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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 128 (1999), S. 243-249 
    ISSN: 1432-1106
    Keywords: Key words Bimanual movements ; Mesial frontal cortex ; Supplementary motor area (SMA) ; Cingulate motor areas (CMA) ; Functional magnetic resonance imaging (fMRI)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In six healthy right-handed volunteers, we compared the cerebral activation pattern related to unimanual right- and left-hand movements and to bimanual in-phase and anti-phase movements using functional magnetic resonance imaging (fMRI). Internally paced unimanual finger-to-thumb opposition movements led to a strong contralateral activation of primary sensorimotor areas in all six subjects. Midline activity was lateralized to the left side during right-hand movements, but to both sides during left-hand movements. Activity patterns of bimanual in-phase movements resembled the combined activity patterns of the two unimanual conditions: right and left hemispheric activations of the primary sensorimotor cortices and predominantly left-sided medial frontal activity. In contrast, during anti-phase movements, we observed a clear increase in activity, in both right and left frontal midline areas and in right hemispheric, mainly dorsolateral premotor areas compared to in-phase movements. These results indicate that frontal midline activity is not specific for bimanual movements per se. It can already be involved during simple unimanual movements but becomes progressively more involved during more complex aspects of movement control.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Key words Parieto-premotor circuit ; Ventral premotor cortex ; Anterior intraparietal sulcus ; Object manipulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Functional magnetic resonance imaging (fMRI) was used to assess cerebral activation during manipulation of various complex meaningless objects as compared to manipulation of a single simple object (a sphere). Significant activation was found bilaterally in the ventral premotor cortex (Brodmann’s area 44), in the cortex lining the anterior part of the intraparietal sulcus (most probably corresponding to monkey anterior intraparietal area, AIP), in the superior parietal lobule and in the opercular parietal cortex including the secondary somatosensory area (SII). We suggest that the cortex lining the anterior part of the intraparietal sulcus and area 44 are functionally connected and mediate object manipulation in humans.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 17 (1996), S. 731-757 
    ISSN: 1572-9567
    Keywords: 1,1-difluoroethane ; correlation ; critical region ; HFC-152a ; R152a ; thermal conductivity ; transport properties ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Based on reliable. carefully selected data sets. equations for the thermal conductivity and the viscosity of the refrigerant R 112a are presented. They are valid at temperatures from 240 to 440 K, pressures up to 20 MPa. and densities up to 1050 kg · m−3. including the critical region.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 19 (1998), S. 1099-1109 
    ISSN: 1572-9567
    Keywords: photoacoustic detector ; thermal conductivity ; thermal diffusivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A resonant and a nonresonant photoacoustic detector were used to determine thermal diffusivities of gases. With a nonresonant detector thermal diffusivities can be determined in a wide range between 10−3 and 10−7 m2·s−1, whereas experiments with the resonant detector deliver thermal diffusivities in a range that is about a factor of 100 smaller. As refrigerants—HFCs, HCFCs, and hydrocarbons—are absorbents in the infrared at a wavelength of 3.39 μm, their thermal diffusivity can be determined without the addition of a trace gas, particularly at pressures below 0.01 MPa. At pressures above 0.1 MPa, the addition of ammonia as a trace gas is recommended. The absorption wavelength is then 1.531 μm. A simulation model for the nonresonant photoacoustic detector is presented for the design of a detector and for an extended error analysis.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 30 (1995), S. 467-472 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wird ein Modell vorgestellt, das den Einfluß des Kapillardrucks auf die Verdampfung eines dünnen Flüssigkeitsfilms berücksichtigt, der entlang einer senkrechten Platte herabrieselt. Die maßgebenden Gleichungen werden abgeleitet und numerisch mit einem Runge-Kutta-Verfahren veränderlicher Schrittweite integriert. Die numerischen Ergebnisse werden mit denen der Nusseltschen Filmtheorie verglichen. Dabei ergeben sich beträchtliche Abweichungen von dieser in den Bereichen, in denen der Flüssigkeitsfilm sehr dünn wird. Dies ist darauf zurückzuführen, daß die Nusseltsche Filmtheorie den Einfluß des Kapillardrucks auf die Filmkontur nicht berücksichtigt.
    Notes: Abstract A model is presented that considers the influence of capillary pressure on the evaporation of a liquid film on a vertical that plate. The governing equations are derived and numerically integrated with a step-variable Runge-Kutta method. The numerical results are compared with the analytical solution from Nusselt's film condensation theory. The deviation from the Nusselt film theory become very prominent when the liquid film becomes thin enough. This can be attributed to the fact that the Nusselt film theory does not consider the influence of capillary pressure on the shape of the liquid film.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 28 (1997), S. 10-17 
    ISSN: 1572-8838
    Keywords: hydrogen evolution ; mass transfer ; bubble growth ; flow channel ; two-phase flow ; dissolved hydrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The process of hydrogen evolution during alkaline electrolysis of aqueous solutions is governed by mass transfer, growth of hydrogen bubbles and removal of hydrogen from the cathode. Two mechanisms are decisive for hydrogen removal: (i) hydrogen dissolved in the solution is carried off from the cathode surface by diffusion and convection, and (ii) gas bubbles are transported by a two- phase flow. The paper describes experiments to determine the local concentration of dissolved hydrogen and the void fraction of hydrogen bubbles in aqueous solutions. Measurements were performed in a flow channel by varying the height of the cathode (40–400mm), the current density (up to 6250Am−2) and the mean velocity of the electrolyte (up to 0.95 m s−1). Two operating regimes of the electrolyser are found. At high current densities a back flow is observed leading to an increase in the electrolyte resistance. Traces of dissolved oxygen are detected at high current densities. At low current densities the two-phase flow is confined to a thin layer along the cathode surface, the concentration of dissolved hydrogen being small.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-5001
    Keywords: automated assignment ; distance geometry ; peptide deformylase ; protein structure ; structure refinement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The NMR structure of the peptide deformylase (PDF) (1–150) from Escherichia coli, which is an essential enzyme that removes the formyl group from nascent polypeptides and represents a potential target for drug discovery, was determined using 15N/13C doubly labeled protein. Nearly completely automated assignment routines were employed to assign three-dimensional triple resonance, 15N-resolved and 13C-resolved NOESY spectra using the program GARANT. This assignment strategy, demonstrated on a 17 kDa protein, is a significant advance in the automation of NMR data assignment and structure determination that will accelerate future work. A total of 2302 conformational constraints were collected as input for the distance geometry program DYANA. After restrained energy minimization with the program X-PLOR the 20 best conformers characterize a high quality structure with an average of 0.43 Å for the root-mean-square deviation calculated from the backbone atoms N, Cα and C′, and 0.81 Å for all heavy atoms of the individual conformers relative to the mean coordinates for residues 1 to 150. The globular fold of PDF contains two α-helices comprising residues 25–40, 125–138, six β-strands 57–60, 70–77, 85–88, 98–101, 105–111, 117–123 and one 310 helix comprising residues 49–51. The C-terminal helix contains the HEXXH motif positioning a zinc ligand in a similar fashion to other metalloproteases, with the third ligand being cysteine and the fourth presumably a water. The three-dimensional structure of PDF affords insight into the substrate recognition and specificity for N-formylated over N-acetylated substrates and is compared to other PDF structures.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0878
    Keywords: Key words LTBP ; Isoforms ; Splice variants ; Extracellular matrix ; TGFβ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Latent transforming growth factor-β (TGFβ) binding protein (LTBP), a component of the high-molecular-weight latent TGFβ complex, is found in various cell and tissue types. Originally described as a TGFβ-masking protein, recent detections of four isoforms and numerous splice variants provide new aspects of its putative functional role. Regulation and sequestration of TGFβ activity and structural remodeling of the extracellular matrix (ECM) seem to be the main tasks, but other possible functions might exist. The mechanism by which LTBP interacts with cell surface molecules or cellular receptors and ECM components remains unclear. Cellular, molecular and functional aspects will be discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A historical cohort study is carried out to investigate occupational hazards in the German rubber industry since 1991. We present and discuss the study objectives and study design features such as cohort definition, assessment of occupational exposure and selection of the reference population. Cohort enumeration, assessment of vital status and cause of death ascertainment are described. With approximately 2800 deaths throughout the observation period 1981 to 1991 it will be possible also to study the occupational etiology of rare diseases.
    Abstract: Résumé Én 1991 d'ébuta l'étude historique d'une cohorte analysant l'industrie allemande du caoutchouc et les maladies professionnelles provoquant le cancer. Les objectifs et les aspects de l'etude, de même que les critères de choix des entreprises, la définition de la cohorte, l'estimation de l'exposition professionnelle et les critères de choix de la population de référence sont décrits et commentés. Également sont présentés les processus de constitution de la cohorte, la définition de la constitution actuelle et dans certains cas les causes du décès de membres de la cohorte. L'observation de près de 2800 cas mortels sur une période allant de 1981 à 1991 permet une description — également dans le cas de mortalités rares — des risques professionnels encourus.
    Notes: Zusammenfassung 1991 wurde in der deutschen Kautschukindustrie mit der Durchführung einer historischen Kohortenstudie über das Berufskrebsrisiko begonnen. Zielsetzungen der Studie und Aspekte des Studiendesigns wie Auswahl der Unternehmen, Definition der Kohorte, Abschätzung der beruflichen Exposition und Wahl der Vergleichspopulation werden beschrieben und diskutiert. Die Verfahren zum Aufbau der Kohorte, zur Bestimmung des Vitalstatus und gegebenenfalls der Todesursache der Kohortenmitglieder werden dargestellt. Bei annähernd 2800 Todesfällen im Beobachtungszeitraum von 1981 bis 1991 wird es möglich sein, auch für seltene Todesursachen Aussagen zur beruflichen Gefährdung zu machen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Meteorology and atmospheric physics 70 (1999), S. 81-95 
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary  This paper is a contribution to experimental meteorology: A sea-breeze front was investigated by aircraft observations and thorough numerical analysis using an unprecedented number of runs crossing the same front within a timespan of . The 33 runs were flown in a situation of offshore geostrophic wind of 5 m/s in 1000 hPa and with the strategy of obtaining information on the four-dimensional field (t=time, x=cross-coastal coordinate, y=coast-parallel coordinate, z=height): 9 runs in x-direction (and reverse) at different heights to yield x,z-cross-sections of the observed meteorological quantities (specific humidity q, potential temperature Θ and the components u, v and w of the wind velocity), assuming a frozen structure in time; the next 7 runs again in x-direction but all at the same level and on the same track to yield x,t-diagrams of the same quantities in order to study the temporal changes compared to those with x and z; the next 10 runs as a zig-zagging flight track crossing the front but drifting in y-direction, all at the same height, in order to obtain the y-dependency; andfinally 7 runs for another x,z-cross-sectional analysis, which can be compared to that evaluated from the runs at the beginning of the mission. The paper describes the 4-dimensional dependencies in detail. Pure x-variations at constant z are expressed by VCM low-pass filtered space series (VCM=variance conserving multiresolution, according to Howell and Mahrt, 1994). The x,z-analyses are similar to those in Kraus et al. (1990) and Finkele et al. (1995) verifying these results. The comparison of the x,z-studies gained from the data at the beginning and at the end of the mission show how the sea-breeze frontal area changes its structure. The fluctuations (in time) revealed by the low-pass filtered x,t-runs (same track and same height) are smaller than the contour intervals chosen in the x,z-cross-sections. This shows, that the single runs, from which the x,z-cross-sections are constructed, reliably and significantly contribute to the interpolated structure. The paper also demonstrates the overall development of the front within the 31/2 h of continuous observation. The x,y-fields demonstrate that the y-dependency of the various quantities is generally one order of magnitude smaller than the x-dependency and that the assumption of negligible y-dependency holds in the first order of approximation for a fairly homogeneous coast. Convective disturbances of a horizontal scale of 1 to 4 km at the landward side of the front, embedded in the offshore flow and bouncing against the landward propagating sea-breeze front, considerably contribute to variations of the frontal propagation speed and of the frontal shape and also to changes of the parameters with the along-frontal coordinate y.
    Type of Medium: Electronic Resource
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