem therapeutischen Vorgehen wird diskutiert und ein Behandlungskonzept vorgeschlagen. Die radikale Exzision unter Schutz mit Antituberkulotika stellt aus heutiger Sicht die vielversprechenste Therapie dieses spezifischen Weichteilinfekts dar.
    Notes: Summary Complications after BCG vaccine (bacilli Calmette-Guérin) occur rarely. They can reach from a local acute abscess to chronic ulceration's. Therapeutically concepts of these complications range from conservative to operative treatment. In the following case history recurrent soft tissue infections occurred after accidental inoculation with BCG vaccine. The time course of these recurrent infections with its therapeutic options is discussed and a treatment strategy is suggested. Currently, radical excision combined with antituberculotic treatment seems to be the most promising therapy of this specific soft tissue infection.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-0385
    Keywords: Key words: Adrenocortical deficiency ; Adrenal gland tuberculosis ; Addison's disease ; Tuberculosis. ; Schlüsselwörter: Nebennierenrindenunterfunktion ; Nebennierentuberkulose ; Morbus Addison ; Tuberkulose.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die häufigste Ursache einer adrenocorticalen Insuffizienz (Morbus Addison) ist mit über 50 % die Autoimmunadrenalitis. Zu Anfang dieses Jahrhunderts war die Tuberkulose in 50–70 % der Fälle die Hauptursache. Die Tuberkulose spielt heute neben zahlreichen seltenen Ursachen mit etwa 10 % nur noch eine untergeordnete Rolle. Ein lediglich einseitiger Nebennierenbefall verläuft häufig asymptomatisch oder wie in der vorliegenden Kasuistik mit geringer bis mäßiger Symptomatik. Mit der Diagnose einer adrenocorticalen Insuffizienz ist die Frage nach der Ursache zunächst nicht geklärt. An der Beobachtung eines Patienten mit einer Nebennierentuberkulose werden die Probleme der Diagnosefindung und das therapeutische Vorgehen beschrieben und diskutiert.
    Notes: Summary. Adrenocortical insufficiency (Addison's disease) is a functional diagnosis. At the beginning of this century, tuberculosis was recognized as the main etiological cause (50–70 %). Today, however, tuberculosis represents only 10 % of the cases. Adrenocortical insufficiency is mainly caused by autoimmune adrenalitis (more than 50 %). Unilateral adrenocortical disease is usually asymptomatic or presents, as in the case described, with minor symptoms. This case report of adrenal tuberculosis illustrates the current challenges of diagnosis and therapy.
    Type of Medium: Electronic Resource
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