ISSN:
1432-1920
Keywords:
Key words Children
;
Chloral hydrate
;
Magnetic resonance imaging
;
Sedation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Orally administered chloral hydrate is the most widely used sedative in children undergoing MRI. We compared intermediate- and high-dose oral chloral hydrate in 97 consecutive children undergoing MRI in a prospective, controlled, double-blind, randomised clinical trial. There were 50 girls and 47 boys, mean weight (± SD) 14.7 ± 6.4 kg, and mean age 38 ± 31. The children were randomly allocated to receive chloral hydrate syrup either 70 mg/kg (group A, n = 50) or 100 mg/kg (group B, n = 47). These two groups were not significantly different in sex, weight, age, diagnosis or ambulatory medication. The mean initial dose (± SEM) was 64 ± 2 mg/kg for group A and 93 ± 2 mg/kg for group B. Because adequate sedation was not achieved, 14 patients in group A and 6 in group B required a second dose, giving a mean total dose of 70 ± 2 mg/kg for group A and 96 ± 2 mg/kg for group B. The percentage of successful examinations after the initial dose (A: 64 %, B: 87 %; p 〈 0.05) and the total dose (A: 92 %, B: 100 %; p = 0.14) was higher in group B. Significant differences were found for the time of onset of sedation (A: 28 ± 2 min, B: 21 ± 1 min; p 〈 0.05), but not for the time to spontaneous awakening after the completion of the examination. The rate of adverse reactions was similar (A: 20 %, B: 21 %; p = 1.00). We conclude that high-dose oral chloral hydrate improves the management of children undergoing MRI.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002340050180
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