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  • Electronic Resource  (3)
  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1985-1989  (1)
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  • Electronic Resource  (3)
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  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1985-1989  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Anti-Inflammatory Liver X Receptors and Related Molecules in Multiple Sclerosis Patients from Sardinia and Sweden (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Scandinavian journal of immunology 59 (2004), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The nuclear receptor heterodimers of liver X receptors (LXRs) are recently identified as key transcriptional regulators of genes involved in lipid homeostasis and inflammation. LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. Multiple sclerosis (MS), a demyelinating disease of the central nervous system of unknown cause, is characterized by recurrent inflammation involving macrophages and their inflammatory mediators. Sweden belongs to the countries with a high MS incidence. In Italy, incidence is lower, with an exception for Sardinia where the incidence is even higher than that in Sweden. Subjects from Sardinia are ethnically more homogeneous and differ from Swedes, also regarding genetic background and environment. We studied LXRs and their related molecules of blood mononuclear cells (MNCs) from female patients with untreated relapsing-remitting MS from Sassari, Sardinia and Stockholm, Sweden. Sex- and age-matched healthy controls (HCs) were from both areas. mRNA expression was evaluated by real-time PCR. LXR-α was lower (P 〈 0.05) in MS (mean ± SEM: 3.1 ± 0.2; n = 37) compared to HC (3.6 ± 0.1; n = 37). LXR-α was lower in MS from Stockholm (2.6 ± 0.2; n = 22) compared to corresponding HC (3.4 ± 0.1; n = 22; P 〈 0.01) and compared to MS (3.8 ± 0.2; n = 15; P 〈 0.001) and HC (4 ± 0.2; n = 15; P 〈 0.001) from Sardinia. MS patients from Stockholm, but not from Sassari, also expressed lower (P 〈 0.05) LXR-β (−4.1 ± 0.4) compared to corresponding HC (−2.9 ± 0.3). MS from Stockholm was associated with higher ABCA-1 (6.1 ± 0.4 versus 5.0 ± 0.3; P 〈 0.05) and higher estrogen receptor-β-Cx (2.4 ± 0.4 versus 0.8 ± 0.4; P 〈 0.01) compared to corresponding HC. The HC from Sassari had higher androgen receptor (2.9 ± 0.2) compared to MS from Sassari (1.4 ± 0.3; P 〈 0.01), MS (1.3 ± 0.4; P 〈 0.01) and HC from Stockholm (1.2 ± 0.3; P 〈 0.01). MS from Sassari had lower cyclooxygenase-1 compared to corresponding HC (5.1 ± 0.4 versus 6.6 ± 0.3; P 〈 0.01) and lower prostaglandin-E (−0.03 ± 0.5) compared to the HC (1.4 ± 0.5; P 〈 0.05) and MS (2.7 ± 0.4; P 〈 0.05) and HC from Stockholm (1.9 ± 0.4, P 〈 0.001). Our findings identify LXRs and their related molecules as being involved in MS from Stockholm but not from Sassari, while sex hormone receptors seem to be involved in MS in Sassari.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0300-9475.2004.01423d.x
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  • 2
    Electronic Resource
    Electronic Resource
    New neutron-rich isotopes of astatine and bismuth (1989)
    Springer
    The European physical journal 333 (1989), S. 131-135 
    Details
    ISSN: 1434-601X
    Keywords: 23.90.+w ; 27.90.+b
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Neutron-rich isotopes of astatine have been produced through spallation reactions with 600 MeV protons on a232Th target and identified by spectroscopic techniques combined with one-line mass separation at the ISOLDE facility. The half-lives of218At and219At have been remeasured to be 1.5(3) s and 57(4) s, respectively. Four new isotopes of astatine,220−223At, have been observed for the first time, and their half-lives were found to be 3.73(13) min, 2.3(2) min, 54(10) s, and 50(7) s, respectively. Another nuclide,216Bi, has been observed for the first time as the daughter product of the220At alpha decay, and its half-life has been measured to be 6.6(21) min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01565142
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  • 3
    Electronic Resource
    Electronic Resource
    Study of theβ +/EC decay of the neutron deficient nuclei76,78Sr and79Y (1992)
    Springer
    The European physical journal 341 (1992), S. 247-248 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The β+/EC decay of the neutron deficient nuclei76,78Sr and79Y was studied employing mass separated molecular beams of SrF+ and YF2 + from the ISOLDE mass separator. The halflives of76,78Sr and79Y were measured as t1/2=8.9(3)s, 159(8)s and 14.4(15)s, respectively, and decay schemes were established for76Sr and79Y. In the78Sr decay 10 new γ-ray transitions were identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298490
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