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  • 1
    Electronic Resource
    Electronic Resource
    A recessive resistance gene of alfalfa to alfalfa mosaic virus and impact of high ambient temperature on virus resistance (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 41 (1992), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Twenty plants of alfalfa cv. Beaver were screened for resistance to alfalfa mosaic virus (AIMV) severe strain A-515. ELISA screening on both inoculated and apical leaves at fixed temperature (20°C day, 16°C night) suggested the following three types of clonal response to AIMV infection: extremely resistant, AIMV not normally detected from either inoculated or apical leaves; resistant, AIMV detected from inoculated leaves only and did not spread systemically; susceptible, AIMV detected from both inoculated and apical leaves. When plants in the second category were maintained at high temperature (30°C), AIMV was detected from inoculated and apical leaves 6 and 12 days after inoculation, but was not detectable in the apical leaves thereafter. Plants in the first category remained extremely resistant at all temperatures tested. The results of comparative tests using progeny plants of extremely resistant, resistant and susceptible plants, and of their hybrids, suggested that the resistance to AIMV A-515 was controlled by a temperature-dependent recessive gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1992.tb02318.x
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  • 2
    Electronic Resource
    Electronic Resource
    The gene for Machado–Joseph disease maps to human chromosome 14q (1993)
    [s.l.] : Nature Publishing Group
    Nature genetics 4 (1993), S. 300-304 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Machado–Joseph disease (MJD) is an autosomal dominant, multisystem neurodegenerative disorder involving predominantly cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems. Although it was first reported in families of Portuguese–Azorean descent, MJD has also been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0793-300
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  • 3
    Electronic Resource
    Electronic Resource
    New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported.Aim : In this study, we evaluated the efficacy of H2-receptor antagonist (famotidine) and 5-HT4 receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second-step therapy.Methods : Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or 15 mg/day of mosapride citrate for 4 weeks and the efficacy was compared between the two groups based on a 10-point visual analogue scale. When symptoms were not relieved (score improvement 0–2 points), patients received amitriptyline (30 mg/day) or no medication for 4 weeks randomly. Patients who had depression in psychological test (SDS) were omitted.Results : As the first-step therapy, both famotidine and mosapride showed beneficial effects regardless of FD subtypes, age and gender. The efficacy of these two drugs in relieving FD symptoms was not significantly different. In patients who failed in the first-step therapy, amitriptyline showed beneficial effects.Conclusions : These findings might be clinically important in view of the efficient relief of symptoms in FD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02473.x
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  • 4
    Electronic Resource
    Electronic Resource
    Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 545-553 
    Details
    ISSN: 1432-0533
    Keywords: Corticobasal degeneration ; Ultrastructure ; Tau ; Glial inclusions ; Progressive supranuclear palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have studied brain tissues from three patients with corticobasal degeneration (CBD) histologically, ultrastructurally and immunohistochemically. Ballooned neurons in the cerebral cortex and severe degeneration of the substantia nigra were observed in them all and weakly basophilic neurofibrillary tangles (NFTs) were distributed widely in the basal ganglia and brain stem. Ultrastructural examination demonstrated that the NFTs comprised characteristic 15-nm-wide straight tubules, which showed positive immunohistochemical staining with an antibody against tau, but not ubiquitin. Tau-immunoreactive neuronal cell bodies without NFTs also were found in the cerebral cortex and subcortical nuclei, predominantly in the brain stem, and the greatest number of tau-positive glial inclusions occurred in the cerebral gray and white matter of the pre- and post-central gyri. These inclusions comprised tubular structures with diameters of about 15 nm and were localized in the oligodendroglial cellular cytoplasm and processes. These findings indicate that there is a close cytoskeletal pathological relationship between CBD and progressive supranuclear palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293314
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  • 5
    Electronic Resource
    Electronic Resource
    Lewy bodies in the lower sacral parasympathetic neurons of a patient with Parkinson's disease (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 558-559 
    Details
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Lewy body ; Dorsal group of nucleus intermediolateralis sacralis ; Parasympathetic neuron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lewy bodies were observed incidentally in the neurons of the dorsal group of nucleus intermediolateralis of the 3rd sacral segment of the spinal cord in a 74-year-old male with Parkinson's disease. The findings indicate the degeneration of the preganglionic parasympathetic neurons innervating the internal anal sphincter. The correlation between the findings and the mechanism of constipation in this disease are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294619
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  • 6
    Electronic Resource
    Electronic Resource
    Demyelination and remyelination in spinal cord lesions of human lymphotropic virus type I-associated myelopathy (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 78-83 
    Details
    ISSN: 1432-0533
    Keywords: HTLV-I-associated myelopathy ; Spinal cord lesion ; Electron microscopy ; Primary demyelination ; Remyelination by oligodendrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe postmortem findings in a patient with human T lymphotropic virus type I (HTLV-I)-as-sociated myelopathy (HAM). The patient developed the disease 8 years after blood transfusion and showed good response to corticosteroid treatment but died of cardiac failure. Histologically, chronic, mild meningoence-phalomyelitis was noted predominantly involving the bilateral lateral and anterior columns of the middle to lower thoracic segments. The spinal cord lesions showed obvious loss of myelinated nerve fibers and fibrillary gliosis with minimal inflammatory cell infiltration. Electron microscopy of the lesion revealed disintegration of the myelin sheaths, regular separation of the minor dense line of the myelin sheaths, and completely demyelinated axons. In addition, remyelinated fibers with thin central myelin sheaths and disproportionately large axons were seen frequently. These findings indicate that primary demyelination and remyelination by oligodendrocytes occur in the spinal cord lesions of HAM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662641
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  • 7
    Electronic Resource
    Electronic Resource
    Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 545-553 
    Details
    ISSN: 1432-0533
    Keywords: KeyWordsCorticobasal degeneration Ultrastructure ; Tau ; Glial inclusions Progressive supranuclear palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have studied brain tissues from three patients with corticobasal degeneration (CBD) histologically, ultrastructurally and immunohistochemically. Ballooned neurons in the cerebral cortex and severe degeneration of the substantia nigra were observed in them all and weakly basophilic neurofibrillary tangles (NFTs) were distributed widely in the basal ganglia and brain stem. Ultrastructural examination demonstrated that the NFTs comprised characteristic 15-nm-wide straight tubules, which showed positive immunohistochemical staining with an antibody against tau, but not ubiquitin. Tau-immunoreactive neuronal cell bodies without NFTs also were found in the cerebral cortex and subcortical nuclei, predominantly in the brain stem, and the greatest number of tau-positive glial inclusions occurred in the cerebral gray and white matter of the pre- and postcentral gyri. These inclusions comprised tubular structures with diameters of about 15 nm and were localized in the oligodendroglial cellular cytoplasm and processes. These findings indicate that there is a close cytoskeletal pathological relationship between CBD and progressive supranuclear palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293314
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Noise effects on spike propagation in the stochastic Hodgkin-Huxley models (1991)
    Springer
    Biological cybernetics 66 (1991), S. 19-25 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Effects of membrane current noise on spike propagation along a nerve fiber are studied. Additive current noise and channel noise are considered by using stochastic versions of the Hodgkin-Huxley model. The results of computer simulation show that the membrane noise causes considerable variation of the propagation time of a spike (thus changes in interspike intervals) for a small unmyelinated fiber of radius 0.1∼1 μm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196449
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  • 9
    Electronic Resource
    Electronic Resource
    Durable, hydrophilic surface modification of polypropylene films by plasma graft polymerization of glycidyl methacrylate (1991)
    Springer
    Polymer bulletin 26 (1991), S. 283-289 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary The plasma graft polymerization of glycidyl methacrylate (GMA) was investigated to obtain hydrophilic surface. The combination of the argon plasma and GMA vapor exposures leaded to graft polymerization of GMA at the surface of polypropylene films. This graft polymerization was initiated by the argon plasma exposure for 2 min, and was accomplished with the GMA vapor exposure for 2 min. The GMA graft polymerization made polypropyrene surface hydrophilic. The surface energy was 55.8 mJ/m2. The hydrophilicity introduced by the GMA graft polymerization remained for at least 3 weeks. The graft polymerization of hydrophilic monomers was a good means of hydrophilic surface modification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587971
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