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  • 1
    Electronic Resource
    Electronic Resource
    Endoscopic ultrasound and intraductal ultrasound in the diagnosis of small pancreatic tumors (1998)
    Springer
    Abdominal imaging 23 (1998), S. 380-386 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Endoscopic ultrasound—Intraductal ultrasound—Pancreas—Small tumors—Characterization.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of this study was to assess the diagnostic value of endoscopic ultrasound (EUS) and intraductal ultrasound (IDUS) in the detection of small pancreatic tumors. Methods: EUS was performed in 166 patients with verified pancreatic disease. IDUS was performed in 46 patients. A microprobe was introduced into the main pancreatic duct through the papilla of Vater using the duodenoscope. Results: EUS was valuable in the detection of small pancreatic tumors. Ductal adenocarcinomas smaller than 1 cm were demonstrated as a hypoechoic mass with a central irregular hyperechoic area. EUS and IDUS were useful in the characterization of intraductal paillary tumors (ductectatic mucinous tumors). EUS demonstrated nodular excrescences, and IDUS depicted papillary proliferation of the duct epithelium, which are characteristic of carcinomas and adenomas but not of hyperplasia. Internal architecture of cystic neoplasms was clearly depicted by EUS, and differentiation of serous and mucinous tumors was readily achieved. A tumor as small as a 5-mm islet cell was demonstrated on EUS because islet cell tumors are very hypoechoic. Conclusion: EUS and IDUS are relatively noninvasive procedures and are useful in the detection of small tumors and differentiation of pancreatic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900365
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  • 2
    Electronic Resource
    Electronic Resource
    ErbB-2, a c-erbB-2-coded protein, is expressed in metastatic cells of adenocarcinoma of endometrium, cervix and ovaries (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten cases of gynecologic malignancies, including three endometrial, two ovarian and four cervical carcinomas, were studied for the expression of a 185 kDa protein (ErbB-2), coded by a proto-oncogene, c-erbB-2, in primary lesions as well as in metastatic lesions. Positive immunoreactivity was observed in all primary adenocarcinomas but not from squamous cell carcinomas. Many adenocarcinoma cells in distant metastatic sites or in tertiary lymph nodes were strongly stained for ErbB-2. These metastatic cells also showed an expression of proliferating cell nuclear antigen (PCNA). Detection of ErbB-2 mRNA by a reverse-transcription polymerase chain reaction showed that the transcription occurred exclusively in adenocarcinomas. To our knowledge, this is the first report demonstrating ErbB-2 expression in distant metastatic lesions of gynecologic cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05060411.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of ranitidine and lansoprazole in short-term low-dose triple therapy for Helicobacter pylori infection (1997)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To evaluate the efficacy and safety of two 1-week low-dose triple-therapy drug regimens involving antisecretory drugs for Helicobacter pylori infection, 99␣patients with H. pylori infection were treated with either lansoprazole or ranitidine used together with clarithromycin and metronidazole.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:The drug combination and administration periods in the proton pump inhibitor group were lansoprazole 30 mg o.m., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d., all given for 7 days (LCM group). The ranitidine group received ranitidine 150 mg b.d., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d. also for 7 days (RCM group). The presence or absence of H. pylori was determined from gastric biopsy specimens taken from both the antrum and the body, by smear, culture and tissue section (Giemsa stain). Cure was defined as failure to find evidence of H. pylori infection 4 weeks after antimicrobial therapy had ended.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The cure of H. pylori infection was 88% in the LCM group (44 of 50; 95% confidence interval (CI) = 79–97%) and 92% in the RCM group (45 of 49; 95% CI = 84–99%). The incidence of adverse events was 16% and 18% for the two groups, respectively.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:No significant differences in cure rate and safety profiles were noted between the two regimens, suggesting that moderate acid inhibition using an H2-blocker is sufficient to achieve optimal H. pylori eradication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00186.x
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  • 4
    Electronic Resource
    Electronic Resource
    Clonal expansion of γδ-T lymphocytes in an HTLV-I carrier, associated with chronic neutropenia and rheumatoid arthritis (1999)
    Springer
    Annals of hematology 78 (1999), S. 101-104 
    Details
    ISSN: 1432-0584
    Keywords: Key words LGL ; γδ-T lymphocyte ; Neutropenia ; HTLV-I ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report on an HTLV-I carrier showing clonal proliferation of γδ-T lymphocytes associated with chronic neutropenia and rheumatoid arthritis (RA). A 75-year-old Japanese woman had a 20-year history of RA and was found to have neutropenia and lymphocytosis by routine examinations. Her white cell count was 5,800/μl with 89% lymphocytes. The proliferating γδ-lymphocytes did not show the typical morphology of large granular lymphocytes (LGL) and were positive for CD3, TCRδ1, and HLA-DR but negative for CD4, CD8, and δTCS1. Clonally rearranged TCRγ-chain (Jγ) and TCRβ-chain (Cβ1) genes were detected by Southern blot analysis. Clonality of these proliferating γδ-T cells was confirmed by CDR3 size analysis for the TCRδ-chain. Anti-HTLV-I antibody was positive and the pX region of HTLV-I proviral DNA was detected by PCR analysis, but clonal integration of HTLV-I proviral DNA was not detected by Southern blotting analysis. The patient's clinical course has been stable, except for infrequent infectious episodes. The association of HTLV-I/II infection with T-LGL leukemia has been reported by several groups, although most cases exhibit TCRαβ+ type T cells. Analysis of the junctional sequence of TCR on T-LGL leukemia cells may clarify the role of HTLV-I/II infection in clonal T-cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050483
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  • 5
    Electronic Resource
    Electronic Resource
    A new adhesion process of glass to metal using the redox reaction (1996)
    Springer
    Journal of materials science 31 (1996), S. 4891-4898 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new adhesion process of glass to metal was developed based on the redox reaction without oxidation of the metal surface. PbO-based glasses were strongly adhered to nickel metal at low temperature (400–500 °C) in a low-oxygen atmosphere (〈 0.1 p.p.m.). The interfaces between glasses and metal were analysed by SEM-EDS. It was found that the reaction layer and lead metal were formed by the redox reaction at the interface. In the case of the adhesion of PbO-based glasses containing CuO to nickel, the main reduced product in the glass was Cu2O, and lead was not detected. The redox reaction was simulated by a thermodynamic equilibrium theory; the results agreed with the analysis by SEM-EDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355877
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  • 6
    Electronic Resource
    Electronic Resource
    Studies of the positive muon behavior in solid H2 and D2 (1997)
    Springer
    Hyperfine interactions 106 (1997), S. 39-44 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a pulsed muon beam, we have investigated the microscopic μ+ behavior in solid H2 and D2 down to 0.6 K by the μ+SR method. From the studies of μ+ spin relaxation phenomena in solid para‐ H2 and ortho‐ D2, we have found that μ+ forms three distinct microscopic states; H2μ+( D2μ+)(20\sim25\%), muonium (15\sim20\%) and μ+(\sim60\%). In H2μ+, the μ+ spin is depolarized in solid para‐ H2 and a local magnetic field Bloc=1\sim2 G is deduced from LF‐μ+SR measurements. The magnitude of Bloc is inconsistent with the magnetic dipolar field (\sim25 G) expected from the magnetic moments of two protons in the H2μ+ molecule and suggests that the H2μ+ molecule might be in the rotationally excited state. From LF‐μ+SR measurements, muonium and μ+ have been found to diffuse in solid o‐ D_2. The diffusion rate of muonium is two order of magnitude larger than that of μ+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012604900148
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